INT69395

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Context Info
Confidence 0.68
First Reported 1997
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 28
Total Number 41
Disease Relevance 13.29
Pain Relevance 4.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CNTN2) plasma membrane (CNTN2)
Anatomy Link Frequency
glial cells 6
T-lymphocytes 5
hippocampus 2
B lymphocytes 1
epithelial cells 1
CNTN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 14 100.00 Very High Very High Very High
cytokine 175 99.00 Very High Very High Very High
rheumatoid arthritis 119 97.80 Very High Very High Very High
potassium channel 166 96.28 Very High Very High Very High
Dopamine 96 95.24 Very High Very High Very High
Osteoarthritis 315 94.40 High High
adenocard 60 92.48 High High
Inflammation 195 90.12 High High
iatrogenic 26 85.08 High High
Neurotransmitter 30 84.32 Quite High
Disease Link Frequency Relevance Heat
Contagious Ecthyma 65 100.00 Very High Very High Very High
Glioma 12 99.10 Very High Very High Very High
Rheumatoid Arthritis 119 97.80 Very High Very High Very High
Synovitis 21 96.64 Very High Very High Very High
Death 148 94.52 High High
Frailty 322 94.40 High High
Infection 544 93.76 High High
Repression 52 93.52 High High
Leukemia 254 93.40 High High
Lymphatic System Cancer 104 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The tax1 induced c-Fos protein levels and the concurrently increased association of c-Fos/c-Jun transcription factors at the AP-1 site imply a strong functional significance in the activation of proenkephalin gene expression in tax1 expressing glial cells.
Gene_expression (expressing) of tax1 in glial cells
1) Confidence 0.68 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9147818 Disease Relevance 0 Pain Relevance 0
The HTLV-1 tax1 expressing stable glial cell lines produced functional tax1 protein that increased the expression of endogenous proenkephalin gene.
Gene_expression (expressing) of tax1 in glial cell
2) Confidence 0.68 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9147818 Disease Relevance 0.19 Pain Relevance 0.19
The HTLV-1 tax1 expressing stable glial cell lines produced functional tax1 protein that increased the expression of endogenous proenkephalin gene.
Gene_expression (produced) of tax1 in glial cell
3) Confidence 0.68 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9147818 Disease Relevance 0.19 Pain Relevance 0.18
The c-Fos protein expression significantly increased in the tax1 expressing glial cells.
Gene_expression (expressing) of tax1 in glial cells
4) Confidence 0.68 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9147818 Disease Relevance 0 Pain Relevance 0.14
We investigated the cellular transcription factors in tax1 expressing glial cells that associate with the proenkephalin promoter and herein demonstrate the enhanced interaction and involvement of c-Fos/c-Jun proteins in the complexes formed at the AP-1 site.
Gene_expression (expressing) of tax1 in glial cells
5) Confidence 0.68 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9147818 Disease Relevance 0.22 Pain Relevance 0.21
The tax1 induced c-Fos protein levels and the concurrently increased association of c-Fos/c-Jun transcription factors at the AP-1 site imply a strong functional significance in the activation of proenkephalin gene expression in tax1 expressing glial cells.
Gene_expression (expressing) of tax1 in glial cells
6) Confidence 0.59 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9147818 Disease Relevance 0 Pain Relevance 0
To determine if our observations were cell line specific and to explore the role of Tax1 expression, the LAESI experiments were extended to other cell lines, e.g., non-HTLV1 transformed T lymphocytes (H9), their Tax1-transfected counterparts (H9-Tax1) and HTLV1-transformed cells (HUT102 cells).
Gene_expression (expression) of Tax1 in T lymphocytes
7) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.03
Their biological importance and relevance to transformation and/or Tax expression is discussed below.
Gene_expression (expression) of Tax
8) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.13
We focus on changes related to HTLV induced transformation or Tax expression that alter the metabolic profiles in different cell lines.
Gene_expression (expression) of Tax
9) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.08 Pain Relevance 0.06
Although Tax expression was not correlated with cytokine concentration in SF, probably owing to the time discrepancy between SF aspiration and tissue preparation, Tax expression in synoviocytes might be responsible, at least in part, for the increased concentrations of PTHrP, sIL-2R and IL-6 in SF of carrier patients.
Gene_expression (expression) of Tax associated with cytokine
10) Confidence 0.36 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 0.60 Pain Relevance 0.22
In our study we used immunohistochemistry to examine the expression of the Tax protein and showed the expression of Tax in synoviocytes in all samples examined.
Spec (examine) Gene_expression (expression) of Tax
11) Confidence 0.36 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 0.65 Pain Relevance 0.24
We also studied the histopathological features of synovia of eight HTLV-I carrier patients, and determined the expression of Tax protein by immunohistochemistry.


Spec (determined) Gene_expression (expression) of Tax
12) Confidence 0.36 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 1.62 Pain Relevance 0.52
In addition, mice overexpressing Tax, the protein encoded by the HTLV-I pX region, develop RA-like chronic and systemic synovitis [8].
Gene_expression (overexpressing) of Tax associated with synovitis and rheumatoid arthritis
13) Confidence 0.36 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 1.69 Pain Relevance 0.31
Although Tax expression was not correlated with cytokine concentration in SF, probably owing to the time discrepancy between SF aspiration and tissue preparation, Tax expression in synoviocytes might be responsible, at least in part, for the increased concentrations of PTHrP, sIL-2R and IL-6 in SF of carrier patients.
Gene_expression (expression) of Tax associated with cytokine
14) Confidence 0.36 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 0.65 Pain Relevance 0.24
We used the LAESI technique to identify metabolic changes in HTLV1 and Tax1 transformed T lymphocytes and in HTLV3 and Tax3 transfected kidney epithelial cells.
Gene_expression (transformed) of Tax1 in epithelial cells
15) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0
These results suggest that the metabolic changes observed in the HTLV1 transformed cells can, in part, be attributed to Tax1 expression.

293T vs. 293T-HTLV3 and 293T-Tax3 cells

Gene_expression (293T) of Tax1
16) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.05
These results suggest that the metabolic changes observed in the HTLV1 transformed cells can, in part, be attributed to Tax1 expression.

293T vs. 293T-HTLV3 and 293T-Tax3 cells

Gene_expression (expression.) of Tax1
17) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.05
In our study we used immunohistochemistry to examine the expression of the Tax protein and showed the expression of Tax in synoviocytes in all samples examined.
Gene_expression (expression) of Tax
18) Confidence 0.32 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 0.60 Pain Relevance 0.22
In this study we detected the changes in various metabolite and lipid levels upon HTLV transformation and Tax expression in T lymphocytes and kidney epithelial cells.
Gene_expression (expression) of Tax in T lymphocytes
19) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.07
For comparison purposes, we performed similar experiments on cells transfected with either the HTLV3 molecular clone or Tax3 and compared these metabolic profiles with the results for HTLV1 transformed and Tax1 expressing cells.


Gene_expression (expressing) of Tax1
20) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.08 Pain Relevance 0

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