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Context Info
Confidence 0.01
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.19
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (AP2M1, Adrb3) transport (AP2M1) mitochondrion (AP2M1)
aging (Adrb3) signal transducer activity (Adrb3) cytosol (AP2M1)
Anatomy Link Frequency
locus coeruleus 3
AP2M1 (Homo sapiens)
Adrb3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 9 100.00 Very High Very High Very High
nMDA receptor 1 99.80 Very High Very High Very High
Morphine 2 99.38 Very High Very High Very High
Physical dependence 2 99.14 Very High Very High Very High
Locus ceruleus 1 98.96 Very High Very High Very High
agonist 7 92.08 High High
Kappa opioid receptor 4 91.72 High High
addiction 6 91.04 High High
Central nervous system 1 84.52 Quite High
Dopamine 2 76.88 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 2 99.14 Very High Very High Very High
Cancer Pain 1 26.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From behavioral, biochemical and molecular biological studies, it is suggested so far that development of physical dependence on morphine results predominantly from an activation of mu 1 and mu 2 opioid receptors which causes functional changes in Gi/o, adenylate cyclase, protein kinases A and C, beta-adrenoceptor and NMDA receptor in the locus coeruleus.
Positive_regulation (activation) of mu 2 in locus coeruleus Positive_regulation (causes) of Regulation (changes) of beta-adrenoceptor in locus coeruleus associated with physical dependence, locus ceruleus, nmda receptor, opioid receptor and morphine
1) Confidence 0.01 Published 1997 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 9160346 Disease Relevance 0.19 Pain Relevance 1.24

General Comments

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