INT69397

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Context Info
Confidence 0.23
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.32
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
microglial cells 4
CD86 2
skeletal muscle 2
cytotoxic T cells 2
H2-K1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 28 96.00 Very High Very High Very High
Inflammation 73 95.60 Very High Very High Very High
spinal inflammation 1 92.40 High High
anesthesia 4 79.04 Quite High
chemokine 8 78.16 Quite High
gABA 8 63.52 Quite High
Neuropeptide 4 61.76 Quite High
Spinal cord 50 59.76 Quite High
Sciatic nerve 44 58.60 Quite High
Inflammatory stimuli 8 15.04 Low Low
Disease Link Frequency Relevance Heat
Adhesions 2 100.00 Very High Very High Very High
Rheumatic Diseases 3 99.16 Very High Very High Very High
Targeted Disruption 46 99.06 Very High Very High Very High
Breast Cancer 23 98.92 Very High Very High Very High
Cancer 100 98.68 Very High Very High Very High
Injury 33 98.12 Very High Very High Very High
Stress 28 97.52 Very High Very High Very High
Skin Cancer 52 97.32 Very High Very High Very High
Arthropathy 1 96.36 Very High Very High Very High
Myositis 42 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following peripheral lesioning, production of NO influences the expression of MHC I in the CNS microenviroment, affecting the synaptic plasticity process.
Regulation (influences) of Gene_expression (expression) of MHC I
1) Confidence 0.23 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.29 Pain Relevance 0.17
The results obtained in the present study reinforce the importance of the MHC I expression by neurons and reactive glia after peripheral injury, and indicate that microglial cells respond to most glial expression of such molecules.
Regulation (importance) of Gene_expression (expression) of MHC I in microglial cells associated with injury
2) Confidence 0.17 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.31 Pain Relevance 0
The role of MHC class I heterodimer expression in mouse ankylosing enthesopathy.
Regulation (role) of Gene_expression (expression) of MHC class I heterodimer associated with rheumatic diseases
3) Confidence 0.12 Published 1997 Journal Immunogenetics Section Title Doc Link 9148786 Disease Relevance 0.92 Pain Relevance 0.09
Following peripheral lesioning, production of NO influences the expression of MHC I in the CNS microenviroment, affecting the synaptic plasticity process.
Regulation (affecting) of Gene_expression (expression) of MHC I
4) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.34 Pain Relevance 0.17
The findings herein indicate that iNOS isoform activity influences MHC I expression by microglial cells one and two weeks after axotomy.
Regulation (influences) of Gene_expression (expression) of MHC I in microglial cells
5) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2885347 Disease Relevance 0.08 Pain Relevance 0.06
-MSH via down-regulation of cell adhesion molecules or MHC class I expression might reduce the migratory capacity of tumor-specific T cells and the interaction between melanoma cells and cytotoxic T cells [46]–[50].
Regulation (regulation) of Gene_expression (expression) of MHC class I in cytotoxic T cells associated with cancer, skin cancer and adhesions
6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 1.34 Pain Relevance 0.11
Using transgenic mice, Nagaraju and colleagues showed that the overexpression of class I major histocompatibility complex antigen (MHC-I) in skeletal muscle fibers was responsible for the chronic activation of the endoplasmic reticulum (ER) stress-response and the development of myositis [4].
Regulation (responsible) of Gene_expression (overexpression) of MHC-I in skeletal muscle associated with stress, targeted disruption and myositis
7) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 1.09 Pain Relevance 0.08
The NSPCs residing in the subventricular zone of the infected brains showed prominent expression of MHC-I and costimulatory molecules CD40, CD80, and CD86.
Regulation (molecules) of Gene_expression (expression) of MHC-I in CD86
8) Confidence 0.03 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2780913 Disease Relevance 0.65 Pain Relevance 0.15
These data suggested that HSVtk gene was expressed in a regulated manner in implanted human breast cancer infected intratumorally with rAAV.


Regulation (regulated) of Gene_expression (expressed) of HSVtk associated with breast cancer
9) Confidence 0.00 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1463003 Disease Relevance 1.29 Pain Relevance 0.08

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