INT6955

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.60
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGIS) small molecule metabolic process (PTGIS) endoplasmic reticulum (PTGIS)
lipid metabolic process (PTGIS)
Anatomy Link Frequency
endothelial cells 2
uterine 2
PTGIS (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 53 98.72 Very High Very High Very High
cINOD 33 78.20 Quite High
agonist 1 26.64 Quite Low
Dismenorea 1 25.00 Low Low
bradykinin 11 6.16 Low Low
Inflammation 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pre-eclampsia 33 99.32 Very High Very High Very High
Arthritis 3 90.12 High High
Disease 15 87.24 High High
Injury 1 75.12 Quite High
Syndrome 4 47.04 Quite Low
Hypertension 5 45.84 Quite Low
Proteinuria 1 44.72 Quite Low
Cognitive Disorder 1 40.52 Quite Low
Dementia 2 38.80 Quite Low
Hypoxia 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While estrogen leads to increased production of PGF2alpha, progesterone stimulates the production of prostacyclin synthase, Mifepristone, which blocks progesterone at the receptor level, increases uterine activity and sensitivity to PG.
Positive_regulation (stimulates) of Gene_expression (production) of prostacyclin synthase in uterine
1) Confidence 0.36 Published 1992 Journal Baillieres Clin Obstet Gynaecol Section Abstract Doc Link 1335853 Disease Relevance 0 Pain Relevance 0
VEGF and plasma from women with preeclampsia induce a concentration-dependent increase in prostacyclin production in bovine endothelial cells, which is inhibited by VEGF antibody[62].
Positive_regulation (increase) of Gene_expression (production) of prostacyclin in endothelial cells associated with pre-eclampsia
2) Confidence 0.07 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.22 Pain Relevance 0
We estimated systemic biosynthesis of thromboxane (Tx) A2, which derives predominantly from the catalytic action of COX-1, and prostacyclin (PGI2), which derives predominantly from the catalytic action of COX-2, by quantifying their respective major urinary metabolites, 11-dehydrothromboxane B2 (Tx-M) and 2?
Positive_regulation (estimated) of Gene_expression (biosynthesis) of prostacyclin
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824826 Disease Relevance 0.38 Pain Relevance 0.29

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox