INT69441

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Context Info
Confidence 0.50
First Reported 1997
Last Reported 2011
Negated 5
Speculated 7
Reported most in Body
Documents 38
Total Number 45
Disease Relevance 26.78
Pain Relevance 6.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) plasma membrane (ROS1)
Anatomy Link Frequency
granulocyte 4
neutrophils 4
macrophages 2
hepatocytes 2
colon 2
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 876 100.00 Very High Very High Very High
cytokine 62 100.00 Very High Very High Very High
cINOD 17 100.00 Very High Very High Very High
lidocaine 10 100.00 Very High Very High Very High
nociceptor 2 100.00 Very High Very High Very High
COX2 1 100.00 Very High Very High Very High
Fibrositis 58 99.84 Very High Very High Very High
methotrexate 5 99.72 Very High Very High Very High
Glutamate 40 98.92 Very High Very High Very High
adenocard 64 98.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 29 100.00 Very High Very High Very High
Mycobacterial Infection 282 99.84 Very High Very High Very High
Sleep Disorders 69 99.84 Very High Very High Very High
Death 109 99.80 Very High Very High Very High
Repression 9 99.68 Very High Very High Very High
Skin Cancer 14 99.56 Very High Very High Very High
Aging 92 99.42 Very High Very High Very High
Stress 406 99.24 Very High Very High Very High
Coronary Artery Disease 53 99.14 Very High Very High Very High
Apoptosis 310 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we studied the effects of Lido on canine granulocyte CD11b expression and ROS production.
Regulation (effects) of Gene_expression (production) of ROS in granulocyte
1) Confidence 0.50 Published 2010 Journal J. Vet. Med. Sci. Section Abstract Doc Link 19940395 Disease Relevance 0.09 Pain Relevance 0.25
In this study, we examined the effects of platycodon D on the production of reactive oxygen species (ROS) and evaluated the association of these effects with apoptotic tumor cell death using a human leukemic U937 cell line.
Spec (examined) Regulation (effects) of Gene_expression (production) of ROS associated with cancer, apoptosis and death
2) Confidence 0.39 Published 2009 Journal Biomed. Pharmacother. Section Abstract Doc Link 18804340 Disease Relevance 0.79 Pain Relevance 0.05
Impact of central and peripheral TRPV1 and ROS levels on proinflammatory mediators and nociceptive behavior.
Regulation (Impact) of Gene_expression (levels) of ROS associated with nociception and cox2
3) Confidence 0.37 Published 2010 Journal Mol Pain Section Title Doc Link 20691059 Disease Relevance 0.18 Pain Relevance 0.33
CONCLUSION: Increased levels of ROS appear to be important in the selective killing of cancer cells in the presence of sulindac and oxidizing agents.
Regulation (important) of Gene_expression (levels) of ROS
4) Confidence 0.37 Published 2009 Journal J Drugs Dermatol Section Body Doc Link 19180893 Disease Relevance 0 Pain Relevance 0
We further studied the effects of Lido on the priming of canine granulocyte CD11b expression and ROS production by recombinant canine granulocyte macrophage colony stimulating factor (rcGM-CSF).
Regulation (effects) of Gene_expression (production) of ROS in granulocyte
5) Confidence 0.37 Published 2010 Journal J. Vet. Med. Sci. Section Abstract Doc Link 19940395 Disease Relevance 0.09 Pain Relevance 0.24
Modulation of cytokine synthesis and ROS production may contribute to the therapeutic effects of the anti-arthritic agent, methotrexate.
Regulation (Modulation) of Gene_expression (production) of ROS associated with methotrexate, arthritis and cytokine
6) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2924298 Disease Relevance 0.57 Pain Relevance 0.69
As with diesel exhaust particle exposure, we believe that the production of ROS by the ultrafine particle systems is responsible for this decrease in IL-10 and VEGF secretion, but further investigation, is required to determine and clarify this mechanism.
Spec (investigation) Regulation (responsible) of Spec (investigation) Gene_expression (production) of ROS
7) Confidence 0.27 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2676242 Disease Relevance 0.67 Pain Relevance 0.32
This ubiquitously expressed protein is a plausible negative regulator of ROS production, since it dissipates the inner mitochondrial membrane electrochemical gradient that drives ATP synthesis and uncouples respiration from oxidative phosphorylation [18].
Regulation (regulator) of Gene_expression (production) of ROS
8) Confidence 0.27 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 1.00 Pain Relevance 0
For example, as outlined above, aberrant glutamate neurotransmission can lead to calcium dysregulation, altered metabolic states, abnormal generation of ROS/RNS and therefore OS.
Regulation (altered) of Gene_expression (generation) of ROS associated with stress and glutamate
9) Confidence 0.25 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 1.23 Pain Relevance 0.16
We investigated the effect of local anaesthetics (lidocaine, mepivacaine and bupivacaine) on ROS production by neutrophils using an in vitro system.
Spec (investigated) Regulation (effect) of Gene_expression (production) of ROS in neutrophils associated with lidocaine
10) Confidence 0.24 Published 1997 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 9150783 Disease Relevance 0.20 Pain Relevance 0.20
However, these local anaesthetics at clinically relevant blood concentrations had no effect on the levels of ROS.
Neg (no) Regulation (effect) of Gene_expression (levels) of ROS in blood
11) Confidence 0.24 Published 1997 Journal Acta Anaesthesiol Scand Section Body Doc Link 9150783 Disease Relevance 0 Pain Relevance 0
The role of ROS production in the regulation of CD36 expression induced by TNF?
Regulation (role) of Gene_expression (production) of ROS
12) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.09 Pain Relevance 0
We discuss pathogenic factors that can influence clinical expression, especially ATP shortage and reactive oxygen radicals (ROS) excess.
Regulation (influence) of Gene_expression (expression) of ROS
13) Confidence 0.21 Published 2009 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 20225024 Disease Relevance 0.27 Pain Relevance 0.09
Further to examine the role of ROS generation in FM, BMCs of one representative patient were incubated with three antioxidants, CoQ10, ?
Spec (examine) Regulation (role) of Spec (examine) Gene_expression (generation) of ROS associated with fibrositis
14) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875645 Disease Relevance 1.12 Pain Relevance 0.42
Culture supernatant preparations, the prime source of the 87-kDa cytotoxin, from both H. pylori strains 60190 and 60190-v1 were extracted under identical conditions to determine the role of 87-kDa cytotoxin on the enhanced production of ROS and DNA fragmentation.
Spec (determine) Regulation (role) of Gene_expression (production) of ROS associated with sprains and strains
15) Confidence 0.19 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12064819 Disease Relevance 0.57 Pain Relevance 0
The effects of culture supernatant preparations from H. pylori strains 60190 and 60190-v1 on the enhanced production of ROS and increased DNA fragmentation in mucosal cells were also investigated.
Spec (investigated) Regulation (effects) of Gene_expression (production) of ROS associated with sprains and strains
16) Confidence 0.19 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12064819 Disease Relevance 0.59 Pain Relevance 0
These results suggest that ROS production is not involved in the repression of CD36 induced by TNF?.
Neg (not) Regulation (involved) of Gene_expression (production) of ROS associated with repression
17) Confidence 0.17 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.29 Pain Relevance 0.21
The role of ROS production in the regulation of CD36 expression induced by TNF?
Regulation (role) of Gene_expression (production) of ROS
18) Confidence 0.17 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.09 Pain Relevance 0
Cells contain antioxidant enzymes to regulate steady state levels of ROS produced by products of metabolism.
Regulation (regulate) of Gene_expression (produced) of ROS
19) Confidence 0.15 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12649190 Disease Relevance 0.58 Pain Relevance 0.09
The influence of NSAIDs and butyrate on ROS generation and death ligand sensitivity may be relevant to their ability to suppress colon carcinogenesis.
Regulation (influence) of Gene_expression (generation) of ROS in colon associated with cinod and death
20) Confidence 0.15 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9990295 Disease Relevance 0.76 Pain Relevance 0.25

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