INT69398

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Context Info
Confidence 0.60
First Reported 1997
Last Reported 2011
Negated 3
Speculated 3
Reported most in Body
Documents 14
Total Number 20
Disease Relevance 3.54
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-E)
Anatomy Link Frequency
neuronal 6
primary visual cortex 2
reticulum 2
ventral 2
T-lymphocyte 2
HLA-E (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 42 99.82 Very High Very High Very High
midbrain 6 99.36 Very High Very High Very High
Inflammation 82 98.44 Very High Very High Very High
cytokine 69 97.92 Very High Very High Very High
Substantia nigra 49 96.68 Very High Very High Very High
spinal inflammation 4 94.52 High High
COX2 4 85.24 High High
tetrodotoxin 7 76.40 Quite High
Action potential 2 75.32 Quite High
Spinal cord 7 73.16 Quite High
Disease Link Frequency Relevance Heat
Disease 55 99.84 Very High Very High Very High
Cancer 248 99.20 Very High Very High Very High
Targeted Disruption 37 99.12 Very High Very High Very High
INFLAMMATION 102 98.44 Very High Very High Very High
Ankylosing Spondylitis 1 94.52 High High
Rheumatic Diseases 3 93.28 High High
Arthropathy 1 90.20 High High
Death 55 76.72 Quite High
Malignant Neoplastic Disease 8 74.44 Quite High
Premature Birth 4 74.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether the expression of MHCI molecules is regulated by retinal activity, animals were subjected to monocular enucleation.
Spec (whether) Regulation (regulated) of Gene_expression (expression) of MHC
1) Confidence 0.60 Published 2011 Journal Behav Brain Funct Section Abstract Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
Collectively, the data suggest that the regulation of MHC isoform expression involves a complex interaction of multiple control mechanisms including the myogenin:MyoD and calcineurin:NF-AT pathways; however, other intracellular signaling pathways are likely to contribute.
Regulation (regulation) of Gene_expression (expression) of MHC isoform
2) Confidence 0.47 Published 2000 Journal Muscle Nerve Section Abstract Doc Link 10797389 Disease Relevance 0.11 Pain Relevance 0.19
Expression levels of MHCI molecules are regulated by neuronal activity
Regulation (regulated) of Gene_expression (Expression) of MHC in neuronal
3) Confidence 0.44 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
Expression levels of MHCI molecules are regulated by neuronal activity
Regulation (regulated) of Gene_expression (molecules) of MHC in neuronal
4) Confidence 0.44 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
Recent studies designed to elucidate the mechanisms by which electrical activation and load bearing alter expression of MHC isoforms at the cellular and genetic levels are also reviewed.
Regulation (alter) of Gene_expression (expression) of MHC
5) Confidence 0.34 Published 2000 Journal Muscle Nerve Section Abstract Doc Link 10797389 Disease Relevance 0.13 Pain Relevance 0.21
Independent test of excess MHC dissimilarity in European couples
Neg (Independent) Regulation (Independent) of Gene_expression (dissimilarity) of MHC
6) Confidence 0.30 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2861700 Disease Relevance 0 Pain Relevance 0
0.0253 (see Methods), so that the previously-reported MHC relatedness in Hap2 European mates retains significance (P?
Regulation (reported) of Gene_expression (relatedness) of MHC
7) Confidence 0.30 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2861700 Disease Relevance 0 Pain Relevance 0
The ERAP2 genetic diversity identified here has biological implications in terms of influencing the levels of MHC class I on the cell surface and likely downstream antigen presentation.
Spec (likely) Regulation (influencing) of Gene_expression (levels) of MHC
8) Confidence 0.29 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.39 Pain Relevance 0
These data demonstrate that, in the nonhuman primate brain, expression of MHCI molecules is regulated by neuronal activity.
Regulation (regulated) of Gene_expression (expression) of MHC in neuronal
9) Confidence 0.26 Published 2011 Journal Behav Brain Funct Section Abstract Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
Effects of ERAP2 variants on MHC class I presentation
Regulation (Effects) of Gene_expression (presentation) of MHC
10) Confidence 0.21 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.16 Pain Relevance 0
Here, we present genetic and functional evidence that another gene with a fundamental role in MHC class I presentation, endoplasmic reticulum aminopeptidase 2 (ERAP2), has also evolved under balancing selection and contains a variant that affects antigen presentation.
Regulation (role) of Gene_expression (presentation) of MHC in reticulum
11) Confidence 0.21 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
CIITA, the master regulator of MHC class II expression [41] was induced only in IFN?
Regulation (regulator) of Gene_expression (expression) of MHC
12) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.05 Pain Relevance 0.08
The down-regulation of MHC expression, including the lmp2 gene, is one of the biological mechanisms that tumor cells use to evade host immune surveillance (Swann and Smyth, 2007).
Regulation (regulation) of Gene_expression (expression) of MHC associated with cancer
13) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.55 Pain Relevance 0
Regulation of the expression of MHC-II genes is highly complex, and this tight control directly affects the T-lymphocyte activation and thus the modulation of the immune response.
Regulation (Regulation) of Gene_expression (expression) of MHC in T-lymphocyte
14) Confidence 0.05 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC425594 Disease Relevance 0.30 Pain Relevance 0.03
-syn-neurodegeneration group, we observed at 4 weeks a significant robust up-regulation of MHC II expression in the ventral midbrain, where the area immunostained for MHC II covered the full SN (both SNc and SNr) (Table 1 & Figure 6A).
Regulation (regulation) of Gene_expression (expression) of MHC in ventral associated with substantia nigra and midbrain
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808388 Disease Relevance 0.14 Pain Relevance 0.22
To investigate the role of major histocompatibility complex (MHC) class I expression in disease pathogenesis, ANKENT occurrence was compared among beta2-microglobulin (beta2m) knockout littermates with or without transgenes for HLA-B*2702 and human beta2m.
Spec (investigate) Regulation (role) of Gene_expression (expression) of MHC associated with targeted disruption and disease
16) Confidence 0.04 Published 1997 Journal Immunogenetics Section Abstract Doc Link 9148786 Disease Relevance 0.87 Pain Relevance 0.09
As shown in Fig. 5, aspirin did not affect the expression of MHC class I or class II molecules.
Neg (not) Regulation (affect) of Gene_expression (expression) of MHC associated with aspirin
17) Confidence 0.03 Published 2010 Journal Immune Network Section Body Doc Link PMC2902675 Disease Relevance 0 Pain Relevance 0.25
Activity-dependent regulation of MHC class I expression in the developing primary visual cortex of the common marmoset monkey

Background

Regulation (regulation) of Gene_expression (expression) of MHC in primary visual cortex
18) Confidence 0.03 Published 2011 Journal Behav Brain Funct Section Title Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
Several dogmas should be re-assessed such as, for instance the relevance of MHC expression down-regulation and its relationship with that of pro-inflammatory cytokines such as IFN-?
Regulation (regulation) of Gene_expression (expression) of MHC associated with inflammation and cytokine
19) Confidence 0.03 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 0.72 Pain Relevance 0.14
However, we believe that any effects of steroids are likely to be minor, given that they had no effect on MHC II expression in a previous study (Lloyd et al., 2007).
Neg (no) Regulation (effect) of Gene_expression (expression) of MHC
20) Confidence 0.02 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.13 Pain Relevance 0.06

General Comments

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