INT69588

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Context Info
Confidence 0.13
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 0.42
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gars) ligase activity (Gars) cytoplasm (Gars)
Anatomy Link Frequency
dorsal horn 1
Gars (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 20 100.00 Very High Very High Very High
agonist 4 100.00 Very High Very High Very High
spinal dorsal horn 51 99.94 Very High Very High Very High
Endocannabinoid 2 97.28 Very High Very High Very High
IPN 6 92.88 High High
Pain 20 91.92 High High
Analgesic 4 91.80 High High
Spinal cord 37 91.32 High High
medulla 1 89.24 High High
interneuron 3 87.84 High High
Disease Link Frequency Relevance Heat
Nociception 12 99.40 Very High Very High Very High
Inflammatory Pain 6 92.88 High High
Pain 17 91.92 High High
Premenstrual Syndrome 18 28.84 Quite Low
Epilepsy 6 5.00 Very Low Very Low Very Low
Anxiety Disorder 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low
Affective Disorder 3 5.00 Very Low Very Low Very Low
Convulsion 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, the concentrations at which E2 exerted significant effects on GlyRs were much higher than its physiological level.
Regulation (effects) of GlyRs
1) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.04
In adult spinal dorsal horn (SDH), GlyRs are important in regulating nociception and motor function.
Regulation (important) of GlyRs in dorsal horn associated with nociception and spinal dorsal horn
2) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0.19 Pain Relevance 0.45
However, the estradiol effects on GlyRs remain unexplored.
Regulation (effects) of GlyRs
3) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0.14 Pain Relevance 0.32
The effects of picrotoxin on these two GlyRs were first analyzed by measuring the relative change in their total open probability (NP(o)) with picrotoxin concentration.
Regulation (effects) of GlyRs
4) Confidence 0.07 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9163366 Disease Relevance 0 Pain Relevance 0.04
The present study characterised the effects of cannabinoid agonists on alpha1, alpha1beta, alpha2 and alpha3 GlyRs recombinantly expressed in HEK293 cells with the aims of reconciling effects of cannabinoids on these receptor subtypes and to establish the potential of different GlyR isoforms as novel physiological or analgesic targets for cannabinoids.
Regulation (effects) of GlyRs associated with analgesic, cannabinoid and agonist
5) Confidence 0.03 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18755158 Disease Relevance 0.09 Pain Relevance 0.64
Our results also establish GlyRs as potential novel targets for endogenous and exogenous cannabinoids.
Regulation (targets) of GlyRs associated with cannabinoid
6) Confidence 0.03 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18755158 Disease Relevance 0 Pain Relevance 0.52

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