INT69422

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Context Info
Confidence 0.43
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.96
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN1) extracellular region (EDN1) cell-cell signaling (EDN1)
cytoplasm (EDN1)
Anatomy Link Frequency
plasma 4
EDN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 2 100.00 Very High Very High Very High
Dynorphin 1 96.84 Very High Very High Very High
reflex sympathetic dystrophy 21 89.64 High High
narcan 2 89.60 High High
cytokine 11 87.56 High High
Inflammation 12 87.16 High High
noradrenaline 2 84.80 Quite High
Opioid 1 75.00 Quite High
Mcgill questionnaire 1 72.48 Quite High
Endogenous opioid 1 57.60 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 1 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 7 91.28 High High
Complex Regional Pain Syndromes 24 89.64 High High
Disease 16 88.16 High High
INFLAMMATION 14 87.16 High High
Stress 1 75.00 Quite High
Pain 6 71.92 Quite High
Blister 23 50.00 Quite Low
Reprotox - General 2 1 37.76 Quite Low
Hyperalgesia 2 35.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is unclear what the effect of disuse on the production of ET-1 and NO could be, but the plasma NOx concentration in healthy young humans significantly increases after exercise, with a significant decrease of ET-1 [41].
Positive_regulation (increases) of Negative_regulation (decrease) of ET-1 in plasma
1) Confidence 0.43 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693561 Disease Relevance 0.79 Pain Relevance 0.54
During MAT, low responders showed significantly (p < 0.01) increased plasma levels of beta-endorphin, cortisol, catecholamines, and atrial natriuretic factor (ANF) and decreased levels of endothelin-1, whereas high responders showed increased (p < 0.01) levels of Metenkephalin, dynorphin B, and catecholamines.
Positive_regulation (increased) of Negative_regulation (decreased) of endothelin-1 in plasma associated with natriuresis, dynorphin and catecholamine
2) Confidence 0.36 Published 1997 Journal Peptides Section Abstract Doc Link 9149287 Disease Relevance 0.17 Pain Relevance 0.40

General Comments

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