INT6956

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Context Info
Confidence 0.76
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 29
Total Number 32
Disease Relevance 12.10
Pain Relevance 3.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGIS) small molecule metabolic process (PTGIS) endoplasmic reticulum (PTGIS)
lipid metabolic process (PTGIS)
Anatomy Link Frequency
smooth muscle cells 3
vasculature 2
follicular dendritic cells 2
blood 1
endothelial cells 1
PTGIS (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 151 100.00 Very High Very High Very High
COX2 17 100.00 Very High Very High Very High
headache 40 99.78 Very High Very High Very High
cytokine 9 99.14 Very High Very High Very High
Inflammation 40 98.94 Very High Very High Very High
bradykinin 67 98.68 Very High Very High Very High
COX-2 inhibitor 12 98.68 Very High Very High Very High
aspirin 110 97.96 Very High Very High Very High
cINOD 80 94.64 High High
Potency 1 92.96 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 177 100.00 Very High Very High Very High
Headache 38 99.78 Very High Very High Very High
Thrombosis 29 99.56 Very High Very High Very High
Pre-eclampsia 198 99.08 Very High Very High Very High
Missed Abortion 3 99.08 Very High Very High Very High
INFLAMMATION 53 98.94 Very High Very High Very High
Nicotine Addiction 51 98.40 Very High Very High Very High
Pulmonary Hypertension 688 98.28 Very High Very High Very High
Nociception 1 98.20 Very High Very High Very High
Reprotox - General 1 4 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have recently demonstrated that human follicular dendritic cells (FDCs) strongly express prostacyclin synthase.
Gene_expression (express) of prostacyclin in follicular dendritic cells
1) Confidence 0.76 Published 2007 Journal Mol. Immunol. Section Abstract Doc Link 17337058 Disease Relevance 0.21 Pain Relevance 0.08
Specifically in response to TNF-alpha, TGF-beta, and LPS, protein expression of cyclooxygenase (COX)-2 and downstream PGE synthase was up-regulated with coordinate kinetics, whereas COX-1 and PGIS were constitutively expressed.
Gene_expression (expressed) of PGIS
2) Confidence 0.75 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18209033 Disease Relevance 0.27 Pain Relevance 0.04
The levels of PGIS protein expression did not vary during the different stages of the cell cycle.
Gene_expression (expression) of PGIS
3) Confidence 0.67 Published 2007 Journal Mol. Immunol. Section Abstract Doc Link 17337058 Disease Relevance 0.25 Pain Relevance 0.12
Prostacyclin production is not controlled by prostacyclin synthase but by cyclooxygenase-2 in a human follicular dendritic cell line, HK.
Gene_expression (production) of Prostacyclin in follicular dendritic cell associated with cox2
4) Confidence 0.67 Published 2007 Journal Mol. Immunol. Section Title Doc Link 17337058 Disease Relevance 0.23 Pain Relevance 0.27
While estrogen leads to increased production of PGF2alpha, progesterone stimulates the production of prostacyclin synthase, Mifepristone, which blocks progesterone at the receptor level, increases uterine activity and sensitivity to PG.
Gene_expression (production) of prostacyclin synthase in uterine
5) Confidence 0.55 Published 1992 Journal Baillieres Clin Obstet Gynaecol Section Abstract Doc Link 1335853 Disease Relevance 0 Pain Relevance 0
These results suggest that the production of prostacyclin in FDC is controlled by the regulation of upstream COX-2 but not by terminal PGIS protein production.
Gene_expression (production) of prostacyclin
6) Confidence 0.52 Published 2007 Journal Mol. Immunol. Section Abstract Doc Link 17337058 Disease Relevance 0.26 Pain Relevance 0.22
These results suggest that the production of prostacyclin in FDC is controlled by the regulation of upstream COX-2 but not by terminal PGIS protein production.
Neg (not) Gene_expression (production) of PGIS
7) Confidence 0.52 Published 2007 Journal Mol. Immunol. Section Abstract Doc Link 17337058 Disease Relevance 0.25 Pain Relevance 0.22
The purpose of this study is to investigate the production mechanism of prostacyclin using the established human FDC line, HK.
Spec (investigate) Gene_expression (production) of prostacyclin
8) Confidence 0.52 Published 2007 Journal Mol. Immunol. Section Abstract Doc Link 17337058 Disease Relevance 0.24 Pain Relevance 0.11
We stimulated HK cells with various inflammatory cytokines but, none of the tested stimuli modulated PGIS expression significantly.
Gene_expression (expression) of PGIS associated with inflammation and cytokine
9) Confidence 0.52 Published 2007 Journal Mol. Immunol. Section Abstract Doc Link 17337058 Disease Relevance 0.29 Pain Relevance 0.19
This is followed by PGIS-PGDS having 12 common features. mPGES-2 on the other hand is found to be more similar to PGIS which is a heme bound enzyme, than to PGDS.
Gene_expression (followed) of PGIS
10) Confidence 0.32 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC3009524 Disease Relevance 0 Pain Relevance 0
In PAH, there is imbalance between this vasodilator and other vasoconstrictor molecules, with decreased expression of prostacyclin synthase and increased levels of thromboxane A2.12,15 In addition to vasodilation, prostacyclin has an antiproliferative effect on smooth muscle cells in vitro.48 Abnormal levels of prostacyclin facilitate the medial hypertrophy seen in PAH.
Gene_expression (synthase) of prostacyclin in smooth muscle cells associated with hypertrophy, pulmonary hypertension and increased venous pressure under development
11) Confidence 0.32 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004515 Disease Relevance 0.97 Pain Relevance 0
Prostacyclin is an endogenous vasodilator produced by prostacyclin synthase in endothelial cells of the pulmonary vasculature.
Gene_expression (synthase) of prostacyclin in vasculature
12) Confidence 0.32 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004515 Disease Relevance 0.60 Pain Relevance 0
Included in these medications are endothelin receptor antagonists, phosphodiesterase inhibitors, and prostacyclin analogs, such as treprostinil.
Gene_expression (antagonists) of prostacyclin associated with antagonist
13) Confidence 0.28 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004515 Disease Relevance 0.63 Pain Relevance 0.09
Prostacyclin is an endogenous vasodilator produced by prostacyclin synthase in endothelial cells of the pulmonary vasculature.
Gene_expression (produced) of Prostacyclin in vasculature
14) Confidence 0.28 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004515 Disease Relevance 0.59 Pain Relevance 0
Furthermore, prostacyclin prevents platelet activation and aggregation by thromboxane A2.49 Reduced levels of prostacyclin allow for thrombosis in situ also seen in PAH.
Gene_expression (levels) of prostacyclin in platelet associated with pulmonary hypertension and thrombosis
15) Confidence 0.28 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004515 Disease Relevance 1.08 Pain Relevance 0
Occupancy of endothelial ET-B receptors leads primarily to vasodilation and induction of nitric oxide and prostacyclin production.
Gene_expression (production) of prostacyclin associated with increased venous pressure under development
16) Confidence 0.28 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004515 Disease Relevance 0.88 Pain Relevance 0.21
In PAH, there is imbalance between this vasodilator and other vasoconstrictor molecules, with decreased expression of prostacyclin synthase and increased levels of thromboxane A2.12,15 In addition to vasodilation, prostacyclin has an antiproliferative effect on smooth muscle cells in vitro.48 Abnormal levels of prostacyclin facilitate the medial hypertrophy seen in PAH.
Gene_expression (synthase) of prostacyclin in smooth muscle cells associated with hypertrophy, pulmonary hypertension and increased venous pressure under development
17) Confidence 0.28 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004515 Disease Relevance 1.07 Pain Relevance 0
The headache eliciting effects of prostacyclin (prostaglandin I(2), (PGI(2))) and its possible mechanisms had previously not been systematically studied in man.
Gene_expression (effects) of prostacyclin associated with headache
18) Confidence 0.19 Published 2008 Journal Pain Section Abstract Doc Link 18450380 Disease Relevance 0.52 Pain Relevance 0.33
PatchDock successfully detected the surface pockets of PGDS, PGES, PGFS and PGIS and they are in agreement with previously published data [22-30]on the putative binding site of PGH2.
Gene_expression (detected) of PGIS
19) Confidence 0.12 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC3009524 Disease Relevance 0 Pain Relevance 0
PGI2 produced by PGIS, and TXA2 produced by TXAS, are critical for the maintenance of homeostasis in the vascular tissue [6,7].
Gene_expression (produced) of PGIS
20) Confidence 0.12 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC3009524 Disease Relevance 0.73 Pain Relevance 0.38

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