INT69569

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2010
Negated 4
Speculated 5
Reported most in Body
Documents 175
Total Number 181
Disease Relevance 96.31
Pain Relevance 13.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
brain 15
neurons 14
plasma 10
skin 9
cerebral cortex 5
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 153 99.68 Very High Very High Very High
Inflammation 121 99.56 Very High Very High Very High
Thalamus 804 99.32 Very High Very High Very High
cerebral cortex 50 99.24 Very High Very High Very High
Central nervous system 210 99.20 Very High Very High Very High
addiction 47 99.12 Very High Very High Very High
anesthesia 279 98.58 Very High Very High Very High
fifth nerve 21 98.56 Very High Very High Very High
Eae 62 98.16 Very High Very High Very High
Substantia nigra 14 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Scrapie 3090 100.00 Very High Very High Very High
Disease 2837 100.00 Very High Very High Very High
Alzheimer's Dementia 291 100.00 Very High Very High Very High
Creutzfeldt Jakob Disease 2647 99.98 Very High Very High Very High
Prion Diseases 959 99.84 Very High Very High Very High
Stress Incontinence 875 99.84 Very High Very High Very High
Encephalitis 46 99.80 Very High Very High Very High
Stress 175 99.74 Very High Very High Very High
Neurodegenerative Disease 250 99.64 Very High Very High Very High
Death 528 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A slight but nonsignificant increase of PrPC mRNA levels was found in the contralateral hemisphere.
Positive_regulation (increase) of PrPC mRNA
1) Confidence 0.70 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.35 Pain Relevance 0.08
We found that the inhibitors caused accumulation of an unglycosylated, aggregated form of PrP exclusively in transfected N2a expressing PrP from the cytomegalovirus promoter.
Positive_regulation (accumulation) of PrP associated with cytomegalovirus infection
2) Confidence 0.70 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15632159 Disease Relevance 0.39 Pain Relevance 0.08
It this context, it is interesting to note that a recent study has demonstrated an upregulation of endogenous PrP in response to acute ischemic stroke in rats and also reported elevated PrP plasma levels in human stroke patients (Mitsios et al., 2007).
Positive_regulation (elevated) of PrP in plasma associated with stroke
3) Confidence 0.69 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.92 Pain Relevance 0.07
It this context, it is interesting to note that a recent study has demonstrated an upregulation of endogenous PrP in response to acute ischemic stroke in rats and also reported elevated PrP plasma levels in human stroke patients (Mitsios et al., 2007).
Positive_regulation (upregulation) of PrP in plasma associated with stroke
4) Confidence 0.69 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.92 Pain Relevance 0.08
Instead, we observed a slight increase in PrPSc as well as total PrP, likely due to the reduction in protein degradation in cells with fewer LEs/lysosomes (Figure 4A).
Positive_regulation (increase) of PrP
5) Confidence 0.69 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.13 Pain Relevance 0
Identification of an Intracellular Site of Prion Conversion

Prion diseases are fatal, neurodegenerative disorders in humans and animals and are characterized by the accumulation of an abnormally folded isoform of the cellular prion protein (PrPC), denoted PrPSc, which represents the major component of infectious scrapie prions.

Positive_regulation (accumulation) of PrPC associated with creutzfeldt jakob disease, scrapie and neurodegenerative disease
6) Confidence 0.69 Published 2009 Journal PLoS Pathogens Section Title Doc Link PMC2673690 Disease Relevance 0.70 Pain Relevance 0
Similarly, PrPSc levels were also increased in control cells (expressing GFP alone) treated with NH4Cl (Figure 6B right panels).
Positive_regulation (increased) of PrPSc
7) Confidence 0.69 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.06 Pain Relevance 0
We reasoned that if the reduction of PrPSc by Rab22a was due to increased lysosomal degradation, a block of the lysosomal function with NH4Cl should revert its effect and result in unchanged or increased PrPSc levels.
Positive_regulation (increased) of PrPSc
8) Confidence 0.69 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.08 Pain Relevance 0
Prion diseases are neurodegenerative disorders characterized by accumulation of an aberrantly folded isoform (PrP(Sc)) of the normal prion protein (PrP(C)).
Positive_regulation (accumulation) of PrP associated with creutzfeldt jakob disease and neurodegenerative disease
9) Confidence 0.64 Published 2007 Journal Neurobiol. Aging Section Abstract Doc Link 16621165 Disease Relevance 0.28 Pain Relevance 0.25
Prion diseases are neurodegenerative disorders characterized by accumulation of an aberrantly folded isoform (PrP(Sc)) of the normal prion protein (PrP(C)).
Positive_regulation (accumulation) of PrP associated with creutzfeldt jakob disease and neurodegenerative disease
10) Confidence 0.64 Published 2007 Journal Neurobiol. Aging Section Abstract Doc Link 16621165 Disease Relevance 0.28 Pain Relevance 0.24
Although PrPSc accumulation has been demonstrated to be the primary pathogenic event in prion disease, the exact molecular and cellular mechanisms of its formation and the ensuing neurodegeneration remain largely unknown.
Positive_regulation (accumulation) of PrPSc associated with creutzfeldt jakob disease
11) Confidence 0.64 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777304 Disease Relevance 0.80 Pain Relevance 0
Thus, whether and to what degree the skin plays a role in the spread of contagious scrapie in the field, and whether BSE-infected cattle, CWD-infected deer or vCJD-infected humans may also accumulate PrPSc in the skin, remains to be established in future studies.


Positive_regulation (accumulate) of PrPSc in skin associated with creutzfeldt jakob disease, chronic wasting disease and scrapie
12) Confidence 0.61 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1876502 Disease Relevance 1.25 Pain Relevance 0.03
Colby et al. reported that sPrPSc was generated in vitro during polymerization of recPrP into amyloid fibers.
Positive_regulation (generated) of sPrPSc associated with alzheimer's dementia
13) Confidence 0.61 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2950034 Disease Relevance 0.60 Pain Relevance 0.07
Initial PrP accumulation around neurons and in early plaques lacking amyloid fibrils was generally not associated with morphological changes either of the neuron or dendrite releasing the PrP or in the adjacent neuropil in which excess PrP accumulated.
Positive_regulation (accumulation) of PrP in plaques associated with alzheimer's dementia
14) Confidence 0.61 Published 1997 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 9160894 Disease Relevance 1.20 Pain Relevance 0
Previous in situ hybridization experiments have suggested that NR2A and NR2B but not NR1 mRNA may be upregulated in both young and adult PrP-null mice (Maglio et al., 2004, 2006), which is not supported by our semiquantitative PCR experiments.
Positive_regulation (upregulated) of PrP
15) Confidence 0.61 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.05 Pain Relevance 0.06
In many paradigms, expression of heterologous PrP molecules which differ from the endogenous PrP by as little as one amino acid can profoundly interfere with the overall accumulation of PrPSc [30], [31], suggesting that precise homotypic interactions between PrP molecules are important for PrPSc accumulation [31], [32].
Positive_regulation (accumulation) of PrPSc
16) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.63 Pain Relevance 0
In many paradigms, expression of heterologous PrP molecules which differ from the endogenous PrP by as little as one amino acid can profoundly interfere with the overall accumulation of PrPSc [30], [31], suggesting that precise homotypic interactions between PrP molecules are important for PrPSc accumulation [31], [32].
Positive_regulation (accumulation) of PrPSc
17) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.52 Pain Relevance 0
Indeed, when we blocked PrP exit from EEs the levels of PrPSc were drastically reduced and an accumulation of PrPC in EEs was observed (Figures 2A, 2C, 5A, 5B, S8B, S8C and S8D).
Positive_regulation (accumulation) of PrPC
18) Confidence 0.60 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.08 Pain Relevance 0
As expected from a block of lysosomal degradation we observed an increase in total cellular PrP levels in NH4Cl-treated cells (in both control cells transfected with GFP and in cells transfected with GFP-Rab22a) when compared to untreated cells (Figure 6B right panels).
Positive_regulation (increase) of PrP
19) Confidence 0.60 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.07 Pain Relevance 0
Identification of an Intracellular Site of Prion Conversion

Prion diseases are fatal, neurodegenerative disorders in humans and animals and are characterized by the accumulation of an abnormally folded isoform of the cellular prion protein (PrPC), denoted PrPSc, which represents the major component of infectious scrapie prions.

Positive_regulation (accumulation) of prion protein associated with creutzfeldt jakob disease, scrapie and neurodegenerative disease
20) Confidence 0.60 Published 2009 Journal PLoS Pathogens Section Title Doc Link PMC2673690 Disease Relevance 0.70 Pain Relevance 0

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