INT69482

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Context Info
Confidence 0.32
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.27
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcna1) transmembrane transport (Kcna1)
Kcna1 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 5 98.16 Very High Very High Very High
analgesia 2 86.08 High High
Morphine 5 84.40 Quite High
Neuronal excitability 4 81.40 Quite High
antinociception 3 75.00 Quite High
Intracerebroventricular 2 74.08 Quite High
Hippocampus 3 71.40 Quite High
hyperexcitability 2 64.08 Quite High
Neuropathic pain 2 60.00 Quite High
Spinal cord 2 56.08 Quite High
Disease Link Frequency Relevance Heat
Convulsion 2 96.60 Very High Very High Very High
Ataxia 21 76.56 Quite High
Toxicity 1 28.88 Quite Low
Depression 1 10.40 Low Low
Camurati-engelmann Disease 2 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compounds were found to act by several mechanisms to prevent Kvbeta1 inactivation of Kv1.1 channels, including enhancement of Ca(2+) release/influx and by direct mechanisms.
Positive_regulation (enhancement) of Kv1
1) Confidence 0.32 Published 2008 Journal Bioorg. Med. Chem. Section Abstract Doc Link 18226531 Disease Relevance 0.10 Pain Relevance 0.24
Compounds were found to act by several mechanisms to prevent Kvbeta1 inactivation of Kv1.1 channels, including enhancement of Ca(2+) release/influx and by direct mechanisms.
Positive_regulation (inactivation) of Kv1
2) Confidence 0.32 Published 2008 Journal Bioorg. Med. Chem. Section Abstract Doc Link 18226531 Disease Relevance 0.10 Pain Relevance 0.23
Maximal activation of BK channels (alias maxiK, KCNMA1, KCa1.1 or slowpoke) requires both membrane depolarization and increased intracellular Ca2+[4], [5].
Positive_regulation (activation) of KCa1
3) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776494 Disease Relevance 0.08 Pain Relevance 0
Inactivation of the Kv1.1 gene, which codes for a member of the Shaker-like potassium channels by an antisense oligodeoxyribonucleotide (aODN), was carried out in mice.
Positive_regulation (Inactivation) of Kv1.1 gene associated with potassium channel
4) Confidence 0.01 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9152404 Disease Relevance 0 Pain Relevance 0.59

General Comments

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