INT69471

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Context Info
Confidence 0.73
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.07
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
3A5 1
CYP3A (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 10 99.84 Very High Very High Very High
rapifen 10 99.62 Very High Very High Very High
Bioavailability 10 98.58 Very High Very High Very High
methadone 8 96.96 Very High Very High Very High
antiepileptic Drug 2 91.12 High High
carbamazepine 3 89.72 High High
withdrawal 3 75.92 Quite High
antagonist 26 50.00 Quite Low
Opioid 2 43.12 Quite Low
alcohol 5 35.40 Quite Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 8 71.76 Quite High
Vomiting 117 50.00 Quite Low
Neutropenia 8 5.00 Very Low Very Low Very Low
Post-operative Nausea 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Fatigue 4 5.00 Very Low Very Low Very Low
Arrhythmia Under Development 4 5.00 Very Low Very Low Very Low
Alopecia 3 5.00 Very Low Very Low Very Low
Sleep Disorders 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to its pharmacokinetics humans, methadone has a short elimination half-life, rapid clearance, and low oral bioavailability in dogs and the extent of absorption is not affected by inhibition of CYP3A, p-gp, and gastric acid secretion.
Localization (secretion) of CYP3A associated with methadone and bioavailability
1) Confidence 0.73 Published 2005 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 16207309 Disease Relevance 0 Pain Relevance 0.68
Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation.
Localization (Contribution) of CYP3A associated with paracetamol
2) Confidence 0.58 Published 2000 Journal Clin. Pharmacol. Ther. Section Title Doc Link 10741631 Disease Relevance 0 Pain Relevance 0.28
Alfentanil is one of the few CYP3A substrates that is metabolized in vitro as avidly by both CYP3A4 and 3A5.
Localization (metabolized) of CYP3A in 3A5 associated with rapifen
3) Confidence 0.50 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15557344 Disease Relevance 0 Pain Relevance 0.24
CYP2E1 and CYP2B increased, whereas CYP3A decreased and the others did not change.
Localization (decreased) of CYP3A
4) Confidence 0.44 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9152386 Disease Relevance 0 Pain Relevance 0.35
Thus, appropriate therapeutic effects can hardly be obtained unless the doses are increased significantly, since plasma concentrations are not elevated in patients receiving these drugs which are metabolized by CYP3A.
Localization (metabolized) of CYP3A in plasma
5) Confidence 0.39 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2584094 Disease Relevance 0.07 Pain Relevance 0.13
Oral contraceptives are also metabolized by CYP3A-enzymes.
Localization (metabolized) of CYP3A
6) Confidence 0.11 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697542 Disease Relevance 0 Pain Relevance 0

General Comments

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