INT69498

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Context Info
Confidence 0.50
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 0.95
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (DRD4) cytoplasm (DRD4) signal transducer activity (DRD4)
DRD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 11 100.00 Very High Very High Very High
Opioid 8 98.64 Very High Very High Very High
drug abuse 6 95.56 Very High Very High Very High
cocaine 2 88.08 High High
Morphine 2 79.44 Quite High
alcohol 3 78.92 Quite High
dopamine receptor 10 74.28 Quite High
addiction 9 38.64 Quite Low
opiate 1 34.64 Quite Low
Nicotine 4 13.16 Low Low
Disease Link Frequency Relevance Heat
Drug Dependence 6 95.56 Very High Very High Very High
Coronary Artery Disease 1 91.72 High High
Alcohol Addiction 3 88.68 High High
Cocaine Dependence 2 88.08 High High
Attention Deficit Hyperactivity Disorder 8 48.56 Quite Low
Nicotine Addiction 13 13.60 Low Low
Opiate Addiction 2 5.00 Very Low Very Low Very Low
Hypoactive Sexual Desire Disorder 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Reprotox - General 3 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is consistent with the dramatic differences in DRD4 VNTR allele frequencies and behavioral patterns found globally such as in the generally polygamous and agonistic Yanomamö Indians of South America (high 7R+ frequencies) and the generally egalitarian !
Positive_regulation (differences) of DRD4 VNTR
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994774 Disease Relevance 0.09 Pain Relevance 0
Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects.
Positive_regulation (Excess) of dopamine D4 receptor associated with dopamine and opioid
2) Confidence 0.46 Published 1997 Journal Mol. Psychiatry Section Title Doc Link 9152990 Disease Relevance 0.43 Pain Relevance 0.65
Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects.
Positive_regulation (Excess) of D4DR associated with dopamine and opioid
3) Confidence 0.46 Published 1997 Journal Mol. Psychiatry Section Title Doc Link 9152990 Disease Relevance 0.43 Pain Relevance 0.65

General Comments

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