INT69440

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2011
Negated 4
Speculated 12
Reported most in Abstract
Documents 752
Total Number 770
Disease Relevance 477.64
Pain Relevance 103.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) plasma membrane (ROS1)
Anatomy Link Frequency
neutrophils 31
monocytes 15
spermatozoa 15
leukocytes 13
macrophages 12
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8760 100.00 Very High Very High Very High
cytokine 3473 100.00 Very High Very High Very High
Spinal cord 612 100.00 Very High Very High Very High
Central nervous system 415 100.00 Very High Very High Very High
Inflammatory mediators 295 100.00 Very High Very High Very High
intrathecal 91 99.98 Very High Very High Very High
ischemia 804 99.96 Very High Very High Very High
Fibrositis 988 99.84 Very High Very High Very High
qutenza 494 99.84 Very High Very High Very High
cocaine 2628 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 15904 100.00 Very High Very High Very High
INFLAMMATION 9867 100.00 Very High Very High Very High
Insulin Resistance 851 100.00 Very High Very High Very High
Malaria 219 100.00 Very High Very High Very High
Diabetes Mellitus 4381 99.98 Very High Very High Very High
Disease 5446 99.96 Very High Very High Very High
Cv Unclassified Under Development 977 99.96 Very High Very High Very High
Arthritis 797 99.96 Very High Very High Very High
Prediabetic State 395 99.92 Very High Very High Very High
Apoptosis 8690 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MEASUREMENTS AND MAIN RESULTS: Thiopental-treated lymphocytes exhibited an overgeneration of ROS, but no change was detected in mitochondrial glutathione quantity.
Gene_expression (overgeneration) of ROS in lymphocytes
1) Confidence 0.78 Published 2004 Journal J Clin Anesth Section Body Doc Link 15217658 Disease Relevance 0 Pain Relevance 0
ROS generation may play a part in the exposure of PS.
Gene_expression (generation) of ROS
2) Confidence 0.76 Published 2005 Journal Anticancer Res. Section Abstract Doc Link 16309195 Disease Relevance 0.43 Pain Relevance 0.11
While these glial responses are beneficial to neurons, the continuous or repeated activation of astrocytes and microglia under conditions of chronic inflammatory stresses can lead to the increased production of ROS/RNS and other neurotoxic mediators, which can lead to severe neuronal damage (Banati et al., 1993; Banati and Graeber, 1994; Aloisi, 2001; Streit, 2002).
Gene_expression (production) of ROS in astrocytes associated with stress and inflammation
3) Confidence 0.71 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.68 Pain Relevance 0.33
Because ROS production is very common and the human body has an abundant capacity for producing anti-oxidants, it is difficult to obtain statistical differences in trials designed to evaluate an anti-oxidative drug.
Gene_expression (production) of ROS in body
4) Confidence 0.68 Published 2009 Journal Adv. Drug Deliv. Rev. Section Abstract Doc Link 19306902 Disease Relevance 0.19 Pain Relevance 0.15
The NSAIDs and short-chain fatty acids under study all possess a carboxyl group, and this carboxyl group is essential for salicylic acid's ability to increase ROS production.
Gene_expression (production) of ROS associated with cinod
5) Confidence 0.68 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9540818 Disease Relevance 0.52 Pain Relevance 0.56
Along with ROS, VEGF, and a large number of mature and immature CD31/vWF positive blood vessels were present in the adhesion tissue.
Gene_expression (present) of ROS in blood vessels associated with adhesions
6) Confidence 0.66 Published 2004 Journal World J Surg Section Abstract Doc Link 14961185 Disease Relevance 1.38 Pain Relevance 0.05
Large doses of acetaminophen (APAP) could cause oxidative stress and tissue damage through production of reactive oxygen/nitrogen (ROS/RNS) species and quinone metabolites of APAP.
Gene_expression (production) of ROS associated with stress and paracetamol
7) Confidence 0.65 Published 2004 Journal Exp. Mol. Med. Section Abstract Doc Link 15031674 Disease Relevance 0.38 Pain Relevance 0.60
In sharp contrast, normal keratinocytes did not show increases in ROS levels and were not killed.
Gene_expression (levels) of ROS in keratinocytes
8) Confidence 0.64 Published 2009 Journal J Drugs Dermatol Section Body Doc Link 19180893 Disease Relevance 0.12 Pain Relevance 0
Our results demonstrate a novel mechanism of sulindac-induced apoptosis in human MM cells, namely, accumulation of p53, Bax, and Bak in mitochondria mediated by p38 MAPK activation downstream of ROS production.
Gene_expression (production) of ROS associated with multiple myeloma and apoptosis
9) Confidence 0.63 Published 2007 Journal Apoptosis Section Abstract Doc Link 17136320 Disease Relevance 1.10 Pain Relevance 0
Bcl-2 cleavage and down-regulation of the inhibitor of apoptosis proteins (IAPs) family including cIAP-1/2, XIAP, and survivin, occurred downstream of ROS production during sulindac-induced apoptosis.
Gene_expression (production) of ROS in cleavage associated with apoptosis
10) Confidence 0.63 Published 2007 Journal Apoptosis Section Abstract Doc Link 17136320 Disease Relevance 1.30 Pain Relevance 0.07
We further studied the effects of Lido on the priming of canine granulocyte CD11b expression and ROS production by recombinant canine granulocyte macrophage colony stimulating factor (rcGM-CSF).
Gene_expression (production) of ROS in granulocyte
11) Confidence 0.63 Published 2010 Journal J. Vet. Med. Sci. Section Abstract Doc Link 19940395 Disease Relevance 0.08 Pain Relevance 0.23
Thus, we studied the effects of Lido on canine granulocyte CD11b expression and ROS production.
Gene_expression (production) of ROS in granulocyte
12) Confidence 0.63 Published 2010 Journal J. Vet. Med. Sci. Section Abstract Doc Link 19940395 Disease Relevance 0.09 Pain Relevance 0.24
ROS production was assessed by the peak time (PT) of ROS production and area under the luminol reaction curve (AUC), which represents total ROS production quantity against opsonized zymosan stimuli.
Gene_expression (production) of ROS
13) Confidence 0.63 Published 2010 Journal J. Vet. Med. Sci. Section Abstract Doc Link 19940395 Disease Relevance 0.13 Pain Relevance 0.20
In conclusion, Lido suppressed granulocyte adhesion to the endothelium and antiseptic capability by suppressing CD11b expression and/or ROS production.
Gene_expression (production) of ROS in granulocyte associated with adhesions
14) Confidence 0.63 Published 2010 Journal J. Vet. Med. Sci. Section Abstract Doc Link 19940395 Disease Relevance 0.10 Pain Relevance 0.17
ROS production was assessed by the peak time (PT) of ROS production and area under the luminol reaction curve (AUC), which represents total ROS production quantity against opsonized zymosan stimuli.
Gene_expression (production) of ROS
15) Confidence 0.63 Published 2010 Journal J. Vet. Med. Sci. Section Abstract Doc Link 19940395 Disease Relevance 0.13 Pain Relevance 0.20
Consistent with the higher ROS production and selective vulnerability of hippocampal CA1, neurons in this region exhibit lower expression of Ucp2 compared with those in CA3 (Richard et al., 2001).


Gene_expression (production) of ROS in neurons
16) Confidence 0.62 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.88 Pain Relevance 0.28
This mitochondrial inner membrane protein can protect neurons from OS by reducing ROS production through the uncoupling of oxidative phosphorylation and ATP synthesis (Horvath et al., 2003).
Gene_expression (production) of ROS in neurons associated with stress
17) Confidence 0.62 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 1.02 Pain Relevance 0.23
In both populations of dopaminergic neurons, the auto-oxidation of dopamine itself and its metabolites can lead to the production of ROS, which is worsened by abundant content of iron and copper in this region (Olney et al., 1990; Jenner et al., 1992).
Gene_expression (production) of ROS in dopaminergic neurons associated with dopamine
18) Confidence 0.62 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 1.03 Pain Relevance 0.33
As indicated previously, the superoxide and hydrogen peroxide generated by the mitochondria can react further to produce other ROS, such as hydroxyl radical and peroxynitrite, thus accounting for the close relationship between mitochondrial activity and cellular OS (Cadenas and Davies, 2000; Balaban et al., 2005).
Gene_expression (produce) of ROS associated with stress
19) Confidence 0.62 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.17 Pain Relevance 0.20
Increased ROS production leads to tissue damage associated with inflammation.
Gene_expression (production) of ROS associated with inflammation
20) Confidence 0.61 Published 2008 Journal Iran J Allergy Asthma Immunol Section Abstract Doc Link 19052348 Disease Relevance 1.46 Pain Relevance 0.43

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