INT69483

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Context Info
Confidence 0.72
First Reported 1997
Last Reported 2011
Negated 1
Speculated 3
Reported most in Abstract
Documents 45
Total Number 48
Disease Relevance 7.31
Pain Relevance 30.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
Anatomy Link Frequency
brain 3
lymphocytes 2
T-lymphocytes 2
macrophages 1
SH-SY5Y 1
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 199 100.00 Very High Very High Very High
mu opioid receptor 74 100.00 Very High Very High Very High
Opioid 69 100.00 Very High Very High Very High
opiate 49 100.00 Very High Very High Very High
Morphine 44 100.00 Very High Very High Very High
Codeine 11 100.00 Very High Very High Very High
Opioid receptor 1 9 100.00 Very High Very High Very High
orphanin 8 100.00 Very High Very High Very High
Serotonin 2 100.00 Very High Very High Very High
agonist 10 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Drug Dependence 6 99.76 Very High Very High Very High
Necrosis 10 99.68 Very High Very High Very High
Neuroblastoma 13 99.52 Very High Very High Very High
Cancer 10 99.50 Very High Very High Very High
Urological Neuroanatomy 4 99.16 Very High Very High Very High
Pain 7 99.00 Very High Very High Very High
INFLAMMATION 19 98.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 96.08 Very High Very High Very High
Nociception 2 95.48 Very High Very High Very High
Depression 1 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the 3' noncoding region of the human OPRM1 gene had not yet been characterized, in the present study we conducted 3'-rapid amplification of cDNA ends (3'RACE)-PCR and identified the 3' end of the human MOR-1 mRNA, the most abundant transcript among OPRM1 gene transcripts.
Transcription (transcript) of MOR-1 associated with opioid receptor
1) Confidence 0.72 Published 2005 Journal Gene Section Abstract Doc Link 16122888 Disease Relevance 0 Pain Relevance 0.50
As the 3' noncoding region of the human OPRM1 gene had not yet been characterized, in the present study we conducted 3'-rapid amplification of cDNA ends (3'RACE)-PCR and identified the 3' end of the human MOR-1 mRNA, the most abundant transcript among OPRM1 gene transcripts.
Transcription (transcript) of OPRM1 gene associated with opioid receptor
2) Confidence 0.72 Published 2005 Journal Gene Section Abstract Doc Link 16122888 Disease Relevance 0 Pain Relevance 0.49
We have measured allele-specific mRNA expression of OPRM1 in human autopsy brain tissues, using A118G as a marker.
Transcription (expression) of OPRM1 in brain
3) Confidence 0.69 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16046395 Disease Relevance 0.18 Pain Relevance 0.38
The role of transcription factors Sp1 and YY1 in proximal promoter region in initiation of transcription of the mu opioid receptor gene in human lymphocytes.
Transcription (transcription) of mu opioid receptor gene in lymphocytes associated with mu opioid receptor
4) Confidence 0.68 Published 2008 Journal J. Cell. Biochem. Section Title Doc Link 17990281 Disease Relevance 0 Pain Relevance 0.36
Thus, we conclude that the cooperative interaction of Sp1 and YY1 transcription factors is the critical event triggering the initiation of transcription of the MOR gene in lymphocytes, and this finding will be helpful to understand the pharmacological effect of morphine on lymphocytes.
Transcription (transcription) of MOR gene in lymphocytes associated with mu opioid receptor and morphine
5) Confidence 0.68 Published 2008 Journal J. Cell. Biochem. Section Abstract Doc Link 17990281 Disease Relevance 0 Pain Relevance 0.41
The MOR gene is tightly regulated at the level of transcription, and potential polymorphisms in its 5' regulatory region can cause individual variation in MOR gene expression, nociception, and opiate responses.
Transcription (transcription) of MOR gene associated with nociception, mu opioid receptor and opiate
6) Confidence 0.60 Published 2001 Journal DNA Cell Biol. Section Abstract Doc Link 11506703 Disease Relevance 0.29 Pain Relevance 0.61
To study the 5' regulatory region of the human MOR gene (hMOR), we further investigated our previous finding of two regulatory regions and have localized a 40-bp positive cis-acting element and a 35-bp negative cis-acting element that regulate hMOR transcription in SK-N-SH cells.
Transcription (transcription) of hMOR in SK-N-SH associated with mu opioid receptor
7) Confidence 0.60 Published 2001 Journal DNA Cell Biol. Section Abstract Doc Link 11506703 Disease Relevance 0.25 Pain Relevance 0.54
Binding of gp120 to macrophages stimulates the cells to release various pro-inflammatory cytokines, including TNF-alpha, which has been shown to regulate transcription of the MOR gene.
Transcription (transcription) of MOR in macrophages associated with inflammation, mu opioid receptor and cytokine
8) Confidence 0.59 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16846840 Disease Relevance 0.69 Pain Relevance 0.66
In addition, STAT6 induces expression of the transcription factor GATA3, which also contributes to mu-opioid receptor gene transcription.
Transcription (transcription) of mu-opioid receptor associated with opioid receptor
9) Confidence 0.58 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16434616 Disease Relevance 0 Pain Relevance 1.03
Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells.
Transcription (transcription) of mu-opioid receptor in T cells associated with cannabinoid receptor, agonist and opioid receptor
10) Confidence 0.58 Published 2006 Journal Mol. Pharmacol. Section Title Doc Link 16434616 Disease Relevance 0 Pain Relevance 0.77
We report that activation of the peripheral cannabinoid receptor type 2 leads to a de novo induction of mu-opioid receptor transcription in Jurkat E6.1 cells.
Transcription (transcription) of mu-opioid receptor associated with cannabinoid receptor and opioid receptor
11) Confidence 0.58 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16434616 Disease Relevance 0 Pain Relevance 0.73
Analysis of the distribution of mRNA encoding the serotonin (5-hydroxytryptamine) 5-HT(2A) receptor and the mu opioid peptide receptor in rat brain demonstrated their coexpression in neurons in several distinct regions.
Transcription (distribution) of mu opioid peptide receptor in brain associated with opioid and serotonin
12) Confidence 0.57 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18703670 Disease Relevance 0.09 Pain Relevance 0.79
In this paper we show that human epidermal keratinocytes express a mu-opiate receptor on both the mRNA level and the protein level.
Transcription (express) of opiate receptor in keratinocytes associated with opiate
13) Confidence 0.56 Published 1998 Journal J. Invest. Dermatol. Section Abstract Doc Link 9699733 Disease Relevance 0 Pain Relevance 0.52
The correlation between the locations of both mRNA and protein expression in skin indicates that the mu-opiate receptor has not only been transcribed but also has a specific function.
Transcription (transcribed) of opiate receptor in skin associated with opiate
14) Confidence 0.56 Published 1998 Journal J. Invest. Dermatol. Section Abstract Doc Link 9699733 Disease Relevance 0 Pain Relevance 0.70
The MOR gene is highly regulated at the level of transcription.
Transcription (transcription) of MOR gene associated with mu opioid receptor
15) Confidence 0.56 Published 2001 Journal Gene Section Abstract Doc Link 11675004 Disease Relevance 0 Pain Relevance 0.58
This study demonstrated the expression of mu-opiate receptor mRNA in cultured epidermal melanocytes, as well as mRNA for pro-opiomelanocortin.
Transcription (expression) of mu-opiate receptor in melanocytes associated with opiate
16) Confidence 0.54 Published 2003 Journal J. Invest. Dermatol. Section Abstract Doc Link 12787137 Disease Relevance 0 Pain Relevance 0.57
As the 3' noncoding region of the human OPRM1 gene had not yet been characterized, in the present study we conducted 3'-rapid amplification of cDNA ends (3'RACE)-PCR and identified the 3' end of the human MOR-1 mRNA, the most abundant transcript among OPRM1 gene transcripts.
Transcription (transcripts) of OPRM1 gene associated with opioid receptor
17) Confidence 0.53 Published 2005 Journal Gene Section Abstract Doc Link 16122888 Disease Relevance 0 Pain Relevance 0.49
Using primer sets designed to span the entire open reading frame of the human brain mu opioid receptor (MOR), we found that microglial cells constitutively expressed MOR mRNA.
Transcription (expressed) of MOR in microglial cells associated with mu opioid receptor
18) Confidence 0.53 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9152411 Disease Relevance 0.09 Pain Relevance 0.59
MOR1 receptor mRNA expression in human brains of drug-related fatalities-a real-time PCR quantification.
Transcription (expression) of MOR1 in brains
19) Confidence 0.53 Published 2004 Journal Forensic Sci. Int. Section Title Doc Link 15013161 Disease Relevance 0.25 Pain Relevance 0.50
Human vascular and cardiac endothelia express mu opiate receptor transcripts.
Transcription (express) of mu opiate receptor in endothelia associated with opioid receptor 1
20) Confidence 0.53 Published 2000 Journal Endothelium Section Title Doc Link 10912912 Disease Relevance 0 Pain Relevance 0.58

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