INT69528

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Context Info
Confidence 0.45
First Reported 1996
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 4.27
Pain Relevance 8.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprk1) plasma membrane (Oprk1) signal transducer activity (Oprk1)
Anatomy Link Frequency
nerve 2
brain 2
nervous system 2
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 119 100.00 Very High Very High Very High
Enkephalin 20 100.00 Very High Very High Very High
opioid receptor 156 99.72 Very High Very High Very High
tolerance 9 99.40 Very High Very High Very High
dorsal root ganglion 25 99.38 Very High Very High Very High
allodynia 14 99.32 Very High Very High Very High
Antinociceptive 11 99.00 Very High Very High Very High
Delta opioid receptors 3 99.00 Very High Very High Very High
alcohol 73 98.28 Very High Very High Very High
analgesia 64 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 17 99.66 Very High Very High Very High
Hypoxia 12 99.64 Very High Very High Very High
Ganglion Cysts 50 99.38 Very High Very High Very High
Neuropathic Pain 26 99.32 Very High Very High Very High
Alcohol Addiction 70 98.28 Very High Very High Very High
INFLAMMATION 73 98.00 Very High Very High Very High
Convulsion 7 94.12 High High
Urological Neuroanatomy 9 90.72 High High
Death 1 87.44 High High
Rheumatoid Arthritis 2 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A regulatory variation in OPRK1, the gene encoding the ?
Regulation (regulatory) of Gene_expression (variation) of OPRK1
1) Confidence 0.45 Published 2008 Journal Human Molecular Genetics Section Title Doc Link PMC2405904 Disease Relevance 0.31 Pain Relevance 0.32
A regulatory variation in OPRK1, the gene encoding the ?
Regulation (encoding) of Gene_expression (variation) of OPRK1
2) Confidence 0.45 Published 2008 Journal Human Molecular Genetics Section Title Doc Link PMC2405904 Disease Relevance 0.31 Pain Relevance 0.32
Effects of KOR inhibition on astrocytic Responses
Regulation (Effects) of Gene_expression (inhibition) of KOR associated with kappa opioid receptor
3) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.15 Pain Relevance 0.49
The same hypoxic treatment had no effects on either mu or kappa opioid receptor expression, indicating that this response was not due to non-selective degradation of protein.
Neg (no) Regulation (effects) of Gene_expression (expression) of kappa opioid receptor associated with hypoxia and kappa opioid receptor
4) Confidence 0.27 Published 1996 Journal Neuroscience Section Abstract Doc Link 9157323 Disease Relevance 0.74 Pain Relevance 0.47
These results show that KOR mRNA expression differs between PB+ and PB- groups of mice after nerve injury, and suggest an association of KOR expression with mechanical allodynia.
Regulation (association) of Gene_expression (expression) of KOR in nerve associated with nervous system injury, allodynia and kappa opioid receptor
5) Confidence 0.27 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10984632 Disease Relevance 0.72 Pain Relevance 0.75
In noncortical regions kappa-opioid receptor expression was unchanged.
Neg (unchanged) Regulation (unchanged) of Gene_expression (expression) of kappa-opioid receptor associated with kappa opioid receptor
6) Confidence 0.17 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12653976 Disease Relevance 0 Pain Relevance 0.58
Alteration of kappa-opioid receptor system expression in distinct brain regions of a genetic model of enhanced ethanol withdrawal severity.
Regulation (Alteration) of Gene_expression (expression) of kappa-opioid receptor in brain associated with kappa opioid receptor, enkephalin and withdrawal
7) Confidence 0.16 Published 2005 Journal Brain Res. Section Title Doc Link 15869750 Disease Relevance 0.39 Pain Relevance 0.73
No other significant changes in KOR expression were observed in the other regions.
Neg (No) Regulation (changes) of Gene_expression (expression) of KOR associated with kappa opioid receptor
8) Confidence 0.09 Published 2010 Journal Brain Res. Section Abstract Doc Link 20206145 Disease Relevance 0.18 Pain Relevance 2.25
As such, the changes in KOR expression in different regions of the nervous system in morphine tolerant rats were examined.
Spec (examined) Regulation (changes) of Gene_expression (expression) of KOR in nervous system associated with kappa opioid receptor and morphine
9) Confidence 0.09 Published 2010 Journal Brain Res. Section Abstract Doc Link 20206145 Disease Relevance 0.13 Pain Relevance 2.06
Adding further complexity; changes in KOR and DOR expression have also been reported in nonneuronal cells.
Regulation (changes) of Gene_expression (expression) of KOR
10) Confidence 0.09 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.96 Pain Relevance 0.72
In DRG culture, to exclude extrinsic effects on KOR expression, NGF and N2 supplements were excluded from the medium during DRG culture.
Regulation (effects) of Gene_expression (expression) of KOR associated with dorsal root ganglion
11) Confidence 0.01 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0.38 Pain Relevance 0.15

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