INT69369

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Context Info
Confidence 0.33
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.07
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tdo2)
Anatomy Link Frequency
nerve 1
granule cells 1
Tdo2 (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 3 98.68 Very High Very High Very High
Nerve growth factor 2 97.24 Very High Very High Very High
Hippocampus 76 96.24 Very High Very High Very High
anesthesia 2 75.00 Quite High
midbrain 8 70.96 Quite High
Central nervous system 6 58.56 Quite High
sSRI 2 35.20 Quite Low
fluoxetine 12 33.00 Quite Low
Glutamate 2 32.48 Quite Low
antidepressant 10 32.00 Quite Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 58 68.96 Quite High
Anxiety Disorder 58 50.00 Quite Low
Diphtheria 2 12.48 Low Low
Depression 18 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Schizophrenia 10 5.00 Very Low Very Low Very Low
Stress 8 5.00 Very Low Very Low Very Low
Autism 6 5.00 Very Low Very Low Very Low
Mental Disorders 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Assays for hepatic TDO activity were carried out using L-Trp as substrate as previously described [48], with activity expressed as ?
TDO Binding (activity) of
1) Confidence 0.33 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0 Pain Relevance 0
This finding suggests the presence of compensatory mechanisms to maintain Kyn and KYNA levels in Tdo-/- mice; and given that IDO mediates the same metabolic processes as TDO in various tissues, it is the most likely candidate.
Tdo Binding (maintain) of
2) Confidence 0.33 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0 Pain Relevance 0.07
This consumption is further supported by the notion that the kynurenine, downstream metabolite of TDO, is capable of inducing expression of the neuronal survival factor, nerve growth factor [29-31] and the kynurenic acid is capable of mediating suppression of excessive NMDA and ?
TDO Binding (metabolite) of in nerve associated with nerve growth factor
3) Confidence 0.32 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0.07 Pain Relevance 0.16
To evaluate the pattern of TDO expression within postmitotic granule cells, we performed immunofluorescence double-labeling for calretinin and calbindin with TDO.
TDO Binding (calbindin) of in granule cells
4) Confidence 0.32 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0
Isoflurane produced a 50% increase of beta-glucuronidase activity and a 35% diminution of tryptophan pyrrolase. 5.
pyrrolase Binding (diminution) of associated with isoflurane
5) Confidence 0.06 Published 1997 Journal Gen. Pharmacol. Section Abstract Doc Link 9147027 Disease Relevance 0 Pain Relevance 0.28

General Comments

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