INT6957

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 38
Total Number 40
Disease Relevance 6.55
Pain Relevance 7.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OXTR) signal transducer activity (OXTR)
Anatomy Link Frequency
uterine 5
myometrium 3
plasma 3
uterus 3
organ systems 2
OXTR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 28 100.00 Very High Very High Very High
Endogenous opioid 11 100.00 Very High Very High Very High
addiction 4 99.92 Very High Very High Very High
Opioid 15 99.82 Very High Very High Very High
Dopamine 67 99.60 Very High Very High Very High
Kinase C 5 99.52 Very High Very High Very High
Dismenorea 41 99.36 Very High Very High Very High
narcan 35 99.28 Very High Very High Very High
Acupuncture 20 99.00 Very High Very High Very High
withdrawal 9 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dysmenorrhea 35 99.36 Very High Very High Very High
Hypoglycemia 6 99.20 Very High Very High Very High
Pre-term Labor 49 98.64 Very High Very High Very High
Pain 21 98.16 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 96.96 Very High Very High Very High
Reprotox - General 1 46 91.76 High High
Retained Placenta 4 91.00 High High
Premature Birth 324 89.20 High High
Post-partum Hemorrhage 5 85.88 High High
Hypertension 16 85.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: In comparison to the negative controls the immunohistochemical reactivity demonstrated increasing oxytocin receptor concentrations with maximum levels under 17-beta-estradiol and oxytocin stimulation in the uterine fundus (40% of positive stained cells, p<0.01).
Positive_regulation (increasing) of oxytocin in uterine
1) Confidence 0.70 Published 2003 Journal Arch. Gynecol. Obstet. Section Body Doc Link 14605818 Disease Relevance 0 Pain Relevance 0
These findings show that in man oxytocin requires an active opioid system in order to produce its inhibitory action on ACTH-cortisol secretion, suggesting that this effect of oxytocin could be mediated by an opioid pathway.
Positive_regulation (mediated) of oxytocin associated with opioid
2) Confidence 0.69 Published 1985 Journal Acta Endocrinol. Section Abstract Doc Link 2982243 Disease Relevance 0 Pain Relevance 0.67
The progress of labour is not related to an increase in oxytocin concentration, uterine contractions are not associated with changes in plasma oxytocin concentration and hypocontractile labour does not appear to be the result of a deficit of oxytocin.
Positive_regulation (increase) of oxytocin in plasma associated with dismenorea
3) Confidence 0.68 Published 1992 Journal Acta Endocrinol. Section Abstract Doc Link 1621487 Disease Relevance 0.10 Pain Relevance 0.10
The dramatic increase in human uterine oxytocin receptors at term makes the uterus responsive to very small amounts of oxytocin.
Positive_regulation (increase) of oxytocin in uterus
4) Confidence 0.61 Published 1989 Journal Am J Perinatol Section Abstract Doc Link 2540759 Disease Relevance 0 Pain Relevance 0.07
These results strongly suggest that oxytocin levels in human plasma and CSF are controlled by different mechanisms and that the increased oxytocin could have some specific central actions.
Positive_regulation (increased) of oxytocin in CSF
5) Confidence 0.55 Published 1985 Journal Endocrinol. Jpn. Section Abstract Doc Link 3833528 Disease Relevance 0.07 Pain Relevance 0.08
However, little is known about the mutual dependence of the oxytocin receptor, oxytocin and 17-beta-estradiol in the nonpregnant myometrium and about the distribution of the oxytocin receptor in the nonpregnant uterus.
Positive_regulation (dependence) of oxytocin in myometrium associated with addiction
6) Confidence 0.50 Published 2003 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 14605818 Disease Relevance 0.09 Pain Relevance 0.14
However, little is known about the mutual dependence of the oxytocin receptor, oxytocin and 17-beta-estradiol in the nonpregnant myometrium and about the distribution of the oxytocin receptor in the nonpregnant uterus.
Positive_regulation (dependence) of oxytocin in myometrium associated with addiction
7) Confidence 0.50 Published 2003 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 14605818 Disease Relevance 0.09 Pain Relevance 0.14
We perfused 10 uteri for 27 h under physiological conditions without 17-beta-estradiol (group A, n=5) or with high 17-beta-estradiol stimulation (group B, n=5) followed by oxytocin stimulation in both groups in the last 3 h of the experiment.
Positive_regulation (stimulation) of oxytocin
8) Confidence 0.50 Published 2003 Journal Arch. Gynecol. Obstet. Section Body Doc Link 14605818 Disease Relevance 0 Pain Relevance 0
Hence, an increased oxytocin secretion rate is not a necessary prerequisite for oxytocin-stimulated contractions during labor.
Positive_regulation (increased) of oxytocin
9) Confidence 0.50 Published 1989 Journal Am J Perinatol Section Abstract Doc Link 2540759 Disease Relevance 0 Pain Relevance 0.08
Presently, there is little evidence for an increased maternal secretion rate of oxytocin at the onset of labor, but during labor a progressive increase occurs, with a maximum at the expulsive phase.
Positive_regulation (increased) of oxytocin
10) Confidence 0.50 Published 1989 Journal Am J Perinatol Section Abstract Doc Link 2540759 Disease Relevance 0 Pain Relevance 0.05
The present study was carried out in an attempt to determine whether an opioid pathway mediates oxytocin action; therefore, we evaluated the effect of naloxone on the decrease of cortisol induced by oxytocin.
Spec (whether) Positive_regulation (mediates) of oxytocin associated with narcan and opioid
11) Confidence 0.50 Published 1985 Journal Acta Endocrinol. Section Abstract Doc Link 2982243 Disease Relevance 0 Pain Relevance 0.59
In an extracorporeal perfusion model of the swine uterus the effect of dynamic changes in uterine contractility and peristalsis in response to oxytocin and estrogen administration was observed.
Positive_regulation (response) of oxytocin in uterus
12) Confidence 0.47 Published 2006 Journal Eur. J. Med. Res. Section Abstract Doc Link 16720280 Disease Relevance 0.12 Pain Relevance 0.12
[The effect of oxytocin stimulation on PGE2, 6keto PGF1 alpha production in human myometrial monolayer culture].
Positive_regulation (stimulation) of oxytocin
13) Confidence 0.45 Published 1993 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Title Doc Link 8315315 Disease Relevance 0 Pain Relevance 0.06
The majority of patients do not demonstrate an increase in plasma oxytocin concentration during the second stage of labour; however, a minority produce a large surge immediately before delivery.
Positive_regulation (increase) of oxytocin in plasma
14) Confidence 0.45 Published 1992 Journal Acta Endocrinol. Section Abstract Doc Link 1621487 Disease Relevance 0.09 Pain Relevance 0.09
Protein kinase C causes a strong inhibitory feedback on the oxytocin pathway: protein kinase C activators abolish the response to oxytocin while inhibitors potentiate it.
Positive_regulation (response) of oxytocin associated with kinase c
15) Confidence 0.45 Published 1995 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 8713998 Disease Relevance 0.34 Pain Relevance 0.13
The biological role of oxytocin increase during sexual stimulation and arousal with a peak during orgasm for the mechanisms of reproduction may be to stimulate directed uterine transport mechanisms in the presence of estrogens.
Positive_regulation (increase) of oxytocin in uterine
16) Confidence 0.44 Published 2006 Journal Eur. J. Med. Res. Section Abstract Doc Link 16720280 Disease Relevance 0.16 Pain Relevance 0.16
Myometrium is stimulated by increased concentrations ofprostaglandins and oxytocin.
Positive_regulation (increased) of oxytocin in Myometrium
17) Confidence 0.44 Published 2001 Journal Coll Antropol Section Abstract Doc Link 11811300 Disease Relevance 0.48 Pain Relevance 0.08
The importance of oxytocin and vasopressin in mechanisms of preterm labor is confirmed by the therapeutic effect in the condition of the oxytocin and vasopressin V1a receptor blocking oxytocin analogue, atosiban.
Positive_regulation (importance) of oxytocin associated with pre-term labor
18) Confidence 0.41 Published 2002 Journal Prog. Brain Res. Section Abstract Doc Link 12436949 Disease Relevance 0.55 Pain Relevance 0.22
The duration and intensity of contractions, meconium-stained piglets and intrapartum deaths decreased as time at which oxytocin administered during labor was increased.
Positive_regulation (increased) of oxytocin in meconium
19) Confidence 0.40 Published 2007 Journal Biol. Res. Section Abstract Doc Link 17657355 Disease Relevance 0.14 Pain Relevance 0.14
In all cases more than 36 weeks gestation the index was positive for oxytocin (night-time levels were higher) and in all cases the index was negative for beta-endorphin (night-time levels were lower).
Positive_regulation (positive) of oxytocin
20) Confidence 0.40 Published 1996 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 8959083 Disease Relevance 0 Pain Relevance 0

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