INT69588

Context Info Confidence 0.13 First Reported 1997 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 6 Disease Relevance 0.42 Pain Relevance 2.01

mitochondrion (Gars) ligase activity (Gars) cytoplasm (Gars)

Anatomy Link Frequency dorsal horn 1 Gars (Rattus norvegicus)

Pain Link Frequency Relevance Heat Cannabinoid 20 100.00 agonist 4 100.00 spinal dorsal horn 51 99.94 Endocannabinoid 2 97.28 IPN 6 92.88 Pain 20 91.92 Analgesic 4 91.80 Spinal cord 37 91.32 medulla 1 89.24 interneuron 3 87.84

Disease Link Frequency Relevance Heat Nociception 12 99.40 Inflammatory Pain 6 92.88 Pain 17 91.92 Premenstrual Syndrome 18 28.84 Epilepsy 6 5.00 Anxiety Disorder 6 5.00 Disease 6 5.00 Decapitation 3 5.00 Affective Disorder 3 5.00 Convulsion 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the present study, the concentrations at which E2 exerted significant effects on GlyRs were much higher than its physiological level.

Regulation (effects) of GlyRs

1) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.04

In adult spinal dorsal horn (SDH), GlyRs are important in regulating nociception and motor function.

Regulation (important) of GlyRs in dorsal horn associated with nociception and spinal dorsal horn

2) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0.19 Pain Relevance 0.45

However, the estradiol effects on GlyRs remain unexplored.

Regulation (effects) of GlyRs

3) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0.14 Pain Relevance 0.32

The effects of picrotoxin on these two GlyRs were first analyzed by measuring the relative change in their total open probability (NP(o)) with picrotoxin concentration.

Regulation (effects) of GlyRs

4) Confidence 0.07 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9163366 Disease Relevance 0 Pain Relevance 0.04

The present study characterised the effects of cannabinoid agonists on alpha1, alpha1beta, alpha2 and alpha3 GlyRs recombinantly expressed in HEK293 cells with the aims of reconciling effects of cannabinoids on these receptor subtypes and to establish the potential of different GlyR isoforms as novel physiological or analgesic targets for cannabinoids.

Regulation (effects) of GlyRs associated with analgesic, cannabinoid and agonist

5) Confidence 0.03 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18755158 Disease Relevance 0.09 Pain Relevance 0.64

Our results also establish GlyRs as potential novel targets for endogenous and exogenous cannabinoids.

Regulation (targets) of GlyRs associated with cannabinoid

6) Confidence 0.03 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18755158 Disease Relevance 0 Pain Relevance 0.52

General Comments

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