INT69378

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Context Info
Confidence 0.13
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.16
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) peptidase activity (MBTPS1) aging (FOS)
Golgi apparatus (MBTPS1) endoplasmic reticulum (MBTPS1) nucleolus (FOS)
Anatomy Link Frequency
glial cells 2
FOS (Homo sapiens)
MBTPS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 2 65.68 Quite High
Opioid 2 63.92 Quite High
Enkephalin 4 63.48 Quite High
Disease Link Frequency Relevance Heat
Neurological Disease 2 56.36 Quite High
Htlv Types I And Ii 2 55.08 Quite High
Leukemia 2 52.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The comparative electrophoretic mobility shift and 'supershift' analysis using specific antibodies indicated the enhanced presence of c-Fos and c-Jun proteins in the DNA: protein complex formed at the AP-1 site.
Positive_regulation (enhanced) of c-Fos Binding (complex) of AP-1 site
1) Confidence 0.13 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9147818 Disease Relevance 0.16 Pain Relevance 0.16
The tax1 induced c-Fos protein levels and the concurrently increased association of c-Fos/c-Jun transcription factors at the AP-1 site imply a strong functional significance in the activation of proenkephalin gene expression in tax1 expressing glial cells.
Positive_regulation (increased) of c-Fos Binding (association) of AP-1 site in glial cells
2) Confidence 0.08 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9147818 Disease Relevance 0 Pain Relevance 0.14

General Comments

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