INT69588
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
In the present study, the concentrations at which E2 exerted significant effects on GlyRs were much higher than its physiological level. | |||||||||||||||
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In adult spinal dorsal horn (SDH), GlyRs are important in regulating nociception and motor function. | |||||||||||||||
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However, the estradiol effects on GlyRs remain unexplored. | |||||||||||||||
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The effects of picrotoxin on these two GlyRs were first analyzed by measuring the relative change in their total open probability (NP(o)) with picrotoxin concentration. | |||||||||||||||
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The present study characterised the effects of cannabinoid agonists on alpha1, alpha1beta, alpha2 and alpha3 GlyRs recombinantly expressed in HEK293 cells with the aims of reconciling effects of cannabinoids on these receptor subtypes and to establish the potential of different GlyR isoforms as novel physiological or analgesic targets for cannabinoids. | |||||||||||||||
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Our results also establish GlyRs as potential novel targets for endogenous and exogenous cannabinoids. | |||||||||||||||
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General Comments
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