INT69652

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Context Info
Confidence 0.61
First Reported 1997
Last Reported 2010
Negated 3
Speculated 6
Reported most in Body
Documents 26
Total Number 32
Disease Relevance 17.17
Pain Relevance 15.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (P2rx3)
Anatomy Link Frequency
neurons 6
lateral 2
ureter 1
bladder 1
nociceptors 1
P2rx3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 80 99.84 Very High Very High Very High
nMDA receptor 15 99.80 Very High Very High Very High
Pain 171 99.78 Very High Very High Very High
qutenza 108 99.78 Very High Very High Very High
opioid receptor 1 99.68 Very High Very High Very High
Snapping jaw 9 99.42 Very High Very High Very High
Neuropathic pain 62 98.96 Very High Very High Very High
dorsal root ganglion 334 98.68 Very High Very High Very High
trigeminal ganglion 151 98.16 Very High Very High Very High
Root ganglion neuron 6 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 79 99.70 Very High Very High Very High
Temporomandibular Joint Syndrome 9 99.42 Very High Very High Very High
Neuropathic Pain 133 98.96 Very High Very High Very High
Ganglion Cysts 539 98.68 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

17 97.94 Very High Very High Very High
Nociception 156 97.16 Very High Very High Very High
INFLAMMATION 55 96.92 Very High Very High Very High
Pain 189 95.88 Very High Very High Very High
Reprotox - General 1 4 95.84 Very High Very High Very High
Headache 14 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we have examined the effect of nerve injury on adrenergic regulation of P2X3 and TRPV1 receptors by administering alphabetaMeATP and capsaicin, alone and in combination with NA, into the lateral and medial hindpaw in the spared nerve injury (SNI) model; this allows for an exploration of the role of injured and uninjured afferents in their effects on nociceptive signaling using a behavioral model.
Spec (examined) Regulation (regulation) of P2X3 in medial associated with nociception, nervous system injury, qutenza and noradrenaline
1) Confidence 0.61 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18722504 Disease Relevance 0.61 Pain Relevance 0.51
Adrenergic regulation of P2X3 and TRPV1 receptors: differential effects of spared nerve injury.
Regulation (regulation) of P2X3 in nerve associated with nervous system injury and qutenza
2) Confidence 0.61 Published 2008 Journal Neurosci. Lett. Section Title Doc Link 18722504 Disease Relevance 0.64 Pain Relevance 0.83
These results demonstrate: (a) an enhanced adrenergic regulation of P2X3 receptor activity at lateral sites following SNI where signaling afferents are directly influenced by injured neurons; (b) differential effects on adrenergic regulation of TRPV1 receptors under the same conditions; (c) lack of such changes when agents are administered into medial sites following SNI.
Regulation (regulation) of P2X3 in lateral associated with nervous system injury
3) Confidence 0.61 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18722504 Disease Relevance 0.91 Pain Relevance 0.72
Antisense oligonucleotides have been used to down-regulate the P2X3 receptor, and in models of neuropathic (partial sciatic nerve ligation) and inflammatory (complete Freund's adjuvant pain, inhibition of the development of mechanical hyperalgesia as well as significant reversal of established hyperalgesia, were observed within 2 days of treatment [99-101].
Regulation (regulate) of P2X3 in sciatic nerve associated with pain, hyperalgesia, inflammation, neuropathic pain and sciatic nerve
4) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2789721 Disease Relevance 0.82 Pain Relevance 0.97
However, whether PAR2 activation has a direct impact on P2X3 currents is still not clear.
Regulation (impact) of P2X3
5) Confidence 0.43 Published 2010 Journal Neuroreport Section Abstract Doc Link 20118742 Disease Relevance 0.42 Pain Relevance 0.33
Transient changes in P2X3 but not TRPV1 mRNA expression in rat after prenatal exposure to glucocorticoids.
Regulation (changes) of P2X3
6) Confidence 0.38 Published 2008 Journal Auton Neurosci Section Title Doc Link 18541457 Disease Relevance 0.09 Pain Relevance 0.33
Phospholipid modulation of P2X3 receptors does not involve direct binding
Regulation (modulation) of P2X3
7) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0.05 Pain Relevance 0.03
Here, we show that the P2X3 receptor is another target of PGE2.
Regulation (target) of P2X3
8) Confidence 0.32 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.77 Pain Relevance 0.35
Dialysis with PIP2 analog into the recording pipette did not affect P2X3 currents under basal condition, indicating saturation by endogenous PIP2 in DRG neurons in primary culture.
Neg (not) Regulation (affect) of P2X3 in neurons associated with dorsal root ganglion
9) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0.38 Pain Relevance 0.27
NGF-induced modulation of P2X3 receptor function
Regulation (modulation) of P2X3
10) Confidence 0.27 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.42 Pain Relevance 0.19
Stretch receptors had currents that differed from those of P2X3 channels, and had no P2X3 immunoreactivity.
Neg (no) Regulation (immunoreactivity) of P2X3
11) Confidence 0.27 Published 1997 Journal Nature Section Abstract Doc Link 9168113 Disease Relevance 0.58 Pain Relevance 0.53
In addition, roles for the ligand-gated P2X3 and NMDA receptors, as well as pacemaker HCN channels have also been invoked in the pathogenesis of neuropathic pain.
Regulation (roles) of P2X3 associated with nmda receptor and neuropathic pain
12) Confidence 0.24 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469043 Disease Relevance 0.58 Pain Relevance 0.76
Increasing the concentration of the P2X3 GST fusion proteins from 1 ?
Regulation (concentration) of P2X3
13) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0.07 Pain Relevance 0.04
Antiserum against the P2X3-receptor subtype showed P2X3- receptor immunoreactivity in axon-like structures of the cervix, in small and medium-sized neurons in the L6/S1 DRG, and in lamina II of the L6/S1 spinal cord segments.
Regulation (immunoreactivity) of P2X3 in neurons associated with dorsal root ganglion and spinal cord
14) Confidence 0.22 Published 2005 Journal Cell Tissue Res. Section Abstract Doc Link 15902498 Disease Relevance 0.73 Pain Relevance 0.58
In this study, we have examined the effect of nerve injury on adrenergic regulation of P2X3 and TRPV1 receptors by administering alphabetaMeATP and capsaicin, alone and in combination with NA, into the lateral and medial hindpaw in the spared nerve injury (SNI) model; this allows for an exploration of the role of injured and uninjured afferents in their effects on nociceptive signaling using a behavioral model.
Spec (examined) Regulation (regulation) of P2X3 in lateral associated with nociception, nervous system injury, qutenza and noradrenaline
15) Confidence 0.21 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18722504 Disease Relevance 0.61 Pain Relevance 0.51
To test if P2X3 modulation involved direct binding to phosphoinositides, GST-fusion proteins coding for the C-terminal region of P2X3 homologous to the identified phosphoinositide binding region in other P2X receptors were generated.
Regulation (modulation) of P2X3
16) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0 Pain Relevance 0
Activation of EP signaling plays a role in neuronal sensitization mediating modulation of the transient receptor potential vanilloid subfamily 1 (TRPV1) receptor and P2X3 receptor [9,10].
Regulation (modulation) of P2X3 in neuronal
17) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949724 Disease Relevance 1.18 Pain Relevance 0.78
-meATP activates only P2X1 and P2X3 receptors [7] and the antagonist, A-317491, which acts specifically on P2X3 receptors [23], abolished both current responses (Fig. 1A).
Regulation (91, ) of P2X3 associated with antagonist
18) Confidence 0.19 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.30 Pain Relevance 0.26
In support of this proposal, these authors have shown P2X3 receptor immunoreactivity in axons in the cervix, in small and medium sized neurons in L6/S1 DRG and in lamina II of the L6/S1 spinal cord segments and increases in P2X3 receptor expression between pregnancy day 10 and parturition (day 22/23) in the rat cervix, although not in DRG or spinal cord.


Regulation (immunoreactivity) of P2X3 in cervix associated with spinal cord
19) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2789721 Disease Relevance 0.79 Pain Relevance 0.51
Chronic application of 5-HT to TG neurons in culture was followed by a large upregulation of TRPV1 receptor function without affecting P2X3 receptors.
Neg (without) Regulation (affecting) of P2X3 in neurons associated with trigeminal ganglion
20) Confidence 0.16 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.78 Pain Relevance 0.64

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