INT69572

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.81
First Reported 1997
Last Reported 2010
Negated 3
Speculated 5
Reported most in Body
Documents 96
Total Number 103
Disease Relevance 38.11
Pain Relevance 5.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
neuronal 6
neurons 5
brain 3
boutons 3
upper 3
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 88 99.68 Very High Very High Very High
Inflammation 64 99.56 Very High Very High Very High
Thalamus 388 98.84 Very High Very High Very High
fifth nerve 6 98.56 Very High Very High Very High
Glutamate 36 98.44 Very High Very High Very High
Hippocampus 147 98.40 Very High Very High Very High
pruritus 20 97.60 Very High Very High Very High
Pain 12 96.64 Very High Very High Very High
addiction 19 95.80 Very High Very High Very High
Central nervous system 74 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Scrapie 1660 100.00 Very High Very High Very High
Alzheimer's Dementia 140 99.98 Very High Very High Very High
Amyloid Plaque 33 99.96 Very High Very High Very High
Encephalitis 19 99.80 Very High Very High Very High
Encephalopathy 675 99.76 Very High Very High Very High
Neurodegenerative Disease 171 99.60 Very High Very High Very High
Staphylococcus Infection 9 99.56 Very High Very High Very High
Prion Diseases 385 99.52 Very High Very High Very High
Disease 1331 99.18 Very High Very High Very High
Infection 1125 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nuclear localization of this mutant form of PrP is independent of its predicted nuclear localization signals.
Localization (localization) of PrP
1) Confidence 0.81 Published 2006 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 16806967 Disease Relevance 0.17 Pain Relevance 0.08
Initial PrP accumulation around neurons and in early plaques lacking amyloid fibrils was generally not associated with morphological changes either of the neuron or dendrite releasing the PrP or in the adjacent neuropil in which excess PrP accumulated.
Localization (releasing) of PrP in plaques associated with alzheimer's dementia
2) Confidence 0.80 Published 1997 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 9160894 Disease Relevance 1.21 Pain Relevance 0
We conclude that pre-amyloid PrP release and accumulation is not invariably toxic, either to the neuron releasing PrP or to the neuropil into which it is released.
Localization (releasing) of PrP in neuron associated with alzheimer's dementia
3) Confidence 0.80 Published 1997 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 9160894 Disease Relevance 0.98 Pain Relevance 0.08
For NR2D and PrP colocalization, NR2D (1:200; Santa Cruz Biotechnology, Inc.) and mouse monoclonal anti-PrP (1:200; Chemicon) antibodies were used and conjugated to AlexaFluor488 IgG and AlexaFluor546 IgG, respectively.
Localization (colocalization) of PrP
4) Confidence 0.80 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.06 Pain Relevance 0.06
Instead, by quantitative fluorescence analysis we observed a preferential localization of PrPSc in the endosomal recycling compartment of all three cells lines tested (Figure 1 and Figure S2).
Localization (localization) of PrPSc
5) Confidence 0.79 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.20 Pain Relevance 0.03
Interestingly, we observed that Alix depletion did not affect the intracellular localization of PrPC and PrPSc, which were found to be enriched in the ERC similar to control cells (Figure 4B, compare colocalization with Tfn in control and treated cells for PrPC (?
Localization (localization) of PrPSc
6) Confidence 0.79 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.10 Pain Relevance 0
Less information is available about the intracellular localization of PrPSc.
Localization (localization) of PrPSc
7) Confidence 0.79 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.20 Pain Relevance 0
Interestingly, we observed that Alix depletion did not affect the intracellular localization of PrPC and PrPSc, which were found to be enriched in the ERC similar to control cells (Figure 4B, compare colocalization with Tfn in control and treated cells for PrPC (?
Localization (localization) of PrPC
8) Confidence 0.79 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.10 Pain Relevance 0
Other studies (36) have demonstrated that the octapeptide repeat region of PrPC is required for reactive oxygen species-mediated ?
Localization (region) of PrPC
9) Confidence 0.75 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.62 Pain Relevance 0.10
Animals inoculated with this PK-resistant PrP showed abnormalities after an average incubation period of 112.6 days and revealed spongiform degeneration, astroglyosis, and PrP accumulation.
Localization (accumulation) of PrP associated with congenital anomalies
10) Confidence 0.75 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2950034 Disease Relevance 0.49 Pain Relevance 0
PrPC has been localized to synaptic contacts, suggesting a possible role in synaptic physiology.
Localization (localized) of PrPC
11) Confidence 0.75 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.06 Pain Relevance 0.03
We utilized a quantitative MS technique, isotope-coded affinity tagging (ICAT), to determine the relative abundance of PrP and other proteins in the various samples, so to identify proteins that might exist in an equimolar complex with PrPC.
Spec (determine) Localization (abundance) of PrP
12) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.05 Pain Relevance 0
To differentiate PrPmyc transgenic littermates with Prnp+/o and Prnpo/o genotype the presence of the endogenous Prnp+ allele was tested by PCR analysis using primers Prnp intron 2 (5?
Localization (allele) of Prnp associated with targeted disruption
13) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.42 Pain Relevance 0
However, in contrast to earlier reports [11],[13],[17] we did not observe any localization of PrPSc in the Golgi compartment (Figure 1A lower panel) the majority of the intracellular protein being localized throughout the endocytic pathway.
Localization (localization) of PrPSc
14) Confidence 0.74 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
Instead, a significant amount of PrPSc was distributed in GFP-Rab22a-positive EEs, similar to what was observed for PrPC (Figure 6A, upper panels, arrowheads and Figure 5A).
Localization (distributed) of PrPSc in upper
15) Confidence 0.74 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.07 Pain Relevance 0
Interestingly, in two other infected neuronal cell lines, ScCAD and ScN2a, PrPC was almost exclusively localized at the cell surface (data not shown).
Localization (localized) of PrPC in neuronal
16) Confidence 0.74 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.09 Pain Relevance 0.11
40%) in EEs after the treatment (compare control cells with treated cells in Figure 2C and Figure S3C, and see quantification of EEA-1/PrP colocalization in Figure 2D).
Localization (colocalization) of PrP
17) Confidence 0.74 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
One of these phenotypes, named bovine “amyloidotic” spongiform encephalopathy (BASE), differs from classical BSE for the occurrence of a distinct type of the disease-associated prion protein (PrP), termed PrPSc, and the presence of PrP amyloid plaques.
Localization (presence) of PrP in plaques associated with creutzfeldt jakob disease, disease and amyloid plaque
18) Confidence 0.74 Published 2007 Journal PLoS Pathogens Section Abstract Doc Link PMC1817656 Disease Relevance 1.80 Pain Relevance 0
Electron microscopy has shown that PrPC is located ubiquitously throughout the plasma membrane, which includes synaptic boutons and postsynaptic membranes; PrPC was not found on synaptic vesicles [34].
Localization (located) of PrPC in synaptic vesicles
19) Confidence 0.73 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2825502 Disease Relevance 0.05 Pain Relevance 0.07
Multiple variations in a host animal's amino acid sequence of PrPSc, variations in the ?
Localization (sequence) of PrPSc
20) Confidence 0.73 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2825502 Disease Relevance 0.41 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox