INT69571

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1997
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 5.88
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
hindlimb 3
Notch 2
neocortex 2
brains 2
forelimb 1
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
Thalamus 58 99.68 Very High Very High Very High
Central nervous system 15 99.68 Very High Very High Very High
addiction 9 96.84 Very High Very High Very High
Hippocampus 16 80.92 Quite High
anesthesia 10 75.68 Quite High
medulla 4 57.60 Quite High
Peripheral nervous system 9 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Pyramidal cell 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Scrapie 287 100.00 Very High Very High Very High
Disease 107 100.00 Very High Very High Very High
Sprains And Strains 23 99.98 Very High Very High Very High
Infection 97 99.36 Very High Very High Very High
Cytomegalovirus Infection 1 97.76 Very High Very High Very High
Prion Diseases 34 97.72 Very High Very High Very High
Creutzfeldt Jakob Disease 161 95.64 Very High Very High Very High
Gliosis 5 88.60 High High
Stress Incontinence 70 82.72 Quite High
Alzheimer's Dementia 3 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that the inhibitors caused accumulation of an unglycosylated, aggregated form of PrP exclusively in transfected N2a expressing PrP from the cytomegalovirus promoter.
Positive_regulation (caused) of Positive_regulation (accumulation) of PrP associated with cytomegalovirus infection
1) Confidence 0.70 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15632159 Disease Relevance 0.39 Pain Relevance 0.08
In contrast to what we previously described for PrPSc, nuclear accumulation of 23-230 PrP does not require a functional microtubule network.
Neg (not) Positive_regulation (require) of Positive_regulation (accumulation) of PrP
2) Confidence 0.44 Published 2006 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 16806967 Disease Relevance 0.15 Pain Relevance 0.07
This information is a prerequisite to the second half of this review in which we present evidence that rPrPSc accumulation in synaptic regions links Notch-1 signaling with the dendritic degeneration.
Positive_regulation (links) of Positive_regulation (accumulation) of rPrPSc in Notch
3) Confidence 0.43 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC2825502 Disease Relevance 0.60 Pain Relevance 0
The earliest and highest accumulation of rPrPSc occurred in the thalamus in both models and it took approximately 4 weeks for transmission of rPrPSc from the thalamus to the neocortex in both models.
Positive_regulation (occurred) of Positive_regulation (accumulation) of rPrPSc in neocortex associated with thalamus
4) Confidence 0.43 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2825502 Disease Relevance 0.67 Pain Relevance 0.10
Infection of mice with the 87 V or ME7 scrapie strains results in distinctive and very different light microscopical patterns of vacuolation and disease specific PrP accumulation.
Positive_regulation (results) of Positive_regulation (accumulation) of PrP associated with scrapie, disease, sprains and strains and infection
5) Confidence 0.41 Published 1997 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 9160894 Disease Relevance 1.27 Pain Relevance 0
PrPSc accumulation in the brains of quinacrine-treated, RML-inoculated MDR0/0 mice
Positive_regulation (inoculated) of Positive_regulation (accumulation) of PrPSc in brains
6) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777304 Disease Relevance 0.59 Pain Relevance 0.24
In order to examine whether accumulation of PrPSc in the skin depends on the mode of infection and spreading pathways other than the nervous system, skin specimens from the forelimb and hindlimb of terminally ill hamsters challenged with 263K scrapie agent by different routes were analyzed using the same analytical approach as described above for the time-course study.
Spec (whether) Positive_regulation (depends) of Spec (whether) Positive_regulation (accumulation) of PrPSc in hindlimb associated with scrapie and infection
7) Confidence 0.38 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1876502 Disease Relevance 0.75 Pain Relevance 0.05
Accumulation of Pathological Prion Protein PrPSc in the Skin of Animals with Experimental and Natural Scrapie

Prion infectivity and its molecular marker, the pathological prion protein PrPSc, accumulate in the central nervous system and often also in lymphoid tissue of animals or humans affected by transmissible spongiform encephalopathies.

Positive_regulation (accumulate) of in central nervous system Positive_regulation (Accumulation) of PrPSc in Skin associated with prion diseases, scrapie and central nervous system
8) Confidence 0.38 Published 2007 Journal PLoS Pathogens Section Title Doc Link PMC1876502 Disease Relevance 0.70 Pain Relevance 0.09
In order to examine whether accumulation of PrPSc in the skin depends on the mode of infection and spreading pathways other than the nervous system, skin specimens from the forelimb and hindlimb of terminally ill hamsters challenged with 263K scrapie agent by different routes were analyzed using the same analytical approach as described above for the time-course study.
Spec (whether) Positive_regulation (depends) of in forelimb Spec (whether) Positive_regulation (accumulation) of PrPSc in hindlimb associated with scrapie and infection
9) Confidence 0.13 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1876502 Disease Relevance 0.75 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox