INT69593

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 4.06
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (PSMD1) cytosol (PSMD1) nucleoplasm (PSMD1)
small molecule metabolic process (PSMD1) cellular nitrogen compound metabolic process (PSMD1)
Anatomy Link Frequency
gray matter 1
liver 1
facet 1
PCC 1
posterior 1
PSMD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
primary somatosensory cortex 29 100.00 Very High Very High Very High
Deafferentation 3 100.00 Very High Very High Very High
medulla 5 99.64 Very High Very High Very High
Anterior cingulate cortex 11 99.04 Very High Very High Very High
Pain 187 98.72 Very High Very High Very High
analgesia 35 96.96 Very High Very High Very High
Thalamus 6 96.08 Very High Very High Very High
abdominal pain 1 95.16 Very High Very High Very High
Somatosensory cortex 3 94.80 High High
Lasting pain 8 82.56 Quite High
Disease Link Frequency Relevance Heat
Gastrointestinal Neoplasms 2 99.60 Very High Very High Very High
Stomach Cancer 17 99.20 Very High Very High Very High
Diarrhoea 2 98.80 Very High Very High Very High
Pain 191 98.72 Very High Very High Very High
Peritonitis 4 98.72 Very High Very High Very High
Hepatotoxicity 1 98.34 Very High Very High Very High
Cardiovascular Disease 70 98.16 Very High Very High Very High
Abdominal Pain 1 95.16 Very High Very High Very High
Cancer 194 92.16 High High
Emergencies 1 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ipsilateral hand muscle contraction was associated with a decrease of source activity in S1 and with subsequent increases in S2(L) and the PCC.
Negative_regulation (decrease) of S1 in PCC associated with primary somatosensory cortex
1) Confidence 0.57 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15998566 Disease Relevance 0.19 Pain Relevance 0.70
[A case of perforated gastric cancer in which resection for elimination was possible S-1/CDDP combined chemotherapy for peritonitis carcinomatosa].
Spec (possible) Negative_regulation (possible) of S-1 associated with peritonitis and stomach cancer
2) Confidence 0.41 Published 2009 Journal Gan To Kagaku Ryoho Section Title Doc Link 19151576 Disease Relevance 0.90 Pain Relevance 0.10
The findings are consistent with the hypothesis that deafferentation of an area of S1 may result in activation of previously dormant inputs from body surfaces represented in immediately adjacent parts of S1.
Negative_regulation (deafferentation) of S1 in body associated with primary somatosensory cortex and deafferentation
3) Confidence 0.37 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9163390 Disease Relevance 0.05 Pain Relevance 0.59
Results suggest early suppression of source activity in S1 during ipsilateral hand muscle contractions and in bilateral S2 during contralateral hand muscle contractions.
Negative_regulation (suppression) of S1 in hand muscle associated with primary somatosensory cortex
4) Confidence 0.36 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15998566 Disease Relevance 0.10 Pain Relevance 0.59
Schmidt-Wilke et al. [102] also found gray matter loss in the DLPFC of CLBP patients as well as decreased volumes in S1 and the brainstem.
Negative_regulation (decreased) of S1 in gray matter associated with medulla and primary somatosensory cortex
5) Confidence 0.33 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2266926 Disease Relevance 0.08 Pain Relevance 0.37
BOLD activity increases and decreases (Table S1) significantly correlated with pain relief during the partner trials were identified, masking out any regions also associated with pain relief in the distraction task.
Negative_regulation (decreases) of S1 associated with pain
6) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954158 Disease Relevance 0.63 Pain Relevance 0.86
In addition to STS, evoked fields sensitive to predictability of S1 dynamics also showed sources localized to posterior fusiform gyrus.
Negative_regulation (predictability) of S1 in posterior
7) Confidence 0.24 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2820709 Disease Relevance 0 Pain Relevance 0.03
Based on these results as well as the FLAGS data, it is unlikely that S1 will be developed in upper gastrointestinal cancers in the United States.


Negative_regulation (developed) of S1 in upper associated with gastrointestinal neoplasms
8) Confidence 0.21 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2856525 Disease Relevance 0.67 Pain Relevance 0
Despite slight disc space narrowing at L5-S1, there was no clear abnormalityFig. 2Myelograms showing incomplete block at L5 pedicular level, especially on the right side (arrows)Fig. 3CT performed following myelography, showing absence of the right L5-S1 facet jointFig. 43D-CT showing complete absence of the S1 superior articular process (circle)Fig. 5a MR sagittal images showing disc herniation at L5-S1 intervertebral disc level. b Axial MR T2-weighted images showing the herniated nucleus pulposus (HNP, left panel), which migrated cranially (b, right panel)
Negative_regulation (absence) of S1 in facet
9) Confidence 0.16 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2948130 Disease Relevance 0 Pain Relevance 0.06
Since drug-induced liver dysfunction (grade 3) and diarrhea (grade 2) developed after completion of the 2nd cycle, the S-1 dose was reduced to 40 mg/m2 after their improvement, and 6 cycles of administration were performed in total (total dose: S-1: 7,560 mg as tegafur, CPT-11: 480 mg).
Negative_regulation (reduced) of S-1 in liver associated with diarrhoea and hepatotoxicity
10) Confidence 0.09 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1395313 Disease Relevance 0.93 Pain Relevance 0.04
Fig. 2Jablonski representation of FRET As a fluorophore absorbs light it is excited from the ground state (S0) to a higher vibrational level (S1?
Negative_regulation (level) of S1
11) Confidence 0.08 Published 2009 Journal Target Oncol Section Body Doc Link PMC2778706 Disease Relevance 0 Pain Relevance 0
The list of genes and the number of variants successfully genotyped for each gene are presented in Table 3, and detailed information on all variants is presented in Table S1.
Negative_regulation (presented) of S1
12) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.50 Pain Relevance 0

General Comments

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