INT6934

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Context Info
Confidence 0.48
First Reported 1983
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 51
Total Number 53
Disease Relevance 7.72
Pain Relevance 25.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRD1) cytoplasm (OPRD1) signal transducer activity (OPRD1)
Anatomy Link Frequency
brain 3
NG108-15 2
cerebral cortex 1
superior 1
VTA 1
OPRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 125 100.00 Very High Very High Very High
Opioid 68 100.00 Very High Very High Very High
Delta opioid receptors 22 100.00 Very High Very High Very High
Immobilon 10 100.00 Very High Very High Very High
Endogenous opioid 9 100.00 Very High Very High Very High
antagonist 37 99.92 Very High Very High Very High
Morphine 16 99.84 Very High Very High Very High
Pain 11 99.68 Very High Very High Very High
Enkephalin 57 99.62 Very High Very High Very High
cerebral cortex 3 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Opiate Addiction 27 99.84 Very High Very High Very High
Neuroblastoma 9 99.84 Very High Very High Very High
Eating Disorder 12 99.76 Very High Very High Very High
Pain 8 99.68 Very High Very High Very High
Drug Dependence 4 99.50 Very High Very High Very High
Glioma 2 99.20 Very High Very High Very High
Shock 4 99.04 Very High Very High Very High
Respiratory Failure 4 98.60 Very High Very High Very High
INFLAMMATION 6 98.56 Very High Very High Very High
Stress 4 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on the genotype and allele frequencies of the genomic control loci, there was no evidence for stratification bias capable of masking an association of OPRD1 to heroin dependence in this large and homogenous Chinese sample.
OPRD1 Binding (association) of associated with addiction and opiate addiction
1) Confidence 0.48 Published 2002 Journal Am. J. Med. Genet. Section Abstract Doc Link 12116270 Disease Relevance 0.58 Pain Relevance 0.48
Therefore, these data do not support an association between the OPRD1 gene and heroin dependence in the Chinese population.
OPRD1 gene Binding (association) of associated with addiction and opiate addiction
2) Confidence 0.48 Published 2002 Journal Am. J. Med. Genet. Section Abstract Doc Link 12116270 Disease Relevance 0.60 Pain Relevance 0.42
Oligomerization of the human delta-opioid receptor and its regulation by ligand occupancy were explored following expression in HEK293 cells using each of co-immunoprecipitation of differentially epitope-tagged forms of the receptor, bioluminescence resonance energy transfer and time-resolved fluorescence resonance energy transfer.
delta-opioid receptor Binding (Oligomerization) of associated with opioid receptor
3) Confidence 0.47 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11278447 Disease Relevance 0 Pain Relevance 0.21
Our observations demonstrate that gender, ethnicity and temperament contribute to individual variation in thermal and cold pain sensitivity by interactions with TRPV1 and OPRD1 single nucleotide polymorphisms.
OPRD1 Binding (interactions) of associated with pain
4) Confidence 0.47 Published 2004 Journal Pain Section Abstract Doc Link 15157710 Disease Relevance 0.38 Pain Relevance 0.60
A constrained three-compartment kinetic model was demonstrated to be superior to other quantification models for the description of MeNTI kinetics and quantification of delta receptor binding in the human brain with 11C-labeled MeNTI.
delta receptor Binding (binding) of in superior
5) Confidence 0.42 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10478647 Disease Relevance 0 Pain Relevance 0.29
This review summarizes a decade of research from many laboratories that defined which residues and substituents in the deltorphins interact with the delta-receptor and characterized pharmacological and physiological activities in vitro and in vivo.
delta-receptor Binding (interact) of
6) Confidence 0.41 Published 1999 Journal Prog. Neurobiol. Section Abstract Doc Link 10080383 Disease Relevance 0 Pain Relevance 0.15
Novel "restoration of function" mutagenesis strategy to identify amino acids of the delta-opioid receptor involved in ligand binding.
delta-opioid receptor Binding (binding) of associated with analgesic and opioid receptor
7) Confidence 0.39 Published 1997 Journal J. Biol. Chem. Section Title Doc Link 9083060 Disease Relevance 0 Pain Relevance 0.36
To test the hypothesis that OPRD1 or a closely linked gene is associated with heroin dependence, we used 5' nuclease assays to genotype both OPRD1 SNPs in 450 Chinese heroin dependent patients and 304 unaffected controls from the same population.
OPRD1 Binding (associated) of associated with addiction and opiate addiction
8) Confidence 0.37 Published 2002 Journal Am. J. Med. Genet. Section Abstract Doc Link 12116270 Disease Relevance 0.59 Pain Relevance 0.48
The phenol hydroxyl group of SL-3111 turned out to be essential to maintain high affinity for the delta-opioid receptor, which also was observed in the case of the delta-opioid-selective peptide ligand DPDPE.
delta-opioid receptor Binding (affinity) of associated with opioid receptor and opioid
9) Confidence 0.37 Published 1998 Journal J. Med. Chem. Section Abstract Doc Link 9822547 Disease Relevance 0 Pain Relevance 0.62
A hypothesis describing the conformational events accompanying selective deltorphin II binding to the delta-opioid receptor is presented.
delta-opioid receptor Binding (binding) of associated with opioid receptor
10) Confidence 0.36 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14999000 Disease Relevance 0 Pain Relevance 0.11
These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN).
OPRD1 Binding (association) of associated with opioid, serotonin and eating disorder
11) Confidence 0.35 Published 2007 Journal Biol. Psychiatry Section Abstract Doc Link 16806108 Disease Relevance 0.45 Pain Relevance 0.15
RESULTS: We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1.
OPRD1 Binding (associated) of
12) Confidence 0.35 Published 2007 Journal Biol. Psychiatry Section Body Doc Link 16806108 Disease Relevance 0.09 Pain Relevance 0
Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa.
OPRD1 Binding (association) of associated with eating disorder
13) Confidence 0.35 Published 2007 Journal Biol. Psychiatry Section Title Doc Link 16806108 Disease Relevance 0.38 Pain Relevance 0.13
The hasubanan alkaloids showed affinity for the human delta-opioid receptor with IC(50) values ranging from 0.7 to 46 microM.
delta-opioid receptor Binding (affinity) of associated with opioid receptor
14) Confidence 0.33 Published 2010 Journal J. Nat. Prod. Section Abstract Doc Link 20426456 Disease Relevance 0 Pain Relevance 0.30
Morphine, which binds mu- as well as delta-opioid receptors, down-regulated both receptor subtypes.
delta-opioid Binding (binds) of associated with delta opioid receptors and morphine
15) Confidence 0.32 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8394999 Disease Relevance 0.15 Pain Relevance 1.03
Desensitization of the delta-opioid receptor correlates with its phosphorylation in SK-N-BE cells: involvement of a G protein-coupled receptor kinase.
delta-opioid receptor Binding (Desensitization) of associated with opioid receptor and immobilon
16) Confidence 0.32 Published 1998 Journal J. Neurochem. Section Title Doc Link 9572300 Disease Relevance 0 Pain Relevance 0.47
The level of delta-receptor binding increases markedly during the third postnatal week in all brain areas examined.
delta-receptor Spec (examined) Binding (binding) of in brain
17) Confidence 0.31 Published 1987 Journal Brain Res. Section Abstract Doc Link 2830947 Disease Relevance 0 Pain Relevance 0.29
Saturation bioluminescence resonance energy transfer studies indicated the alpha(1A-1)-adrenoceptor homodimer interactions to be high affinity and some 75 times greater than interactions between the alpha(1A-1)-adrenoceptor and the delta opioid peptide receptor.
delta opioid peptide receptor Binding (interactions) of associated with opioid
18) Confidence 0.31 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15266013 Disease Relevance 0 Pain Relevance 0.14
Taken together, pharmacological and hydrodynamic studies suggest that the opioid receptors present in the SK-N-BE cell membranes could belong to two delta-opioid receptor subtypes interacting allosterically.
delta-opioid receptor Binding (interacting) of associated with opioid receptor
19) Confidence 0.30 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8113811 Disease Relevance 0.23 Pain Relevance 0.63
To assess the changes in conformation accompanying binding of the endogenous opioid peptide deltorphin II to the delta-opioid receptor at both the receptor and ligand levels as well as to determine points of contact between the two, an in-depth spectroscopic study that addressed these points was initiated.
delta-opioid receptor Spec (determine) Binding (binding) of associated with endogenous opioid and opioid receptor
20) Confidence 0.28 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14999000 Disease Relevance 0 Pain Relevance 0.32

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