INT6943

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Context Info
Confidence 0.70
First Reported 1988
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 71
Total Number 76
Disease Relevance 17.36
Pain Relevance 35.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gabrd)
Anatomy Link Frequency
neurons 7
neuronal 4
brain 3
PAG 1
nucleus 1
Gabrd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 592 100.00 Very High Very High Very High
adenocard 297 100.00 Very High Very High Very High
central sensitization 5 99.90 Very High Very High Very High
antinociception 52 99.84 Very High Very High Very High
agonist 204 99.80 Very High Very High Very High
opioid receptor 8 99.80 Very High Very High Very High
midbrain 10 99.72 Very High Very High Very High
depression 141 99.70 Very High Very High Very High
antagonist 374 99.60 Very High Very High Very High
nociceptor 19 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 74 100.00 Very High Very High Very High
Depression 139 99.70 Very High Very High Very High
Urological Neuroanatomy 63 99.54 Very High Very High Very High
Temporomandibular Joint Syndrome 18 99.20 Very High Very High Very High
INFLAMMATION 134 98.86 Very High Very High Very High
Erectile Dysfunction 6 98.84 Very High Very High Very High
Hypoalagesia 4 98.84 Very High Very High Very High
Hypothermia 8 98.80 Very High Very High Very High
Pain 93 98.24 Very High Very High Very High
Neuropathic Pain 141 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus we conclude that pentobarbitone, but not propofol, produced pre-emptive analgesia in this model, presumably by suppressing noxious stimulation-induced central sensitization via activation of GABAA receptors.
Positive_regulation (activation) of GABAA associated with central sensitization and analgesia
1) Confidence 0.70 Published 1994 Journal Br J Anaesth Section Abstract Doc Link 8024913 Disease Relevance 0.38 Pain Relevance 0.85
At concentrations up to 100 microM, pentobarbital did not directly activate GABAA receptors.
Neg (not) Positive_regulation (activate) of GABAA
2) Confidence 0.70 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580945 Disease Relevance 0 Pain Relevance 0.20
This study provides behavioral and electrophysiological evidence for the important role of the loss of spinal inhibitory tone, mediated by activation of both GABAA and GABAB receptors, in the development of central neuropathic pain following SCI.
Positive_regulation (activation) of GABAA in spinal associated with frailty and neuropathic pain
3) Confidence 0.69 Published 2006 Journal J. Neurotrauma Section Abstract Doc Link 16866624 Disease Relevance 0.78 Pain Relevance 0.89
CONCLUSIONS: Propofol at clinically relevant concentrations directly activates the GABAA receptor-chloride ionophore complex in the mammalian central neurons and, hence, increases the chloride conductance, which may contribute to anesthesia produced by the agent.
Positive_regulation (activates) of GABAA receptor in neurons
4) Confidence 0.68 Published 1993 Journal Anesthesiology Section Body Doc Link 8214758 Disease Relevance 0 Pain Relevance 0
GABAA receptor activity is enhanced, leading to increased charge transfer and prolonged synaptic inhibition, and members of the two pore domain family of potassium channels are activated, leading to neuronal hyperpolarization and reduced excitability.
Positive_regulation (enhanced) of GABAA receptor in neuronal associated with potassium channel
5) Confidence 0.64 Published 2000 Journal J Basic Clin Physiol Pharmacol Section Abstract Doc Link 11037765 Disease Relevance 0 Pain Relevance 0.12
[K+]o elevations were recorded in the entorhinal cortex during the ictal discharge (peak values = 13.9 +/- 0.9 mM) and the synchronous GABA-mediated potentials (peak values = 4.2 +/- 0.1 mM); the latter increases were presumably attributable to postsynaptic GABAa-receptor activation because they were abolished by DAGO or BMI.
Positive_regulation (activation) of GABAa-receptor in cortex associated with gaba
6) Confidence 0.62 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8656285 Disease Relevance 0.07 Pain Relevance 0.65
Propofol activates GABAA receptor-chloride ionophore complex in dissociated hippocampal pyramidal neurons of the rat.
Positive_regulation (activates) of GABAA receptor in pyramidal neurons associated with pyramidal cell
7) Confidence 0.60 Published 1993 Journal Anesthesiology Section Title Doc Link 8214758 Disease Relevance 0 Pain Relevance 0.19
Our results suggest that activation of peripheral GABAA receptors located within the TMJ region could act to decrease the transmission of nociceptive information.
Positive_regulation (activation) of GABAA in TMJ associated with nociception and snapping jaw
8) Confidence 0.51 Published 1999 Journal J. Neurophysiol. Section Abstract Doc Link 10200231 Disease Relevance 0.78 Pain Relevance 1.09
The aims of this study were to determine if local GABAA receptor activation modifies corneal input to second-order neurons at these regions and if GABAA receptor activation in one region affects corneal input to the other region.
Positive_regulation (activation) of GABAA in neurons
9) Confidence 0.50 Published 2003 Journal J. Neurophysiol. Section Abstract Doc Link 12890797 Disease Relevance 0 Pain Relevance 0.30
Overall, our results suggest the presence of two central GABA pathways which mediate opposite effects: (a) a bicuculline-sensitive GABAA-receptor, the stimulation of which increases acid secretion under pharmacological depression of central vagal tone (anaesthetized rats); (b) a phaclofen-sensitive GABAB-receptor, the activation of which decreases vagally stimulated acid secretion (pylorus-ligated rats).
Positive_regulation (bicuculline-sensitive) of GABAA-receptor in pylorus associated with gaba and depression
10) Confidence 0.49 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2155808 Disease Relevance 0.10 Pain Relevance 0.17
These changes were also associated with significant two and threefold increases in both the mRNA and protein for the alpha4 subunit of the GABAA receptor, respectively, in hippocampus.
Positive_regulation (increases) of GABAA receptor in hippocampus associated with hippocampus
11) Confidence 0.49 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9651210 Disease Relevance 0.20 Pain Relevance 0.53
In female rats, withdrawal from prolonged dosing with progesterone leads to upregulation of alpha4 and delta subunits of the GABAA receptor in several brain regions.
Positive_regulation (upregulation) of GABAA in brain associated with withdrawal
12) Confidence 0.47 Published 2006 Journal Exp. Physiol. Section Abstract Doc Link 16740643 Disease Relevance 0.28 Pain Relevance 0.23
The hypothermia induced by GABA-agonists appears to be due to simultaneous activation of GABAA and GABAB receptors, while the hyperthermic effect of baclofen appears to be due to stimulation of GABAB receptors. 8.
Positive_regulation (activation) of GABAA associated with hypothermia, gaba and agonist
13) Confidence 0.46 Published 1991 Journal Gen. Pharmacol. Section Abstract Doc Link 1647343 Disease Relevance 0.35 Pain Relevance 0.80
In the previous report, we had shown that blockade and enhancement of GABAA receptors in the DMH of rats increased or decreased the level of anxiety, respectively, as measured by the elevated plus-maze test.
Positive_regulation (enhancement) of GABAA associated with anxiety disorder
14) Confidence 0.43 Published 1993 Journal Brain Res. Section Abstract Doc Link 8293298 Disease Relevance 0.25 Pain Relevance 0.04
The inhibitory action of clonidine blockable by yohimbine (10(-4) mol/L) was voltage-independent and did not change the membrane conductance during the activation of GABAA receptor.
Positive_regulation (activation) of GABAA receptor associated with clonidine
15) Confidence 0.42 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324513 Disease Relevance 0.21 Pain Relevance 0.96
Our results suggest that norfloxacin and related piperazinoquinolones, acting at GABAA receptors, may induce a high affinity binding site for indomethacin/ibuprofen-like anti-inflammatory agents (the AAA site) that, when occupied, reciprocally increases the affinities of the quinolones for GABAA receptors.
Positive_regulation (increases) of GABAA associated with inflammation
16) Confidence 0.39 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8388990 Disease Relevance 0.32 Pain Relevance 0.22
In the PAG, a region involved in mediating panic-like anxiety, alpha4, beta1 and delta GABAA receptor subunits are located principally on GABAergic interneurones.
Positive_regulation (mediating) of GABAA in PAG associated with gabaergic, anxiety disorder and urological neuroanatomy
17) Confidence 0.38 Published 2006 Journal Exp. Physiol. Section Abstract Doc Link 16740643 Disease Relevance 0.50 Pain Relevance 0.42
These results are consistent with NPA promoting nonvesicular release of GABA from neighboring neurons or glia via reverse operation of the GABA uptake system, which then activated GABAA receptors on the recorded neurons.
Positive_regulation (activated) of GABAA in neurons associated with gaba
18) Confidence 0.37 Published 1995 Journal Epilepsy Res. Section Abstract Doc Link 7796791 Disease Relevance 0.06 Pain Relevance 0.94
Activation of peripheral GABAA receptors inhibits temporomandibular joint-evoked jaw muscle activity.
Positive_regulation (Activation) of GABAA in muscle associated with snapping jaw
19) Confidence 0.37 Published 1999 Journal J. Neurophysiol. Section Title Doc Link 10200231 Disease Relevance 0.70 Pain Relevance 1.01
The ratios of the mean gold particle densities over the boutons that were presynaptic to the selected GABAA receptor ?
Positive_regulation (selected) of GABAA receptor in boutons
20) Confidence 0.36 Published 2008 Journal Neuroscience Section Body Doc Link PMC2553186 Disease Relevance 0.15 Pain Relevance 0.19

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