INT69481

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Context Info
Confidence 0.28
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.38
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcna1) transmembrane transport (Kcna1)
Kcna1 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 38 98.98 Very High Very High Very High
hyperexcitability 2 93.28 High High
Analgesic 6 89.88 High High
Neuropathic pain 2 89.20 High High
antinociception 6 88.64 High High
Morphine 10 87.12 High High
analgesia 4 86.08 High High
Intracerebroventricular 4 83.32 Quite High
Neuronal excitability 4 81.40 Quite High
Hippocampus 4 71.40 Quite High
Disease Link Frequency Relevance Heat
Convulsion 2 96.60 Very High Very High Very High
Toxicity 2 95.72 Very High Very High Very High
Demyelinating Disease 20 55.60 Quite High
Congenital Anomalies 8 17.84 Low Low
Schizophrenia 6 5.00 Very Low Very Low Very Low
Neurological Disease 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Adrenoleukodystrophy 2 5.00 Very Low Very Low Very Low
Lipidosis 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compounds were found to act by several mechanisms to prevent Kvbeta1 inactivation of Kv1.1 channels, including enhancement of Ca(2+) release/influx and by direct mechanisms.
Negative_regulation (inactivation) of Kv1
1) Confidence 0.28 Published 2008 Journal Bioorg. Med. Chem. Section Abstract Doc Link 18226531 Disease Relevance 0.10 Pain Relevance 0.23
It is likely that these disinactivators act directly on the Kvbeta1 N-terminus or its receptor site on Kv1.1, thus preventing it from blocking Kv1.1 channels.
Negative_regulation (blocking) of Kv1
2) Confidence 0.24 Published 2008 Journal Bioorg. Med. Chem. Section Abstract Doc Link 18226531 Disease Relevance 0.08 Pain Relevance 0.23
The Kv channel blocker dendrotoxin-1 (DTX) is a specific inhibitor of the juxtaparanodal channels Kv1.1 and Kv1.2 and does not perturb CAP latencies or shape in wild-type mice (Fig. 3 A, top).
Negative_regulation (inhibitor) of Kv1 associated with potassium channel
3) Confidence 0.02 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592840 Disease Relevance 0.06 Pain Relevance 0.12
The Kv channel blocker dendrotoxin-1 (DTX) is a specific inhibitor of the juxtaparanodal channels Kv1.1 and Kv1.2 and does not perturb CAP latencies or shape in wild-type mice (Fig. 3 A, top).
Negative_regulation (inhibitor) of Kv1 associated with potassium channel
4) Confidence 0.02 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592840 Disease Relevance 0.06 Pain Relevance 0.12
Quantitative reverse transcription-polymerase chain reaction analysis demonstrated that a decrease in mKv1.1 mRNA levels occurred only in the aODN-treated group, being absent in all control groups.
Negative_regulation (decrease) of mKv1
5) Confidence 0.01 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9152404 Disease Relevance 0.10 Pain Relevance 1.04
Inactivation of the Kv1.1 gene, which codes for a member of the Shaker-like potassium channels by an antisense oligodeoxyribonucleotide (aODN), was carried out in mice.
Negative_regulation (Inactivation) of Kv1.1 gene associated with potassium channel
6) Confidence 0.01 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9152404 Disease Relevance 0 Pain Relevance 0.59

General Comments

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