INT69499

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Context Info
Confidence 0.36
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 2.56
Pain Relevance 6.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Anatomy Link Frequency
neuronal 3
nerve 2
postsynaptic membrane 1
neurons 1
brain 1
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 21 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 13 100.00 Very High Very High Very High
Clonidine 20 99.98 Very High Very High Very High
nMDA receptor 18 99.80 Very High Very High Very High
Tetrahydrobiopterin 2 99.48 Very High Very High Very High
Somatostatin 18 99.24 Very High Very High Very High
Inflammation 10 99.00 Very High Very High Very High
antidepressant 7 98.84 Very High Very High Very High
Morphine 4 97.28 Very High Very High Very High
Central grey 3 97.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cough 144 99.16 Very High Very High Very High
INFLAMMATION 11 99.00 Very High Very High Very High
Death 3 97.20 Very High Very High Very High
Urological Neuroanatomy 3 97.08 Very High Very High Very High
Depression 1 92.04 High High
Glioma 6 90.72 High High
Ganglion Cysts 1 90.56 High High
Brain Hemorrhage 2 90.00 High High
Increased Venous Pressure Under Development 5 85.68 High High
Acidosis 2 81.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of kyotorphin (L-tyrosyl-L-arginine) ON[3H]NG-nitro-L-arginine binding to neuronal nitric oxide synthase in rat brain.
neuronal nitric oxide synthase Binding (binding) of in brain associated with neuronal nitric oxide synthase
1) Confidence 0.36 Published 1997 Journal Neurochem. Int. Section Title Doc Link 9153002 Disease Relevance 0 Pain Relevance 0.57
Three major populations of nerve terminals innervating the organ can be distinguished: (1) noradrenergic fibres; (2) cholinergic fibres containing vasoactive intestinal polypeptide, neuropeptide Y, nitric oxide synthase, and (in the pig) somatostatin, supplying particularly the lamina propria; and (3) non-noradrenergic, presumably sensory fibres, containing calcitonin gene-related peptide and/or substance P.
nitric oxide synthase Binding (containing) of in nerve associated with somatostatin, neuropeptide, substance p and calcitonin gene-related peptide
2) Confidence 0.36 Published 1998 Journal Microsc. Res. Tech. Section Abstract Doc Link 9817548 Disease Relevance 0.09 Pain Relevance 0.30
The final shaping of AngII signaling depends on cross-talk between nNOS and AngII receptors at both molecular and protein levels.
nNOS Binding (cross-talk) of
3) Confidence 0.36 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15519680 Disease Relevance 0.36 Pain Relevance 0.06
Our results point to an involvement of KOR and nNOS in the same intracellular network that controls the development of morphine tolerance and dependence.
nNOS Binding (point) of associated with addiction, tolerance and morphine
4) Confidence 0.34 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15950775 Disease Relevance 0.32 Pain Relevance 1.50
The aim of this study was to investigate the possibility of synergistic interaction between 1-(2-trifluoromethylphenyl)-imidazole (TRIM), a novel neuronal nitric oxide synthase (nNOS) inhibitor and conventional antidepressants of different classes in the forced swimming test (FST) in rats.
nNOS Binding (interaction) of in neuronal associated with antidepressant and neuronal nitric oxide synthase
5) Confidence 0.31 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18565575 Disease Relevance 0.09 Pain Relevance 0.53
Is neuroprotective efficacy of nNOS inhibitor 7-NI dependent on ischemic intracellular pH?
nNOS Binding (efficacy) of
6) Confidence 0.29 Published 2003 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 12388221 Disease Relevance 0.51 Pain Relevance 0.22
The persistent upregulation of HSP27 and its colocalization with nNOS in surviving motor neurons may imply a keen competition in motor neuron survival between cytotoxic and cytoprotective systems.
nNOS Binding (colocalization) of in motor neurons
7) Confidence 0.28 Published 2003 Journal Arch. Histol. Cytol. Section Abstract Doc Link 12703557 Disease Relevance 0.27 Pain Relevance 0
For central synapses, an alternative approach is depicted in Fig. 4. nNOS in synapses is frequently physically associated with NMDA receptors and is activated when NMDA receptor channels open, allowing an influx of Ca2+.
nNOS Binding (associated) of in synapses associated with nmda receptor
8) Confidence 0.27 Published 2009 Journal Nitric Oxide Section Body Doc Link PMC2779337 Disease Relevance 0 Pain Relevance 0.19
The mechanisms of NO formation by the three NO synthase enzymes (neuronal, endothelial and inducible, or nNOS, eNOS and iNOS) have become quite well established and their functioning in a cell-free environment can be modelled with a good degree of accuracy [8].
nNOS Neg (NO) Binding (formation) of in neuronal
9) Confidence 0.27 Published 2009 Journal Nitric Oxide Section Body Doc Link PMC2779337 Disease Relevance 0 Pain Relevance 0.24
Each NMDA receptor can only associate with one nNOS molecule and a typical postsynaptic membrane may contain up to 50 NMDA receptors [115] and, therefore, may have associated with it a similar number of nNOS molecules.
nNOS Binding (associate) of in postsynaptic membrane associated with nmda receptor
10) Confidence 0.27 Published 2009 Journal Nitric Oxide Section Body Doc Link PMC2779337 Disease Relevance 0 Pain Relevance 0.19
Immunoreactivity for nNOS was not observed in cough receptor nerve terminals in the tracheal submucosa (identified using ?
nNOS Binding (Immunoreactivity) of in nerve associated with cough
11) Confidence 0.26 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0.10 Pain Relevance 0.07
Immunoreactivity for nNOS was observed in many neurons in the nodose ganglia, albeit with two quite distinct patterns of expression.
nNOS Binding (Immunoreactivity) of in neurons
12) Confidence 0.23 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0 Pain Relevance 0.52
In particular, the value of K(i) for clonidine binding to NOS-I increased (from [7. 9 +/- 0.4] x 10(-5) M to [8.0 +/- 0.4] x 10(-3) M) as BH(4) concentration was increased (between 3.0 x 10(-7) M and 1.0 x 10(-3) M), at pH 7.5 and 37.0 degrees.
NOS-I Binding (binding) of associated with clonidine
13) Confidence 0.15 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10874128 Disease Relevance 0.36 Pain Relevance 0.84
However, the value of K(i) for clonidine binding to NOS-I depended on tetrahydrobiopterin (BH(4)) concentration, as reported for NOS inhibition by other nitrogen heterocyclic compounds.
NOS-I Binding (binding) of associated with tetrahydrobiopterin and clonidine
14) Confidence 0.15 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10874128 Disease Relevance 0.30 Pain Relevance 0.79
iNOS is expressed following inflammatory or growth factor stimulation of cells unlike its counterpart eNOS (endothelial nitric oxide synthase) and nNOS (neuronal nitric oxide synthase) which are constitutively expressed.
nNOS Binding (counterpart) of in neuronal associated with inflammation and neuronal nitric oxide synthase
15) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.16 Pain Relevance 0.21

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