INT69561

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Context Info
Confidence 0.50
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 5.69
Pain Relevance 6.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTM1) small molecule metabolic process (GSTM1) cytoplasm (GSTM1)
Anatomy Link Frequency
blood 1
lymphocytes 1
brain 1
external 1
primary sensory neurons 1
GSTM1 (Homo sapiens)
GSTM1 - I1575A (2) GSTM1 - N434W (2)
Pain Link Frequency Relevance Heat
Potency 17 100.00 Very High Very High Very High
Inflammation 52 99.74 Very High Very High Very High
opioid receptor 15 99.60 Very High Very High Very High
Morphine 29 99.38 Very High Very High Very High
analgesia 106 99.16 Very High Very High Very High
Physical dependence 4 99.14 Very High Very High Very High
Antihyperalgesic 10 98.92 Very High Very High Very High
depression 16 95.88 Very High Very High Very High
mu opioid receptor 4 95.76 Very High Very High Very High
nMDA receptor 2 94.64 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 61 99.74 Very High Very High Very High
Rheumatoid Arthritis 115 99.24 Very High Very High Very High
Drug Dependence 4 99.14 Very High Very High Very High
Nicotine Addiction 71 98.84 Very High Very High Very High
Toxicity 43 97.88 Very High Very High Very High
Second Primary Neoplasms 1 97.88 Very High Very High Very High
Respiratory Failure 14 96.36 Very High Very High Very High
Heart Rate Under Development 5 95.40 Very High Very High Very High
Gastric Motility Disorder 1 93.88 High High
Obesity 23 88.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
INTERPRETATION & CONCLUSION: The study results suggested that women having higher concentration of PCBs and GSTM1 null (*0/*0) polymorphism might have an increased susceptibility of endometriosis.
Positive_regulation (concentration) of GSTM1
1) Confidence 0.50 Published 2009 Journal Indian J. Med. Res. Section Body Doc Link 19535834 Disease Relevance 0.05 Pain Relevance 0
Mu receptors are present as two types: mu1, when activated produce supraspinal analgesia and physical dependence; mu 2 receptors are responsible for respiratory depression, bradycardia, physical dependence, and gastrointestinal dysmotility.
Positive_regulation (activated) of mu1 in respiratory associated with heart rate under development, depression, physical dependence, respiratory failure, gastric motility disorder and analgesia
2) Confidence 0.49 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004641 Disease Relevance 0.67 Pain Relevance 1.92
In inactivated channels, the potency of bupivacaine was increased in mutations containing a quadrupole of an aromatic group (mu1-N434F, mu1-N434W, mu1-N434Y), a polar group (mu1-N434C), or a negative charge (mu1-N434D) and was decreased in a mutation containing a positive charge (mu1-N434K).
Positive_regulation (increased) of mu1 (N434F, N434W) associated with potency
3) Confidence 0.49 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419561 Disease Relevance 0 Pain Relevance 0.59
In inactivated channels, the potency of bupivacaine was increased in mutations containing a quadrupole of an aromatic group (mu1-N434F, mu1-N434W, mu1-N434Y), a polar group (mu1-N434C), or a negative charge (mu1-N434D) and was decreased in a mutation containing a positive charge (mu1-N434K).
Positive_regulation (increased) of mu1 (N434Y, N434W) associated with potency
4) Confidence 0.49 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419561 Disease Relevance 0 Pain Relevance 0.59
This increased potency of external QX-314 against the mu1-I1575A mutant has been reported previously in a study of the brain counterpart.
Positive_regulation (increased) of mu1 (I1575A) in brain associated with potency
5) Confidence 0.49 Published 1998 Journal Pflugers Arch. Section Abstract Doc Link 9382945 Disease Relevance 0 Pain Relevance 0.24
We hypothesize that an increase in accessibility of external QX-314 to the mu1-I1575A mutant is accompanied by a reduction of binding towards the charged amine component.
Positive_regulation (increase) of mu1 (I1575A) in external
6) Confidence 0.49 Published 1998 Journal Pflugers Arch. Section Abstract Doc Link 9382945 Disease Relevance 0 Pain Relevance 0.15
To our knowledge, one study assessed genetic polymorphisms and susceptibility to radiotherapy-related malignancies, but only evaluated GSTM1 and GSTT1, finding nonsignificant elevated risk for second cancers among those with gene deletions [26].
Positive_regulation (evaluated) of GSTM1 associated with second primary neoplasms
7) Confidence 0.48 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779469 Disease Relevance 0.54 Pain Relevance 0
For example, genotoxicity of TSO in cultured human lymphocytes (as measured by induction of sister chromatid exchanges) is significantly elevated in GSTM1-null individuals [67], and, as discussed later, clinical toxicity of methyl bromide may be strongly determined by GSTT1 genotype.
Positive_regulation (elevated) of GSTM1-null in lymphocytes associated with toxicity
8) Confidence 0.47 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0.10 Pain Relevance 0
Analysis of DNA adducts and cytogenetic endpoints have indicated an increased susceptibility of glutathione S-transferase M1 and/or T1 (GSTM1, GSTT1) null genotype to genotoxicity of common low-dose chemicals [7-9].
Positive_regulation (increased) of GSTM1
9) Confidence 0.46 Published 2007 Journal Environ Health Section Body Doc Link PMC1802749 Disease Relevance 0.42 Pain Relevance 0
Analysis of DNA adducts and cytogenetic endpoints have indicated an increased susceptibility of glutathione S-transferase M1 and/or T1 (GSTM1, GSTT1) null genotype to genotoxicity of common low-dose chemicals [7-9].
Positive_regulation (increased) of glutathione S-transferase M1
10) Confidence 0.46 Published 2007 Journal Environ Health Section Body Doc Link PMC1802749 Disease Relevance 0.42 Pain Relevance 0
Copy number variation: CYP2A6, CYP2D6, GSTM1, GSTT1 and 1500 other such sites
Positive_regulation (variation) of GSTM1
11) Confidence 0.34 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.17 Pain Relevance 0
The most frequent genotypes in the sample were CYP1A1 wt/wt, with GSTM1 null deletion and at least one functional allele of GSTT1, and CYP1A1 wt/wt, with at least one functional allele of GSTM1 and GSTT1 (33% and 31%, respectively).
Positive_regulation (allele) of GSTM1
12) Confidence 0.28 Published 2001 Journal Fertil. Steril. Section Body Doc Link 11730751 Disease Relevance 0.06 Pain Relevance 0
level and blood WBC count were evaluated after stratification according to the GSTM1 or GSTP1 gene polymorphism to estimate whether the GSTM1 and GSTP1 gene polymorphisms modify the relation between smoking and serum TNF-?
Positive_regulation (polymorphisms) of GSTM1 in blood associated with nicotine addiction
13) Confidence 0.22 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 0.94 Pain Relevance 0.07
In selected cases, RA combines advantages of short treatment time with less number of MU and better conformity in addition to accuracy of stereotactic localisation, but with larger low dose areas in comparison to conventional cone based SRS.
Positive_regulation (number) of MU associated with rheumatoid arthritis
14) Confidence 0.20 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2949676 Disease Relevance 0.40 Pain Relevance 0.07
Dose to the OAR and low dose volume were assessed as clear benefit for CAT, even though treatment time and number of MU were better using RA.
Positive_regulation (number) of MU associated with rheumatoid arthritis
15) Confidence 0.20 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2949676 Disease Relevance 0.81 Pain Relevance 0.14
On the other hand, the chronic administration induced a significant hypoactivation of S1M1 whatever the task: motor or sensory, simple or complex (random effect analysis, P<0.05).
Positive_regulation (hypoactivation) of S1M1 in S1M1
16) Confidence 0.19 Published 2005 Journal Neuroimage Section Abstract Doc Link 15950492 Disease Relevance 0 Pain Relevance 0.19
Peripheral inflammation leads to an increase in mu receptor present on the peripheral terminals of primary sensory neurons.
Positive_regulation (increase) of mu in primary sensory neurons associated with inflammation
17) Confidence 0.14 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15054116 Disease Relevance 0.21 Pain Relevance 0.41
Activation of peripheral mu receptors produces potent antihyperalgesic effects in both humans and animals.
Positive_regulation (Activation) of mu associated with antihyperalgesic
18) Confidence 0.10 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15054116 Disease Relevance 0.22 Pain Relevance 0.43
Despite a considerable increase in interest in the function and natural history of the GTM and in strategies for its therapeutic compositional manipulation, insight into the broad contributions of host genetics versus environmental factors upon development, composition and maintenance of the GTM remains incomplete and there are relatively few reports addressing this in the literature, probably due to difficulties associated with experimentally separating environmental from genetic influences.
Positive_regulation (increase) of GTM
19) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798964 Disease Relevance 0.09 Pain Relevance 0.04
Despite a considerable increase in interest in the function and natural history of the GTM and in strategies for its therapeutic compositional manipulation, insight into the broad contributions of host genetics versus environmental factors upon development, composition and maintenance of the GTM remains incomplete and there are relatively few reports addressing this in the literature, probably due to difficulties associated with experimentally separating environmental from genetic influences.
Positive_regulation (maintenance) of GTM
20) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798964 Disease Relevance 0.08 Pain Relevance 0.04

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