INT69564

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Context Info
Confidence 0.34
First Reported 1997
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 4.67
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cyp3a23/3a1) endoplasmic reticulum (Cyp3a23/3a1)
Anatomy Link Frequency
bladder 2
brain 1
Cyp3a23/3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 504 100.00 Very High Very High Very High
Paracetamol 6 98.54 Very High Very High Very High
fluoxetine 6 97.80 Very High Very High Very High
cINOD 3 92.84 High High
cva 2 91.36 High High
Arthritis 102 90.32 High High
tolerance 12 90.20 High High
Inflammation 129 89.92 High High
Serotonin 1 84.32 Quite High
tetrodotoxin 1 80.96 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 306 99.90 Very High Very High Very High
Hyperplasia 4 98.32 Very High Very High Very High
Hepatotoxicity 5 97.40 Very High Very High Very High
Adverse Drug Reaction 30 96.32 Very High Very High Very High
Diabetes Mellitus 14 94.88 High High
Increased Venous Pressure Under Development 2 92.80 High High
INFLAMMATION 123 92.60 High High
Metabolic Syndrome 17 91.76 High High
Hemorrhage 2 91.36 High High
Liver Failure 1 90.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clotrimazole, an imidazole that inhibits CYP by binding to the heme moiety, attenuated ACh, histamine, and cromakalim but not sodium nitroprusside-mediated vasodilator responses.
CYP Binding (binding) of
1) Confidence 0.34 Published 1997 Journal Am. J. Hypertens. Section Abstract Doc Link 9234831 Disease Relevance 0.09 Pain Relevance 0.12
MI complexation of CYP appeared to contribute significantly to inhibition by FLU, as evidenced by the 21% decrease in apparent microsomal CYP content produced by 50 microM FLU in the presence of NADPH. 3.
CYP Spec (appeared) Binding (complexation) of associated with fluoxetine
2) Confidence 0.31 Published 2003 Journal Xenobiotica Section Abstract Doc Link 14555335 Disease Relevance 0 Pain Relevance 0.69
Polymer-analogue reactions were used to conjugate Dex to the HPMA copolymer (Figure 1).
Dex Binding (conjugate) of associated with dexamethasone
3) Confidence 0.31 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.48 Pain Relevance 0.50
The reduction of hydrazide content was due to Dex conjugation and the amount of Dex conjugated was determined as 50 mg/g of polymer conjugate.
Dex Binding (conjugation) of associated with dexamethasone
4) Confidence 0.30 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.17 Pain Relevance 0.40
We studied the effects of TRZ on the hepatotoxicity of carbon tetrachloride (CCl(4)) and acetaminophen (APAP) in rats, both of which exert their toxic effects through bioactivation associated with cytochrome P450 3A (CYP3A) and 2E1 (CYP2E1).
cytochrome P450 3A Binding (associated) of associated with paracetamol and hepatotoxicity
5) Confidence 0.29 Published 2002 Journal Toxicology Section Abstract Doc Link 12062933 Disease Relevance 0.59 Pain Relevance 0.41
We report that both RA and Dex-induced alteration of alveolarization was associated with hypercarbia at two weeks.
Dex-induced Binding (associated) of associated with rheumatoid arthritis and dexamethasone
6) Confidence 0.10 Published 2006 Journal Respir Res Section Body Doc Link PMC1448204 Disease Relevance 0.78 Pain Relevance 0.35
While concomitant treatment with RA (Dex + RA) reversed RAC as compared to Dex alone, this treatment had no effect on the increased RR, MV, or TV seen in association with Dex alone.
Dex Binding (association) of associated with rheumatoid arthritis and dexamethasone
7) Confidence 0.10 Published 2006 Journal Respir Res Section Body Doc Link PMC1448204 Disease Relevance 1.05 Pain Relevance 0.52
Real-time PCR showed that CXCR4 mRNA was significantly upregulated in the bladder following CYP treatment (Figure 5A; ?
CYP Binding (treatment) of in bladder
8) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
Compared to saline treatment, CYP treatment increased urinary MIF levels (as measured by ELISA; Figure 1E; 22.2±2.8 vs. 57.3±20.5 in saline vs CYP, respectively; p<0.0464) while decreasing bladder MIF levels (Fig 1F; 244.1±39.7 vs 136.0±38.1 ng MIF/mg protein in saline vs CYP treatment respectively; p?
CYP Binding (treatment) of in bladder
9) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.56 Pain Relevance 0.13
These estrogens interact with the repressor protein Bm3R1, causing it to dissociate with the operator of the CYP102 gene and allowing transcription to occur.
CYP102 Binding (dissociate) of
10) Confidence 0.05 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9535758 Disease Relevance 0.09 Pain Relevance 0.09
Pitavastatin is non-CYP metabolizable and rarely causes drug–drug interactions through CYP isoforms.
CYP Binding (interactions) of
11) Confidence 0.04 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.62 Pain Relevance 0
Ethanol is metabolized in the brain by catalase/H2O2 to yield acetaldehyde and by an ethanol-inducible form of cytochrome P450 (P450 IIE1) in a reaction that yields oxygen radicals.
P450 IIE1 Binding (metabolized) of in brain
12) Confidence 0.01 Published 1997 Journal Alcohol Section Abstract Doc Link 9160798 Disease Relevance 0.15 Pain Relevance 0

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