INT69592

Context Info Confidence 0.70 First Reported 1997 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 27 Total Number 27 Disease Relevance 17.83 Pain Relevance 18.98

enzyme regulator activity (PSMD1) cytosol (PSMD1) nucleoplasm (PSMD1) small molecule metabolic process (PSMD1) cellular nitrogen compound metabolic process (PSMD1)

Anatomy Link Frequency cortex 3 digits 2 trunk 2 ICD 1 inner wall 1 PSMD1 (Homo sapiens)

Pain Link Frequency Relevance Heat primary somatosensory cortex 65 100.00 Somatosensory cortex 41 99.80 Pain 510 99.68 amygdala 34 99.66 allodynia 50 99.42 Anterior cingulate cortex 58 99.38 insula 64 99.36 Thalamus 26 98.84 reflex sympathetic dystrophy 15 98.00 methadone 13 97.20

Disease Link Frequency Relevance Heat Tics 102 99.96 Metastasis 15 99.88 Sprains And Strains 5 99.84 Pain 573 99.62 Neuropathic Pain 64 99.42 Amputation 16 99.42 Stomach Cancer 4 99.28 Gastritis 6 99.00 Pathologic Constriction 1 98.48 Ulcers 2 98.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The area of S1 activated during VS of the digits in a normal control subject was coextensive with the ventral S1 region abnormally activated during VS of the ectopic phantom representation in the two amputees, suggesting that the deafferented digit or hand/arm area had been activated by sensory input from the pectoral region.

Positive_regulation (activated) of S1 in digits associated with primary somatosensory cortex

1) Confidence 0.70 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9163390 Disease Relevance 0.34 Pain Relevance 0.62

The contralateral S1 cortex was activated during painful mechanical stimulation of the hand, whereas tooth pain lead to bilateral activation of S1.

Positive_regulation (activation) of S1 in cortex associated with pain

2) Confidence 0.70 Published 2005 Journal Pain Section Abstract Doc Link 16289801 Disease Relevance 0.63 Pain Relevance 0.96

The area of S1 activated during VS of the digits in a normal control subject was coextensive with the ventral S1 region abnormally activated during VS of the ectopic phantom representation in the two amputees, suggesting that the deafferented digit or hand/arm area had been activated by sensory input from the pectoral region.

Positive_regulation (activated) of S1 in digits associated with primary somatosensory cortex

3) Confidence 0.50 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9163390 Disease Relevance 0.34 Pain Relevance 0.62

Results indicate that the S1 is not only involved in the actual perception of pain and touch but also plays an important role in extracting somatic features from social interactions.

Positive_regulation (involved) of S1 associated with pain and primary somatosensory cortex

4) Confidence 0.50 Published 2007 Journal Cereb. Cortex Section Abstract Doc Link 17205974 Disease Relevance 0.50 Pain Relevance 0.88

[A case of gastric cancer with multiple bone metastasis that responded to S-1 with low-dose cis-platinum].

Positive_regulation (responded) of S-1 associated with metastasis and stomach cancer

5) Confidence 0.49 Published 2008 Journal Gan To Kagaku Ryoho Section Title Doc Link 18195541 Disease Relevance 0.80 Pain Relevance 0.11

Subgroup analysis using rating-weighted predictors revealed activation of the contralateral thalamus, anterior cingulate cortex, and amygdala and a bilateral activation of S1, S2, and insular cortex and prefrontal cortices in allodynia-experienced subjects.

Positive_regulation (activation) of S1 in insular cortex associated with allodynia, thalamus, amygdala and anterior cingulate cortex

6) Confidence 0.48 Published 2008 Journal J Pain Section Abstract Doc Link 18455481 Disease Relevance 1.23 Pain Relevance 1.54

VS of the pectoral region adjacent to the intact arm was associated with activation of the dorsal part of the contralateral primary somatosensory cortex (S1) in a position consistent with the S1 trunk area.

Positive_regulation (activation) of S1 in trunk associated with primary somatosensory cortex

7) Confidence 0.41 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9163390 Disease Relevance 0.41 Pain Relevance 0.53

In contrast, VS of the pectoral region ipsilateral to the amputation with RS was associated with activation of the contralateral S1 that extended from the level of the trunk representation ventrally over distances of 20 and 12 mm, respectively, in the two subjects.

Positive_regulation (activation) of S1 in trunk associated with primary somatosensory cortex and amputation

8) Confidence 0.41 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9163390 Disease Relevance 0.38 Pain Relevance 0.54

The contralateral S1 cortex was activated during painful mechanical stimulation of the hand, whereas tooth pain lead to bilateral activation of S1.

Positive_regulation (activated) of S1 in cortex associated with pain

9) Confidence 0.41 Published 2005 Journal Pain Section Abstract Doc Link 16289801 Disease Relevance 0.56 Pain Relevance 0.88

The results of direct stimulation of the S1 nerve root and recording from the soleus are shown in Table 2.

Positive_regulation (stimulation) of S1 in soleus

10) Confidence 0.38 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1177957 Disease Relevance 0 Pain Relevance 0

For both evoked and spontaneous tics, activation in S1 (PoCG, Brodmann Area 2 or 3) was observed contralateral to the pain in the area corresponding to the somatotopic representation of the origin of the painful tics (i.e., face – actual pain was just lateral to the upper right lip).

Positive_regulation (activation) of S1 in lateral associated with pain and tics

11) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2217520 Disease Relevance 1.65 Pain Relevance 0.95

[A case of ascending colon cancer with enlarged metastatic lymph nodes around superior mesenteric arterial root that responded dramatically to S-1 and CPT-11 combination chemotherapy].

Positive_regulation (responded) of S-1 in superior associated with colon cancer

12) Confidence 0.32 Published 2007 Journal Gan To Kagaku Ryoho Section Title Doc Link 17496457 Disease Relevance 0.58 Pain Relevance 0.10

It potentially could be attributed to activation in S1 and S2 and recorded together, since both are activated by noxious stimuli [13].

Positive_regulation (activation) of S1

13) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778627 Disease Relevance 0.22 Pain Relevance 0.38

In prior studies using fMRI we have reported specific and somatotopic activation in the S1 region following similar painful thermal stimuli to the three divisions of the face [12], [13] that included the one used here, i.e., the ophthalmic division of the trigeminal nerve also designated as V1 or the first division of the nerve.

Positive_regulation (activation) of S1 in nerve associated with pain and fifth nerve

14) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778627 Disease Relevance 0.18 Pain Relevance 0.43

In contrast, allodynia-inexperienced subjects only activated contralateral S1 and bilateral S2.

Positive_regulation (activated) of S1 associated with allodynia

15) Confidence 0.28 Published 2008 Journal J Pain Section Abstract Doc Link 18455481 Disease Relevance 1.20 Pain Relevance 1.56

The group analysis of all subjects revealed that tactile stimulation activated contralateral somatosensory cortices (S1 [primary] and S2 [secondary]), but the imagination of allodynia led to an additional activation of anterior cingulate cortex and bilateral activation of S2, insular cortex, and prefrontal cortices.

Positive_regulation (activated) of S1 in cingulate cortex associated with allodynia and anterior cingulate cortex

16) Confidence 0.28 Published 2008 Journal J Pain Section Abstract Doc Link 18455481 Disease Relevance 1.14 Pain Relevance 1.40

Studies of sensorimotor cortical activation following innocuous stimulation have reported both unilateral [7] as well as bilateral S1 activation [8], [9].

Positive_regulation (activation) of S1

17) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778627 Disease Relevance 0 Pain Relevance 0.19

For simplicity, this activation is referred to in the manuscript as S1 activation.

Positive_regulation (activation) of S1

18) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778627 Disease Relevance 0 Pain Relevance 0.04

Maihöfner et al. [26] observed activations in the S1 and S2 cortex, insula, PFC, and in the ACC during pin-prick stimulation of CRPS patients who experience hyperalgesia.

Positive_regulation (activations) of S1 in insula associated with somatosensory cortex, hyperalgesia, primary somatosensory cortex, reflex sympathetic dystrophy, insula and anterior cingulate cortex

19) Confidence 0.22 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 1.53 Pain Relevance 1.95

The patient was informed that data concerning the case would be submitted for publication, and he consented.Fig. 7Sagittal MR images obtained 1 month after the surgery, showing two confluent (L5 and S1) rootlets (arrows) Discussion

Positive_regulation (showing) of S1

20) Confidence 0.19 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2948130 Disease Relevance 0.30 Pain Relevance 0.33

General Comments

This test has worked.