INT69397

Context Info Confidence 0.23 First Reported 1997 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 6.32 Pain Relevance 0.91

Anatomy Link Frequency microglial cells 4 CD86 2 skeletal muscle 2 cytotoxic T cells 2 H2-K1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 28 96.00 Inflammation 73 95.60 spinal inflammation 1 92.40 anesthesia 4 79.04 chemokine 8 78.16 gABA 8 63.52 Neuropeptide 4 61.76 Spinal cord 50 59.76 Sciatic nerve 44 58.60 Inflammatory stimuli 8 15.04

Disease Link Frequency Relevance Heat Adhesions 2 100.00 Rheumatic Diseases 3 99.16 Targeted Disruption 46 99.06 Breast Cancer 23 98.92 Cancer 100 98.68 Injury 33 98.12 Stress 28 97.52 Skin Cancer 52 97.32 Arthropathy 1 96.36 Myositis 42 95.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Following peripheral lesioning, production of NO influences the expression of MHC I in the CNS microenviroment, affecting the synaptic plasticity process.

Regulation (influences) of Gene_expression (expression) of MHC I

1) Confidence 0.23 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.29 Pain Relevance 0.17

The results obtained in the present study reinforce the importance of the MHC I expression by neurons and reactive glia after peripheral injury, and indicate that microglial cells respond to most glial expression of such molecules.

Regulation (importance) of Gene_expression (expression) of MHC I in microglial cells associated with injury

2) Confidence 0.17 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.31 Pain Relevance 0

The role of MHC class I heterodimer expression in mouse ankylosing enthesopathy.

Regulation (role) of Gene_expression (expression) of MHC class I heterodimer associated with rheumatic diseases

3) Confidence 0.12 Published 1997 Journal Immunogenetics Section Title Doc Link 9148786 Disease Relevance 0.92 Pain Relevance 0.09

Following peripheral lesioning, production of NO influences the expression of MHC I in the CNS microenviroment, affecting the synaptic plasticity process.

Regulation (affecting) of Gene_expression (expression) of MHC I

4) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.34 Pain Relevance 0.17

The findings herein indicate that iNOS isoform activity influences MHC I expression by microglial cells one and two weeks after axotomy.

Regulation (influences) of Gene_expression (expression) of MHC I in microglial cells

5) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2885347 Disease Relevance 0.08 Pain Relevance 0.06

-MSH via down-regulation of cell adhesion molecules or MHC class I expression might reduce the migratory capacity of tumor-specific T cells and the interaction between melanoma cells and cytotoxic T cells [46]–[50].

Regulation (regulation) of Gene_expression (expression) of MHC class I in cytotoxic T cells associated with cancer, skin cancer and adhesions

6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 1.34 Pain Relevance 0.11

Using transgenic mice, Nagaraju and colleagues showed that the overexpression of class I major histocompatibility complex antigen (MHC-I) in skeletal muscle fibers was responsible for the chronic activation of the endoplasmic reticulum (ER) stress-response and the development of myositis [4].

Regulation (responsible) of Gene_expression (overexpression) of MHC-I in skeletal muscle associated with stress, targeted disruption and myositis

7) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 1.09 Pain Relevance 0.08

The NSPCs residing in the subventricular zone of the infected brains showed prominent expression of MHC-I and costimulatory molecules CD40, CD80, and CD86.

Regulation (molecules) of Gene_expression (expression) of MHC-I in CD86

8) Confidence 0.03 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2780913 Disease Relevance 0.65 Pain Relevance 0.15

These data suggested that HSVtk gene was expressed in a regulated manner in implanted human breast cancer infected intratumorally with rAAV.

Regulation (regulated) of Gene_expression (expressed) of HSVtk associated with breast cancer

9) Confidence 0.00 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1463003 Disease Relevance 1.29 Pain Relevance 0.08

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