INT69480

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Context Info
Confidence 0.89
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GBA) hydrolase activity, acting on glycosyl bonds (GBA) cell death (GBA)
carbohydrate metabolic process (GBA) lipid metabolic process (GBA)
Anatomy Link Frequency
cleavage 1
mononuclear phagocyte 1
GBA (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 1 25.00 Low Low
Pain 4 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gauchers Disease 86 98.14 Very High Very High Very High
Disease 25 47.88 Quite Low
Neurologic Manifestations 8 8.00 Low Low
Infection 8 5.00 Very Low Very Low Very Low
Rare Diseases 7 5.00 Very Low Very Low Very Low
Aseptic Necrosis Of Bone 5 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Anaemia 3 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gaucher disease most obviously affects cells of mononuclear phagocyte lineage in which prominent storage of undegraded lipids occurs (see Figure 1); mutations in the gene (GBA1) which encodes human ?
Protein_catabolism (undegraded) of GBA1 in mononuclear phagocyte associated with gauchers disease
1) Confidence 0.89 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC3010821 Disease Relevance 0.38 Pain Relevance 0
In both cases, cleavage of the glucuronide by human beta-glucuronidase (beta-Gluc) would release the parent compound, thereby modifying drug disposition.
Protein_catabolism (cleavage) of beta-Gluc in cleavage
2) Confidence 0.74 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9152401 Disease Relevance 0 Pain Relevance 0

General Comments

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