INT69460

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Context Info
Confidence 0.49
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 18
Disease Relevance 6.54
Pain Relevance 8.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm2) plasma membrane (Grm2) intracellular (Grm2)
signal transducer activity (Grm2)
Anatomy Link Frequency
neurons 2
DRG 2
excitatory neurons 1
neuronal 1
outflow 1
Grm2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 64 100.00 Very High Very High Very High
dorsal root ganglion 8 100.00 Very High Very High Very High
analgesia 53 99.90 Very High Very High Very High
tetrodotoxin 6 99.84 Very High Very High Very High
Glutamate 73 99.28 Very High Very High Very High
antinociception 6 99.20 Very High Very High Very High
cytokine 12 98.96 Very High Very High Very High
Analgesic 31 98.80 Very High Very High Very High
Dopamine 124 98.52 Very High Very High Very High
Neurotransmitter 14 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 9 100.00 Very High Very High Very High
Disease 100 99.16 Very High Very High Very High
Toxicity 36 99.16 Very High Very High Very High
Pain 46 98.12 Very High Very High Very High
Nervous System Injury 12 97.04 Very High Very High Very High
Nociception 3 94.48 High High
INFLAMMATION 68 92.56 High High
Targeted Disruption 34 85.60 High High
Anxiety Disorder 436 85.28 High High
Neuropathic Pain 35 85.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rat cortical slices, AIDA antagonized the stimulatory (mGluR1-mediated) effect of (1S,3R)-ACPD on the depolarization-induced outflow of D-[3H]aspartate, disclosing an inhibitory effect ascribable to (1S,3R)-ACPD activating mGluR2 and/or mGluR4.
Positive_regulation (activating) of mGluR2 in outflow
1) Confidence 0.49 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9152378 Disease Relevance 0.09 Pain Relevance 0.38
Activation of group II metabotropic glutamate receptors (mGlu2 and mGlu3) induces antinociception in several pain models in rodents [1-5].
Positive_regulation (Activation) of mGlu2 associated with pain, antinociception and glutamate receptor
2) Confidence 0.17 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0.31 Pain Relevance 0.67
Given that in addition to its role in fatty acid metabolism LAC also behaves as a donor of acetyl groups for amino acids and proteins [24], we examined whether LAC-induced mGlu2 upregulation is mediated by the NF-?
Spec (whether) Positive_regulation (upregulation) of mGlu2
3) Confidence 0.12 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0 Pain Relevance 0
B suppresses the transient increase in mGlu2 mRNA induced by LAC in DRG cultures
Positive_regulation (increase) of mGlu2 mRNA
4) Confidence 0.11 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0 Pain Relevance 0
B-mediated mGlu2 upregulation might be responsible for the analgesic effects of LAC against peripheral nerve injury and in acute thermal pain [10].
Positive_regulation (upregulation) of mGlu2 in peripheral nerve associated with pain, nervous system injury, analgesic and peripheral nerve injury
5) Confidence 0.11 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 1.04 Pain Relevance 1.31
B transcription factors might induce analgesia via upregulation of mGlu2 in DRG neurons.



Positive_regulation (upregulation) of mGlu2 in neurons associated with analgesia
6) Confidence 0.10 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1550235 Disease Relevance 0.09 Pain Relevance 0.30
B transcription factors might induce analgesia via upregulation of mGlu2 in DRG neurons.


Positive_regulation (upregulation) of mGlu2 in neurons associated with analgesia
7) Confidence 0.10 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0.24 Pain Relevance 0.54
These observations strongly suggesting the beneficial effects of 2R,4R-APDC effects are mediated through selective activation of mGluR2/3 in vivo (Vernon et al., unpublished observations).
Positive_regulation (activation) of mGluR2
8) Confidence 0.02 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951138 Disease Relevance 0.31 Pain Relevance 0.15
However, we fully acknowledge that the significance of these data should be interpreted with the caveat that we have utilised a dual mGluR2/3 agonists and thus any beneficial effects are likely to be influenced by confounding effects due to activation of mGluR2 in vivo [15].
Positive_regulation (activation) of mGluR2 associated with agonist
9) Confidence 0.02 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951138 Disease Relevance 0.25 Pain Relevance 0.27
Further, activation of mGluR2/3 stimulates the production and release of neurotrophic factors from glial cells in vitro [12, 13] and in vivo [14–16].
Positive_regulation (activation) of mGluR2 in glial cells
10) Confidence 0.02 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951138 Disease Relevance 0.52 Pain Relevance 0.37
Importantly, excessive neuronal activity leading to glutamate spillover seems to be required for activation of mGluR2, suggesting that its function may be to protect against pathological bouts of glutamatergic hyperexcitability [144].
Positive_regulation (activation) of mGluR2 in neuronal associated with glutamate and hyperexcitability
11) Confidence 0.02 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.52 Pain Relevance 0.52
Thus, activation of mGluR2 on excitatory neurons negatively modulates neurotransmitter release.
Positive_regulation (activation) of mGluR2 in excitatory neurons associated with neurotransmitter
12) Confidence 0.02 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.62 Pain Relevance 0.48
Conversely, activation of microglial mGluR2 enhances microglial toxicity in vitro [42, 43].
Positive_regulation (activation) of mGluR2 associated with toxicity
13) Confidence 0.02 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951138 Disease Relevance 0.21 Pain Relevance 0.17
Indeed, our own data demonstrate that this may be observed following activation of nigral mGluR2/3 in isolation.
Positive_regulation (activation) of mGluR2
14) Confidence 0.02 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951138 Disease Relevance 0.24 Pain Relevance 0.37
Notably again, this appears predominantly due to the activation of mGluR2 [38].
Positive_regulation (activation) of mGluR2
15) Confidence 0.02 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951138 Disease Relevance 0.26 Pain Relevance 0.23
Here we studied the effects of group II mGluR activation on TTX-resistant sodium currents in cultured mouse dorsal root ganglion (DRG) neurons.
Positive_regulation (activation) of mGluR in DRG associated with ganglion cysts, dorsal root ganglion and tetrodotoxin
16) Confidence 0.00 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15003274 Disease Relevance 0.46 Pain Relevance 0.74
Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes.
Positive_regulation (Induction) of mGlu2 in DRG associated with dorsal root ganglion
17) Confidence 0.00 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19255242 Disease Relevance 0.65 Pain Relevance 0.90
Induction of mGlu2 receptors is mediated by acetylation mechanisms that involve transcription factors of the nuclear factor (NF)-kappaB family.
Positive_regulation (Induction) of mGlu2
18) Confidence 0.00 Published 2007 Journal CNS Drugs Section Abstract Doc Link 17696591 Disease Relevance 0.72 Pain Relevance 0.80

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