INT69396

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Context Info
Confidence 0.65
First Reported 1997
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 72
Total Number 76
Disease Relevance 38.16
Pain Relevance 4.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
MCF-7 5
microglial cells 4
muscle 3
peripheral nerve 3
skeletal muscle 2
H2-K1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 304 99.30 Very High Very High Very High
Inflammation 461 98.48 Very High Very High Very High
Peripheral nerve injury 25 98.48 Very High Very High Very High
cytokine 122 97.32 Very High Very High Very High
Sciatic nerve 275 92.72 High High
spinal inflammation 1 92.40 High High
gABA 50 89.60 High High
anesthesia 72 85.28 High High
cINOD 5 84.36 Quite High
Inflammatory stimuli 51 83.64 Quite High
Disease Link Frequency Relevance Heat
Cancer 1351 99.84 Very High Very High Very High
Breast Cancer 460 99.80 Very High Very High Very High
Adhesions 15 99.72 Very High Very High Very High
Targeted Disruption 391 99.64 Very High Very High Very High
Stress 256 99.34 Very High Very High Very High
Infection 240 99.28 Very High Very High Very High
Rheumatic Diseases 3 99.16 Very High Very High Very High
Injury 209 99.00 Very High Very High Very High
Immunotherapy Of Cancer 64 98.88 Very High Very High Very High
INFLAMMATION 449 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In competition assays 50 ng unlabeled H2K or AP-1 oligonucleotides were used.


Gene_expression (oligonucleotides) of H2K
1) Confidence 0.65 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.19 Pain Relevance 0
Interestingly, the elevated expression of MHC I in wild type mice co-localized with Iba-1 labeling (Figure 2C).
Gene_expression (expression) of MHC I
2) Confidence 0.29 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.23 Pain Relevance 0
To determine whether astrocytes could express classical MHC I, double labeling was performed using antibodies against GFAP and MHC I (Figure 4).
Gene_expression (express) of MHC I in astrocytes
3) Confidence 0.29 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.23 Pain Relevance 0
In order to analyze expression of classical MHC I in ventral horn, Iba-1 and MHC I double labeling was performed.
Spec (analyze) Gene_expression (expression) of MHC I in horn
4) Confidence 0.29 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.24 Pain Relevance 0
The present results are consistent with this hypothesis, since iNOS-/- mice displayed significantly reduced expression of MHC I one and two weeks after lesioning.
Gene_expression (expression) of MHC I
5) Confidence 0.29 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.30 Pain Relevance 0.15
Following peripheral lesioning, production of NO influences the expression of MHC I in the CNS microenviroment, affecting the synaptic plasticity process.
Gene_expression (expression) of MHC I
6) Confidence 0.29 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.29 Pain Relevance 0.17
In this case, the normal activity of iNOS could lead to astrogliosis and the expression of MHC I.
Gene_expression (expression) of MHC I
7) Confidence 0.29 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.30 Pain Relevance 0
Recently, the expression of the class I major histocompatibility complex (MHC I) was related to synaptic plasticity and to astrogliosis after peripheral nerve transection [22-26].
Gene_expression (expression) of MHC I in peripheral nerve
8) Confidence 0.29 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.37 Pain Relevance 0.18
This is relevant to the regenerative outcome because C57BL6/J mice, which express reduced amounts of classical MHC I compared to A/J animals, show decreased axonal growth in regenerating peripheral nerve and a delayed return of peripheral nerve function [26].
Gene_expression (express) of MHC I in peripheral nerve
9) Confidence 0.29 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.37 Pain Relevance 0.12
Balb/c (H-2K[d]) MHC-I expression remained low and was 1.09±0.40 at day 40 after transplantation.
Gene_expression (expression) of MHC-I
10) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.28 Pain Relevance 0
On day 40 after transplantation of allogeneic NA-BMCs the MHC-I expression of donor Balb/c (H-2K[d]) remained low (3.1±2.6%) while the recipient MHC-I molecules of C57Bl/6(H-2D[b]) were highly expressed (94.3±5.4%) (Figure 4A).
Gene_expression (expression) of MHC-I
11) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.21 Pain Relevance 0
Donor Balb/c (H-2K[d]) MHC-I expression remained low after transplantation until the end of the experiment (Table 2).
Gene_expression (expression) of MHC-I
12) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.27 Pain Relevance 0
On day 40 after transplantation of allogeneic NA-BMCs the MHC-I expression of donor Balb/c (H-2K[d]) remained low (3.1±2.6%) while the recipient MHC-I molecules of C57Bl/6(H-2D[b]) were highly expressed (94.3±5.4%) (Figure 4A).
Gene_expression (expressed) of MHC-I
13) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.27 Pain Relevance 0
The results obtained in the present study reinforce the importance of the MHC I expression by neurons and reactive glia after peripheral injury, and indicate that microglial cells respond to most glial expression of such molecules.
Gene_expression (expression) of MHC I in microglial cells associated with injury
14) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.31 Pain Relevance 0
Lesioning did not result in any significant increase of MHC I expression on the unlesioned side (not shown).
Gene_expression (expression) of MHC I
15) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.26 Pain Relevance 0
Also, MHC I expression in iNOS knockout mice was not increased at either 7 or 21 days after axotomy (Figures 2F and 2H), indicating that the absence of MHC I expression in iNOS-/- mice does not represent a delayed response but rather a collateral effect of the gene knockout.
Gene_expression (expression) of MHC I associated with targeted disruption
16) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.25 Pain Relevance 0
This difference in MHC I expression by wild type microglial cells at different time points after lesioning is shown in Figure 2J (C57BL6/J one week, 6.51 × 103 ± 0.49; two weeks, 9.06 × 103 ± 1.43, p < 0.05).
Gene_expression (expression) of MHC I in microglial cells
17) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.26 Pain Relevance 0
Also, MHC I expression in iNOS knockout mice was not increased at either 7 or 21 days after axotomy (Figures 2F and 2H), indicating that the absence of MHC I expression in iNOS-/- mice does not represent a delayed response but rather a collateral effect of the gene knockout.
Gene_expression (expression) of MHC I associated with targeted disruption
18) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.25 Pain Relevance 0
Balb/c (H-2K[d]) MHC-I expression remained low and was 1.09±0.40 at day 40 after transplantation.
Gene_expression (expression) of H-2K
19) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.28 Pain Relevance 0
Donor Balb/c (H-2K[d]) MHC-I expression remained low after transplantation until the end of the experiment (Table 2).
Gene_expression (expression) of H-2K
20) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.27 Pain Relevance 0

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