INT69392

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Context Info
Confidence 0.44
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.43
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CNTN2) plasma membrane (CNTN2)
Anatomy Link Frequency
glial cells 2
T lymphocyte 2
CNTN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 20 97.86 Very High Very High Very High
rheumatoid arthritis 34 97.80 Very High Very High Very High
Arthritis 26 68.88 Quite High
Sicca syndrome 2 65.04 Quite High
Inflammation 46 60.36 Quite High
Osteoarthritis 90 51.88 Quite High
Neurotransmitter 3 50.92 Quite High
Opioid 1 49.16 Quite Low
Enkephalin 3 48.72 Quite Low
imagery 2 20.64 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 34 97.80 Very High Very High Very High
Synovitis 6 96.64 Very High Very High Very High
Infection 39 85.12 High High
Arthropathy 20 84.64 Quite High
Hypercalcemia 2 78.96 Quite High
Malignant Neoplastic Disease 4 76.88 Quite High
Htlv Types I And Ii 25 75.76 Quite High
Arthritis 34 68.88 Quite High
Disease 12 68.84 Quite High
Uveitis 3 65.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The tax1 induced c-Fos protein levels and the concurrently increased association of c-Fos/c-Jun transcription factors at the AP-1 site imply a strong functional significance in the activation of proenkephalin gene expression in tax1 expressing glial cells.
Positive_regulation (activation) of Gene_expression (expressing) of tax1 in glial cells
1) Confidence 0.44 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9147818 Disease Relevance 0 Pain Relevance 0.03
In addition, mice overexpressing Tax, the protein encoded by the HTLV-I pX region, develop RA-like chronic and systemic synovitis [8].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Tax associated with synovitis and rheumatoid arthritis
2) Confidence 0.33 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 1.69 Pain Relevance 0.31
The non-HTLV transformed T lymphocyte cells (CEM and H9) and kidney epithelial cells (293T) ), the HTLV1 transformed cells (C81 and HUT102), the H9 cells stably transfected with Tax1 of HTLV1 (H9-Tax1) and the 293T cells transfected with HTLV3 (293T-HTLV3) and expressing Tax3 (293T-Tax3) were maintained in RPMI 1640 medium containing fetal bovine serum, L-glutamine (2 mM), penicillin (100 units/ml) and streptomycin (100 µg/ml).
Positive_regulation (transfected) of Gene_expression (transfected) of Tax1 in T lymphocyte
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.07 Pain Relevance 0
Although Tax expression was not correlated with cytokine concentration in SF, probably owing to the time discrepancy between SF aspiration and tissue preparation, Tax expression in synoviocytes might be responsible, at least in part, for the increased concentrations of PTHrP, sIL-2R and IL-6 in SF of carrier patients.
Spec (might) Positive_regulation (responsible) of Gene_expression (expression) of Tax associated with cytokine
4) Confidence 0.22 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 0.67 Pain Relevance 0.24

General Comments

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