INT69485

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Context Info
Confidence 0.34
First Reported 1997
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 14
Total Number 18
Disease Relevance 9.99
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Bcl2a1c) cellular_component (Bcl2a1c) biological_process (Bcl2a1c)
Anatomy Link Frequency
blood 2
plasma 2
vein 1
Bcl2a1c (Mus musculus)
Pain Link Frequency Relevance Heat
peripheral neuropathy 7 92.44 High High
Calcium channel 8 56.40 Quite High
alcohol 7 55.52 Quite High
Angina 1 46.00 Quite Low
Bile 49 43.16 Quite Low
corticosteroid 6 27.88 Quite Low
vaginimus 3 27.16 Quite Low
abdominal pain 3 25.00 Low Low
aspirin 28 5.00 Very Low Very Low Very Low
tolerance 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1230 100.00 Very High Very High Very High
Diabetes Complications 22 99.92 Very High Very High Very High
Coronary Artery Disease 27 93.60 High High
Peripheral Neuropathy 7 92.44 High High
Obesity 43 92.16 High High
Ocular Toxicity (including Many Sub-types) 36 90.96 High High
Renal Disease 51 90.44 High High
Nicotine Addiction 34 90.32 High High
Dyslipidemia /

Combined Dyslipidemia

32 89.92 High High
Hypertension 58 89.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A1C reflects mean blood glucose levels including both fasting and postprandial glucose levels [25] and is not affected by glycemic instability [29].
Neg (not) Regulation (affected) of A1C in blood
1) Confidence 0.34 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2898931 Disease Relevance 0.70 Pain Relevance 0
Fig. 1A shows the changes in A1C level at three month intervals, illustrating that the levels gradually decreased over 12 months.
Regulation (changes) of A1C
2) Confidence 0.22 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2898931 Disease Relevance 0.16 Pain Relevance 0.03
A1C values in the last four consecutive clinic visits were attained from the women's medical records.
Regulation (values) of A1C
3) Confidence 0.19 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494660 Disease Relevance 0.77 Pain Relevance 0.05
Change of A1C over 12 months
Regulation (Change) of A1C
4) Confidence 0.13 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2898931 Disease Relevance 0.16 Pain Relevance 0.03
In a similar vein, physiologic control of some aspects of diabetes (especially achievement of tight control of A1C and LDL) appears to vary importantly across practices with ICCs of 0.046 for A1C below 7% and 0.029 for LDL below 100 mg/dl.
Regulation (control) of A1C in vein associated with diabetes mellitus
5) Confidence 0.10 Published 2006 Journal BMC Med Res Methodol Section Body Doc Link PMC1513389 Disease Relevance 0.10 Pain Relevance 0
Secondary efficacy parameters included mean change in FPG, fructosamine, and C-peptide; mean change in A1C for the sulfonylurea monotherapy and sulfonylurea combination therapy cohorts; percentage of subjects achieving a reduction in FPG ?
Regulation (change) of A1C
6) Confidence 0.07 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494667 Disease Relevance 0.11 Pain Relevance 0
After adjusting for confounding factors that may influence IMT, A1C variability was significantly associated with the progression of IMT (r = 0.222, P = 0.034).
Spec (may) Regulation (influence) of A1C
7) Confidence 0.06 Published 2010 Journal Korean Diabetes Journal Section Abstract Doc Link PMC2898931 Disease Relevance 0.43 Pain Relevance 0
RESULTS—The least squares (LS) mean change in A1C from baseline to week 26 was ?
Regulation (change) of A1C
8) Confidence 0.05 Published 2008 Journal Diabetes Care Section Abstract Doc Link PMC2494667 Disease Relevance 0.60 Pain Relevance 0
This study enrolled adults with type 2 diabetes that was inadequately controlled (A1C 7.5–9.5%, inclusive) on a stable dose of sulfonylurea alone or in combination with additional oral antidiabetes agents for ?
Regulation (enrolled) of A1C associated with diabetes mellitus
9) Confidence 0.05 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494667 Disease Relevance 0.68 Pain Relevance 0.03
The American Diabetes Association (ADA) recommends an A1C target of <7.0% (6), the level at which clinical trials have demonstrated fewer long-term microvascular complications (7).
Regulation (target) of A1C associated with diabetes mellitus
10) Confidence 0.03 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494667 Disease Relevance 1.01 Pain Relevance 0
Because they identify only averages and not whether the person had severe extreme blood glucose readings, A1C/eAG results are of no value in predicting short-term complications of diabetes and thus have no use in evaluating individuals in employment situations.
Neg (no) Regulation (value) of A1C in blood associated with diabetes mellitus
11) Confidence 0.02 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797379 Disease Relevance 0.37 Pain Relevance 0
Efficacy of glycemic control was assessed by changes in glycated hemoglobin A1c (Hb A1c) and 1-hour postprandial plasma glucose (PPG) levels.
Regulation (changes) of A1c in plasma
12) Confidence 0.02 Published 1997 Journal Clin Ther Section Abstract Doc Link 9152567 Disease Relevance 0.53 Pain Relevance 0
Efficacy of glycemic control was assessed by changes in glycated hemoglobin A1c (Hb A1c) and 1-hour postprandial plasma glucose (PPG) levels.
Regulation (changes) of A1c in plasma
13) Confidence 0.02 Published 1997 Journal Clin Ther Section Abstract Doc Link 9152567 Disease Relevance 0.53 Pain Relevance 0
Thus, the lower sensitivity of A1C at the designated cut point may well be offset by the test's greater practicality, and wider application of a more convenient test (A1C) may actually increase the number of diagnoses made.
Regulation (sensitivity) of A1C
14) Confidence 0.01 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 0.66 Pain Relevance 0
In this study, all A1C values were converted to the Diabetes Control and Complication Trial (DCCT) standard values using the following formula: A1C (DCCT) = 0.923 × A1C (MonoS) + 1.345; R2 = 0.998 (15).


Regulation (values) of A1C associated with diabetes mellitus
15) Confidence 0.00 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2551651 Disease Relevance 1.31 Pain Relevance 0
The authors did not report the changes in A1C for the 30 ?
Neg (not) Regulation (changes) of A1C
16) Confidence 0.00 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761191 Disease Relevance 0.52 Pain Relevance 0
A post-hoc analysis of Ratner et al (2002) and Hollander et al (2003b) examined changes in A1C and weight in African American, Hispanic, and Caucasian patients treated with either placebo or pramlinitide 120 ?
Spec (examined) Regulation (changes) of A1C
17) Confidence 0.00 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761191 Disease Relevance 0.51 Pain Relevance 0
At the end of the study, the changes in A1C were as follows: +0.1% for the placebo, ?
Regulation (changes) of A1C
18) Confidence 0.00 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761191 Disease Relevance 0.69 Pain Relevance 0

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