INT69439

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Context Info
Confidence 0.45
First Reported 1997
Last Reported 2011
Negated 3
Speculated 5
Reported most in Body
Documents 46
Total Number 51
Disease Relevance 31.22
Pain Relevance 6.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) plasma membrane (ROS1)
Anatomy Link Frequency
SH-SY5Y 3
body 2
chondrocyte 1
plasma 1
liver 1
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 320 100.00 Very High Very High Very High
addiction 15 100.00 Very High Very High Very High
Opioid 13 99.44 Very High Very High Very High
cINOD 56 99.36 Very High Very High Very High
Osteoarthritis 70 99.32 Very High Very High Very High
cocaine 292 99.16 Very High Very High Very High
agonist 67 98.98 Very High Very High Very High
ischemia 36 98.96 Very High Very High Very High
cytokine 209 97.12 Very High Very High Very High
metalloproteinase 32 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1188 100.00 Very High Very High Very High
Apoptosis 937 100.00 Very High Very High Very High
Parkinson's Disease 23 99.96 Very High Very High Very High
Liver Disease 215 99.64 Very High Very High Very High
Skin Cancer 16 99.56 Very High Very High Very High
Osteoarthritis 77 99.32 Very High Very High Very High
Death 425 99.20 Very High Very High Very High
Coronary Artery Disease 77 99.20 Very High Very High Very High
Injury 304 99.04 Very High Very High Very High
Cv Unclassified Under Development 39 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reference values for ROS and NOS, minimum safe concentrations or physiologically beneficial concentrations have yet not been defined.
Regulation (values) of ROS
1) Confidence 0.45 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 1.44 Pain Relevance 0
OBJECTIVE: To establish a role of increased reactive oxygen species (ROS) in the mechanism of cancer killing by sulindac in the presence of an oxidizing agent.
Regulation (role) of ROS
2) Confidence 0.37 Published 2009 Journal J Drugs Dermatol Section Body Doc Link 19180893 Disease Relevance 0.19 Pain Relevance 0
As our understanding the role ROS-induced angiogenesis plays in atherosclerosis and myocardial angiogenesis grows, future studies should investigate the role ROS plays in the angiogenesis in the female reproductive tract.

2.4 Reactive oxygen species and the endometrium

Regulation (role) of ROS in endometrium associated with increased venous pressure under development
3) Confidence 0.33 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.47 Pain Relevance 0.09
Thus, one cannot exclude the possibility of UCP2 being involved in cell senescence in T2D as reflected by the telomere dynamics here, through a pathway triggered by disturbed insulin secretion in addition or not to disturbed regulation of ROS.
Neg (not) Regulation (regulation) of ROS in telomere associated with aging and diabetes mellitus
4) Confidence 0.27 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 1.17 Pain Relevance 0
The inhibition effect of ROS scavengers on cell death was correlated with significant reduction of .O2- and H2O2 levels in cells (Figure 4C and 4D).
Regulation (effect) of ROS associated with death
5) Confidence 0.26 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 0.41 Pain Relevance 0
ROS and intracellular signalling cascades: redox sensitive molecular targets in signalling pathways likely to be involved in chronic wound healing
Regulation (molecular) of ROS associated with wound healing
6) Confidence 0.24 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.48 Pain Relevance 0.13
Data on acute liver injury should imply that during CLDs tissue levels of ROS and other mediators are likely to be lower; this has been shown for HNE levels, which ranged from 1–3 ?
Spec (likely) Regulation (likely) of ROS in liver associated with liver disease and injury
7) Confidence 0.24 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.01 Pain Relevance 0.15
ROS and intracellular signalling cascades: redox sensitive molecular targets in signalling pathways likely to be involved in chronic wound healing
Regulation (sensitive) of ROS associated with wound healing
8) Confidence 0.24 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.48 Pain Relevance 0.13
The ability of these NSAIDs and short-chain fatty acids to alter cellular ROS metabolism may contribute to their chemopreventive activity.
Regulation (alter) of ROS associated with cinod
9) Confidence 0.24 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9540818 Disease Relevance 0.45 Pain Relevance 0.51
However, these local anaesthetics at clinically relevant blood concentrations had no effect on the levels of ROS.
Neg (no) Regulation (effect) of ROS in blood
10) Confidence 0.24 Published 1997 Journal Acta Anaesthesiol Scand Section Body Doc Link 9150783 Disease Relevance 0 Pain Relevance 0
We discuss pathogenic factors that can influence clinical expression, especially ATP shortage and reactive oxygen radicals (ROS) excess.
Regulation (influence) of ROS
11) Confidence 0.21 Published 2009 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 20225024 Disease Relevance 0.27 Pain Relevance 0.09
MS, PD, and T2DM are associated with multiple metabolic toxicities, which are responsible for reactive oxygen species (ROS) production (table 3).
Regulation (responsible) of ROS associated with diabetes mellitus, prediabetic state and metabolic syndrome
12) Confidence 0.19 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 1.80 Pain Relevance 0.22
It is considerably more practical to measure the 'footprints' of ROS and RNS, such as their effects on various lipids, proteins, and nucleic acids.
Regulation (effects) of ROS
13) Confidence 0.18 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 0.98 Pain Relevance 0.32
Cells contain antioxidant enzymes to regulate steady state levels of ROS produced by products of metabolism.
Regulation (regulate) of ROS
14) Confidence 0.15 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12649190 Disease Relevance 0.58 Pain Relevance 0.09
This will include ready-to-use key information and concepts on ROS, free radicals and oxidative stress-related reactive intermediates and reactions, sources of ROS in mammalian cells and tissues, antioxidant defences, redox sensors and, more generally, the major principles of redox signalling and redox-dependent transcriptional regulation of mammalian cells.
Regulation (regulation) of ROS associated with stress
15) Confidence 0.14 Published 2008 Journal Fibrogenesis Tissue Repair Section Abstract Doc Link PMC2584013 Disease Relevance 1.11 Pain Relevance 0.08
This will include ready-to-use key information and concepts on ROS, free radicals and oxidative stress-related reactive intermediates and reactions, sources of ROS in mammalian cells and tissues, antioxidant defences, redox sensors and, more generally, the major principles of redox signalling and redox-dependent transcriptional regulation of mammalian cells.
Regulation (regulation) of ROS associated with stress
16) Confidence 0.14 Published 2008 Journal Fibrogenesis Tissue Repair Section Abstract Doc Link PMC2584013 Disease Relevance 1.03 Pain Relevance 0.08
Interestingly, reactive oxygen species

(ROS) and cellular oxidative stress have long been implicated in

Regulation (implicated) of ROS associated with stress
17) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2464819 Disease Relevance 0.46 Pain Relevance 0
Effect of Diclofenac on the Intracellular ROS Level
Regulation (Effect) of ROS associated with diclofenac
18) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.37 Pain Relevance 0.44
These results prompted us to evaluate the downstream effects of altered ROS levels in the course of diclofenac treatment of SH-SY5Y cells.
Regulation (effects) of ROS in SH-SY5Y associated with diclofenac
19) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.60 Pain Relevance 0.20
Therefore, we have decided to investigate whether diclofenac affects the intracellular ROS levels also in SH-SY5Y cells, using the fluorescent probe DCFH-DA.
Spec (whether) Regulation (affects) of ROS in SH-SY5Y associated with diclofenac
20) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.34 Pain Relevance 0.41

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