INT695

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Context Info
Confidence 0.48
First Reported 1978
Last Reported 2010
Negated 11
Speculated 11
Reported most in Abstract
Documents 304
Total Number 315
Disease Relevance 56.66
Pain Relevance 126.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
plasma 18
melanocyte 16
CSF 5
lymphocytes 5
brain 5
POMC (Homo sapiens)
POMC - A118G (1)
Pain Link Frequency Relevance Heat
Enkephalin 635 100.00 Very High Very High Very High
Opioid 256 100.00 Very High Very High Very High
narcan 192 100.00 Very High Very High Very High
agonist 159 100.00 Very High Very High Very High
antagonist 117 100.00 Very High Very High Very High
opioid receptor 111 100.00 Very High Very High Very High
Neuropeptide 85 100.00 Very High Very High Very High
substance P 76 100.00 Very High Very High Very High
Dynorphin 70 100.00 Very High Very High Very High
Analgesic 69 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adrenal Cancer 139 100.00 Very High Very High Very High
Headache 37 100.00 Very High Very High Very High
Heart Rate Under Development 30 100.00 Very High Very High Very High
Pheochromocytoma 22 100.00 Very High Very High Very High
Small Cell Lung Cancer 4 100.00 Very High Very High Very High
Acromegaly 83 99.92 Very High Very High Very High
Ileus 4 99.90 Very High Very High Very High
Neuroblastoma 13 99.84 Very High Very High Very High
Disease 128 99.72 Very High Very High Very High
Reprotox - General 2 6 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With longer incubation times the specific association of the labeled beta-endorphin with the cells decreased.
beta-endorphin Binding (association) of
1) Confidence 0.48 Published 1986 Journal Cell Biol. Int. Rep. Section Abstract Doc Link 3017583 Disease Relevance 0 Pain Relevance 0.22
This observation, together with the close topographical association of dopamine and Met-enkephalin in the substantia nigra, further supports the likely existence of important functional relationships between dopaminergic and enkephalinergic neurons in the human brain.
Met-enkephalin Binding (association) of in neurons associated with dopamine, substantia nigra and enkephalin
2) Confidence 0.48 Published 1982 Journal Brain Res. Section Abstract Doc Link 7188329 Disease Relevance 0.17 Pain Relevance 1.33
Insights on the interaction of met-enkephalin with negatively charged membranes--an infrared and solid-state NMR spectroscopic study.
met-enkephalin Binding (interaction) of associated with enkephalin
3) Confidence 0.48 Published 2004 Journal Chem. Phys. Lipids Section Title Doc Link 14726000 Disease Relevance 0.09 Pain Relevance 0.77
The results suggest a functional interaction of ACTH 4-9 with serotonergic and dopaminergic brain mechanisms of drugs action.
ACTH Binding (interaction) of in brain
4) Confidence 0.48 Published 1997 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 9223030 Disease Relevance 0 Pain Relevance 0.58
These results suggest that beta-endorphin and enkephalin bind differently to the same receptor or bind to different receptors with overlapping specificity.
beta-endorphin Binding (bind) of associated with enkephalin
5) Confidence 0.48 Published 1979 Journal J. Biol. Chem. Section Abstract Doc Link 217869 Disease Relevance 0 Pain Relevance 0.83
These results suggest that beta-endorphin and enkephalin bind differently to the same receptor or bind to different receptors with overlapping specificity.
beta-endorphin Binding (bind) of associated with enkephalin
6) Confidence 0.48 Published 1979 Journal J. Biol. Chem. Section Abstract Doc Link 217869 Disease Relevance 0 Pain Relevance 0.83
However, the effects of various cations on the binding of 125I-[D-Ala2]beta-endorphin are markedly different from those found for enkephalin binding.
beta-endorphin Binding (binding) of associated with enkephalin
7) Confidence 0.48 Published 1979 Journal J. Biol. Chem. Section Abstract Doc Link 217869 Disease Relevance 0 Pain Relevance 0.86
Moreover, potassium (100 mM) decreases the binding of beta-endorphin but does not affect enkephalin binding.
beta-endorphin Binding (binding) of associated with enkephalin
8) Confidence 0.48 Published 1979 Journal J. Biol. Chem. Section Abstract Doc Link 217869 Disease Relevance 0 Pain Relevance 0.85
Influence on memory of posttraining or pre-test injections of ACTH, vasopressin, epinephrine, and beta-endorphin, and their interaction with naloxone.
beta-endorphin Binding (interaction) of associated with narcan
9) Confidence 0.48 Published 1985 Journal Psychoneuroendocrinology Section Title Doc Link 2994140 Disease Relevance 0 Pain Relevance 0.31
Recently, in addition to its well-known pigmentation inducing activity, a strong anti-inflammatory as well as an immunomodulatory potential of alpha-melanocyte-stimulating hormone has been recognized.
alpha-melanocyte-stimulating hormone Binding (recognized) of in melanocyte associated with inflammation
10) Confidence 0.48 Published 2004 Journal J. Invest. Dermatol. Section Abstract Doc Link 15009732 Disease Relevance 0.41 Pain Relevance 0.30
The mutants Asp84Glu and Asp294His showed a much lower response to alpha-MSH in cAMP and a slightly impaired ability to bind alpha-MSH, and the Val92Met mutant bound alpha-MSH with 100-fold lower affinity as compared with the wild-type.
alpha-MSH Binding (bound) of
11) Confidence 0.48 Published 2004 Journal J. Invest. Dermatol. Section Abstract Doc Link 15482480 Disease Relevance 0.14 Pain Relevance 0.12
In order to determine the functional significance of these mutations, we expressed the Asp84Glu, Val92Met, Arg163Gln, and Asp294His variants of the human MC1 receptors in eukaryotic cells and determined their ability to bind alpha-melanocyte stimulating hormone (MSH) peptides and increase intracellular cAMP.
MSH Spec (determined) Binding (bind) of in melanocyte
12) Confidence 0.48 Published 2004 Journal J. Invest. Dermatol. Section Abstract Doc Link 15482480 Disease Relevance 0.16 Pain Relevance 0.11
In order to determine the functional significance of these mutations, we expressed the Asp84Glu, Val92Met, Arg163Gln, and Asp294His variants of the human MC1 receptors in eukaryotic cells and determined their ability to bind alpha-melanocyte stimulating hormone (MSH) peptides and increase intracellular cAMP.
alpha-melanocyte stimulating hormone Spec (determined) Binding (bind) of in melanocyte
13) Confidence 0.48 Published 2004 Journal J. Invest. Dermatol. Section Abstract Doc Link 15482480 Disease Relevance 0.16 Pain Relevance 0.11
Thus, beta-endorphin and immunorphin interact with common naloxone-insensitive receptors on T lymphocytes.
beta-endorphin Binding (interact) of in T lymphocytes associated with narcan
14) Confidence 0.48 Published 2002 Journal Biochemistry Mosc. Section Abstract Doc Link 11970735 Disease Relevance 0 Pain Relevance 0.38
Using in vitro cellular expression assays, this variant has been reported to change binding of the endogenous agonist beta-endorphin and signaling of the receptor following binding of beta-endorphin.
beta-endorphin Binding (binding) of associated with agonist
15) Confidence 0.47 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17877633 Disease Relevance 0.06 Pain Relevance 0.34
Using in vitro cellular expression assays, this variant has been reported to change binding of the endogenous agonist beta-endorphin and signaling of the receptor following binding of beta-endorphin.
beta-endorphin Binding (binding) of associated with agonist
16) Confidence 0.47 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17877633 Disease Relevance 0.07 Pain Relevance 0.38
Fractions were also analyzed by immunoblots using a monoclonal antibody that recognizes the N-terminus of human beta-endorphin.
beta-endorphin Spec (analyzed) Binding (recognizes) of
17) Confidence 0.47 Published 2004 Journal J. Eukaryot. Microbiol. Section Abstract Doc Link 15068266 Disease Relevance 0 Pain Relevance 0.42
This is consistent with the requirement that Met-enkephalin be sufficiently flexible to bind to several different receptors.
Met-enkephalin Binding (bind) of associated with enkephalin
18) Confidence 0.47 Published 2002 Journal Proteins Section Abstract Doc Link 11807951 Disease Relevance 0 Pain Relevance 0.50
Interaction of Leu- and Met-enkephalin with phosphatidylserine has been studied by chromatographic and spectrophotometric techniques.
Met-enkephalin Binding (Interaction) of associated with enkephalin
19) Confidence 0.47 Published 1984 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 6724805 Disease Relevance 0 Pain Relevance 0.34
Interaction of met-enkephalin with human granulocytes.
met-enkephalin Binding (Interaction) of in granulocytes associated with enkephalin
20) Confidence 0.47 Published 1987 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 3037971 Disease Relevance 0 Pain Relevance 0.47

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