INT69435

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Context Info
Confidence 0.51
First Reported 1997
Last Reported 2011
Negated 1
Speculated 3
Reported most in Body
Documents 74
Total Number 77
Disease Relevance 50.38
Pain Relevance 13.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) plasma membrane (ROS1)
Anatomy Link Frequency
skin 3
neutrophils 2
Spinal cord 2
granulocytes 2
Macrophages 1
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 94 100.00 Very High Very High Very High
Spinal cord 106 99.98 Very High Very High Very High
qutenza 92 99.92 Very High Very High Very High
Inflammation 804 99.72 Very High Very High Very High
ischemia 80 99.60 Very High Very High Very High
antagonist 71 99.52 Very High Very High Very High
Arthritis 73 99.40 Very High Very High Very High
long-term potentiation 38 99.32 Very High Very High Very High
isoflurane 14 99.30 Very High Very High Very High
Serotonin 14 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1569 100.00 Very High Very High Very High
Apoptosis 816 100.00 Very High Very High Very High
Injury 282 99.98 Very High Very High Very High
Hypoxia 152 99.98 Very High Very High Very High
Neurodegenerative Disease 60 99.84 Very High Very High Very High
Parkinson's Disease 68 99.74 Very High Very High Very High
INFLAMMATION 866 99.72 Very High Very High Very High
Increased Venous Pressure Under Development 97 99.68 Very High Very High Very High
Cv Unclassified Under Development 76 99.60 Very High Very High Very High
Adhesions 86 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduction of the basal generation of ROS may play a role in the induction of apoptosis by capsaicin.
Negative_regulation (Reduction) of ROS associated with qutenza and apoptosis
1) Confidence 0.51 Published 2000 Journal Cancer Lett. Section Abstract Doc Link 11078921 Disease Relevance 0.83 Pain Relevance 0.79
Mechanical removal of ROS in IVF/ET has been examined [186].
Negative_regulation (removal) of ROS
2) Confidence 0.43 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.46 Pain Relevance 0.12
The presence of ROS and ROS-sensitive transcription factor EGR-1 was also evident in an experimental rodent peritoneal adhesion model.
Negative_regulation (presence) of ROS associated with adhesions
3) Confidence 0.42 Published 2004 Journal World J Surg Section Abstract Doc Link 14961185 Disease Relevance 1.42 Pain Relevance 0.06
Because this pattern of gene expression is suggestive of a high intrinsic OS status in vulnerable neurons, despite their location in different regions of the brain, it appears that a commonality among these various types of neurons is an endogenously high level of ROS/RNS formation.
Negative_regulation (level) of ROS in brain associated with stress
4) Confidence 0.39 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.42 Pain Relevance 0.14
Furthermore, lidocaine and mepivacaine failed to reduce ROS generated by the cell-free system.
Neg (failed) Negative_regulation (reduce) of ROS
5) Confidence 0.38 Published 1997 Journal Acta Anaesthesiol Scand Section Body Doc Link 9150783 Disease Relevance 0 Pain Relevance 0
The capsaicin-induced generation of ROS and apoptosis was significantly suppressed by treatment with antioxidants, DPPD and tocopherol.
Negative_regulation (suppressed) of ROS associated with qutenza and apoptosis
6) Confidence 0.36 Published 2004 Journal Free Radic. Res. Section Abstract Doc Link 15190937 Disease Relevance 1.17 Pain Relevance 0.83
They can also act directly by suppressing ROS formation (30).


Negative_regulation (suppressing) of ROS
7) Confidence 0.35 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1697746 Disease Relevance 0.77 Pain Relevance 0.05
Controversy remains as to whether hypoxia decreases or increases ROS and which electron transport chain complex generates the ROS (I and/or III).
Spec (whether) Negative_regulation (decreases) of ROS associated with hypoxia
8) Confidence 0.35 Published 2005 Journal J. Appl. Physiol. Section Abstract Doc Link 15591309 Disease Relevance 1.06 Pain Relevance 0.15
In the hippocampus, astrocytes in the CA1 region under ischemia, display selective loss of glutamate transport activity, increased mitochondrial ROS generation, and reduced mitochondrial membrane potential.
Negative_regulation (loss) of ROS in hippocampus associated with glutamate, ischemia and hippocampus
9) Confidence 0.34 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.78 Pain Relevance 0.39
Thus, inhibiting NO or ROS may be a potential target in blocking morphine-induced apoptosis of endothelial cells.
Negative_regulation (inhibiting) of ROS in endothelial cells associated with apoptosis and morphine
10) Confidence 0.34 Published 2009 Journal Toxicology Section Abstract Doc Link 19070643 Disease Relevance 0.66 Pain Relevance 0.92
Enzymatic antioxidants are also known as natural antioxidants, they neutralize excessive ROS and prevent it from damaging the cellular structure.
Negative_regulation (neutralize) of ROS
11) Confidence 0.32 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0 Pain Relevance 0.11
Further evaluation at higher toxic dosages with Hep G2 cells for ROS and glutathione depletion and HeLa cells for calcein uptake, demonstrated toxic effects for 56 of the 100 reference compounds in these assays, among which there were estrogens, androgens, progestagens and antiestrogens.
Negative_regulation (depletion) of ROS in HeLa
12) Confidence 0.31 Published 2005 Journal Toxicol In Vitro Section Abstract Doc Link 15826808 Disease Relevance 0.16 Pain Relevance 0.07
Thus, inhibition of ROS generation centrally and perhaps peripherally improves the adverse nociceptive outcomes in this model.
Negative_regulation (inhibition) of ROS associated with nociception
13) Confidence 0.30 Published 2010 Journal Mol Pain Section Body Doc Link PMC2924298 Disease Relevance 0.47 Pain Relevance 0.34
Direct exposure of human spermatozoa to ROS disrupts not only the functional competence of these cells but also their genomic integrity [24].
Negative_regulation (disrupts) of ROS in spermatozoa
14) Confidence 0.29 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1315356 Disease Relevance 0.31 Pain Relevance 0
ROS scavengers and caspase inhibitor were used to determine the roles of ROS and apoptosis in the effects of saikosaponins on cisplatin-induced cell death.


Negative_regulation (inhibitor) of ROS associated with apoptosis and death
15) Confidence 0.25 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC3006358 Disease Relevance 1.37 Pain Relevance 0
Kaempferol has also been found to be a blocker of reactive oxygen species (ROS) production by low K+-induced apoptosis in cerebella granule cells.[27] According to previous reports, antioxidant activity of kaempferol was believed to have cytoprotective function against oxidative stress.
Negative_regulation (blocker) of ROS in granule cells associated with stress and apoptosis
16) Confidence 0.24 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2881656 Disease Relevance 0.73 Pain Relevance 0.03
In addition, CD45 has long been shown to be relevant for LTB4- and C5a-induced chemotaxis and low affinity FcãR signalling in neutrophils [258,259]: since ROS have been shown to be potent inhibitors of CD45 [260], they may interfere with physiological responses to these chemoattractants.
Negative_regulation (inhibitors) of ROS in neutrophils
17) Confidence 0.23 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.29 Pain Relevance 0.12
ROS and oxidative stress in relation to CLD aetiology
Negative_regulation (stress) of ROS associated with stress
18) Confidence 0.23 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.58 Pain Relevance 0.04
ROS and oxidative stress-related reactive intermediates in NAFLD and NASH: their generation and role in causing steatosis
Negative_regulation (stress) of ROS associated with fatty liver, stress and nash(non-alcoholic steatohepatitis)
19) Confidence 0.23 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.53 Pain Relevance 0.14
Second, ROS-mediated inhibitory modulation of the activity of PTPs (for example, CD45, SHP-1, HePTP) has been shown to regulate signalling events involved in the activation of T lymphocytes [256,257].
Negative_regulation (modulation) of ROS-mediated in T lymphocytes
20) Confidence 0.23 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.42 Pain Relevance 0.16

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