INT69568

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Context Info
Confidence 0.50
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.43
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
neuron 2
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 8 78.40 Quite High
ischemia 22 74.12 Quite High
imagery 7 33.12 Quite Low
Hippocampus 7 26.44 Quite Low
Thalamus 4 25.80 Quite Low
Central nervous system 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 9 99.98 Very High Very High Very High
Neurologic Manifestations 3 90.64 High High
Disease 30 89.44 High High
Stress 15 89.44 High High
Sprains And Strains 30 86.60 High High
Scrapie 26 75.00 Quite High
Toxicity 4 75.00 Quite High
Cv Unclassified Under Development 16 74.12 Quite High
Targeted Disruption 18 68.48 Quite High
Apoptosis 3 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other studies (36) have demonstrated that the octapeptide repeat region of PrPC is required for reactive oxygen species-mediated ?
Positive_regulation (required) of Localization (region) of PrPC
1) Confidence 0.50 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.63 Pain Relevance 0.11
Colby et al. reported that sPrPSc was generated in vitro during polymerization of recPrP into amyloid fibers.
Positive_regulation (generated) of Localization (polymerization) of recPrP associated with alzheimer's dementia
2) Confidence 0.44 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2950034 Disease Relevance 0.61 Pain Relevance 0.07
We conclude that pre-amyloid PrP release and accumulation is not invariably toxic, either to the neuron releasing PrP or to the neuropil into which it is released.
Positive_regulation (accumulation) of Localization (release) of PrP in neuron associated with alzheimer's dementia
3) Confidence 0.44 Published 1997 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 9160894 Disease Relevance 1.02 Pain Relevance 0.08
Indeed, when we blocked PrP exit from EEs the levels of PrPSc were drastically reduced and an accumulation of PrPC in EEs was observed (Figures 2A, 2C, 5A, 5B, S8B, S8C and S8D).
Positive_regulation (accumulation) of Localization (exit) of PrP
4) Confidence 0.43 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.08 Pain Relevance 0
These data indicate that quinacrine can both delay the formation and induce the clearance of PrPSc.
Positive_regulation (induce) of Localization (clearance) of PrPSc
5) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777304 Disease Relevance 0.09 Pain Relevance 0

General Comments

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