INT69437

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Context Info
Confidence 0.58
First Reported 1997
Last Reported 2011
Negated 3
Speculated 7
Reported most in Body
Documents 328
Total Number 335
Disease Relevance 222.83
Pain Relevance 40.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) plasma membrane (ROS1)
Anatomy Link Frequency
respiratory 6
neutrophils 6
lung 6
spermatozoa 4
blood 4
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 3718 100.00 Very High Very High Very High
cytokine 1624 100.00 Very High Very High Very High
central sensitization 82 100.00 Very High Very High Very High
Lasting pain 17 100.00 Very High Very High Very High
Spinal cord 357 99.98 Very High Very High Very High
qutenza 310 99.98 Very High Very High Very High
Glutamate 333 99.84 Very High Very High Very High
Potency 42 99.84 Very High Very High Very High
visual analogue scale 1 99.80 Very High Very High Very High
depression 226 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4155 100.00 Very High Very High Very High
Pain 208 100.00 Very High Very High Very High
Hypoxia 208 100.00 Very High Very High Very High
Iron Overload 161 100.00 Very High Very High Very High
Stress 7288 99.98 Very High Very High Very High
Infection 1817 99.98 Very High Very High Very High
Hyperglycemia 300 99.98 Very High Very High Very High
Pancreatitis 11 99.98 Very High Very High Very High
Endotoxemia 29 99.96 Very High Very High Very High
Parkinson's Disease 281 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin at the concentration of inducing apoptosis also markedly increased the level of ROS.
Positive_regulation (increased) of ROS associated with qutenza and apoptosis
1) Confidence 0.58 Published 2004 Journal Free Radic. Res. Section Abstract Doc Link 15190937 Disease Relevance 1.17 Pain Relevance 0.82
Increases in TRPV1 and ROS, generated by synoviocytes in vitro, were reciprocally blocked by TRPV1 antagonists and the ROS scavenger.
Positive_regulation (Increases) of ROS
2) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link 20691059 Disease Relevance 0 Pain Relevance 0
In the hippocampus, astrocytes in the CA1 region under ischemia, display selective loss of glutamate transport activity, increased mitochondrial ROS generation, and reduced mitochondrial membrane potential.
Positive_regulation (increased) of ROS in hippocampus associated with glutamate, ischemia and hippocampus
3) Confidence 0.55 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.77 Pain Relevance 0.36
SOD activity decreases in the late secretory phase while ROS levels increase [100].
Positive_regulation (increase) of ROS
4) Confidence 0.51 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.46 Pain Relevance 0.10
ROS generation was monitored with ROS sensitive dyes using live cell imaging in vitro and in spinal tissue histology, as well as with measurement of ROS metabolites in culture media using HPLC.
Positive_regulation (generation) of ROS in spinal associated with imagery
5) Confidence 0.50 Published 2010 Journal Mol Pain Section Abstract Doc Link 20691059 Disease Relevance 0.17 Pain Relevance 0.09
Emerging evidence indicates that pancreatitis-inducing ROS/RNS generation may be attenuated by targeting ROS/RNS-generating enzymes and upstream mediators.
Positive_regulation (inducing) of ROS associated with pancreatitis
6) Confidence 0.49 Published 2009 Journal Antioxid. Redox Signal. Section Abstract Doc Link 18837654 Disease Relevance 0.57 Pain Relevance 0.28
While spermatozoa certainly generate ROS, the biochemical basis of this activity is uncertain and may be multifactorial.
Positive_regulation (generate) of ROS in spermatozoa
7) Confidence 0.47 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1315356 Disease Relevance 0.64 Pain Relevance 0
In addition to NADPH oxidase activity, it is also clear that spermatozoa will generate ROS when placed in contact with certain xenobiotics.
Positive_regulation (generate) of ROS in spermatozoa
8) Confidence 0.47 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1315356 Disease Relevance 0.08 Pain Relevance 0
The endogenous ROS levels were increased during HepG2 apoptosis, whereas they were decreased during SK-N-SH apoptosis in response to capsaicin treatments.
Positive_regulation (increased) of ROS in SK-N-SH associated with qutenza and apoptosis
9) Confidence 0.43 Published 2008 Journal Proteomics Section Abstract Doc Link 18991268 Disease Relevance 0.55 Pain Relevance 0.38
Most importantly, sulindac-derived ROS activated p38 mitogen-activated protein kinase and p53.
Positive_regulation (sulindac-derived) of ROS
10) Confidence 0.41 Published 2007 Journal Apoptosis Section Abstract Doc Link 17136320 Disease Relevance 1.27 Pain Relevance 0.06
ROS production was assessed by the peak time (PT) of ROS production and area under the luminol reaction curve (AUC), which represents total ROS production quantity against opsonized zymosan stimuli.
Positive_regulation (represents) of ROS
11) Confidence 0.41 Published 2010 Journal J. Vet. Med. Sci. Section Abstract Doc Link 19940395 Disease Relevance 0.13 Pain Relevance 0.25
Arachidonic acid was also found to increase ROS generation, and could synergize with indomethacin in this reaction.
Positive_regulation (increase) of ROS
12) Confidence 0.41 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9540818 Disease Relevance 0.57 Pain Relevance 0.55
Furthermore, lidocaine and mepivacaine failed to reduce ROS generated by the cell-free system.
Positive_regulation (generated) of ROS
13) Confidence 0.41 Published 1997 Journal Acta Anaesthesiol Scand Section Body Doc Link 9150783 Disease Relevance 0 Pain Relevance 0
Finally, the intracellular reactive oxygen species (ROS), especially hydrogen peroxide (H(2)O(2)) and superoxide anion (O(2)(-)), were found to be elevated after treatment of these cells with Baizhu extracts.
Positive_regulation (elevated) of ROS
14) Confidence 0.40 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 15652270 Disease Relevance 0.97 Pain Relevance 0.07
Saikosaponins induce intracellular ROS accumulation in cancer cells
Positive_regulation (accumulation) of ROS associated with cancer
15) Confidence 0.40 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 0.53 Pain Relevance 0
These results suggest that induction of ROS is crucial for saikosaponins' potentiation effect on cisplatin-induced cytotoxicity in cancer cells.


Positive_regulation (induction) of ROS associated with cancer
16) Confidence 0.40 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 0.82 Pain Relevance 0
We next investigated whether the ROS accumulation is required for the potentiated cytotoxicity induced by saikosaponins and cisplatin co-treatment.
Spec (whether) Positive_regulation (accumulation) of ROS
17) Confidence 0.40 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 0.32 Pain Relevance 0
Many naturally occurring compounds have been reported to exert anti-cancer effect through ROS induction.
Positive_regulation (induction) of ROS associated with cancer
18) Confidence 0.40 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 0.81 Pain Relevance 0
ROS accumulation contributes to the synergistic cytotoxicity induced by saikosaponins plus cisplatin
Positive_regulation (accumulation) of ROS
19) Confidence 0.40 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 0.31 Pain Relevance 0
ROS such as superoxide anion (.O2-) and its reduced product hydrogen peroxide (H2O2) have been considered as cytotoxic byproducts of cellular metabolism, and the accumulation of ROS in cells may promote cell death.
Positive_regulation (accumulation) of ROS associated with death
20) Confidence 0.40 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 0.48 Pain Relevance 0

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