INT69665

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Context Info
Confidence 0.35
First Reported 1997
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.40
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc) plasma membrane (Oprd1) cytoplasm (Oprd1)
signal transducer activity (Oprd1)
Oprd1 (Rattus norvegicus)
Pnoc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 34 100.00 Very High Very High Very High
opioid receptor 11 100.00 Very High Very High Very High
Kappa opioid receptor 1 100.00 Very High Very High Very High
Opioid 3 99.52 Very High Very High Very High
Dynorphin 2 90.64 High High
Pain 3 88.44 High High
substantia gelatinosa 4 85.92 High High
Endogenous opioid 1 82.24 Quite High
Spinal cord 2 80.88 Quite High
Hippocampus 2 78.32 Quite High
Disease Link Frequency Relevance Heat
Nociception 2 94.88 High High
Pain 1 88.44 High High
Urological Neuroanatomy 2 71.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opioid receptor like 1 (ORL1) receptor is a novel member of the opioid receptor family, which was not bound by any of the typical opioid receptor ligands but bound by the recently discovered nociceptin (also termed orphanin FQ) with high affinity.
opioid receptor Binding (bound) of nociceptin associated with orphanin and opioid receptor
1) Confidence 0.35 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10963896 Disease Relevance 0.07 Pain Relevance 0.40
Opioid receptor like 1 (ORL1) receptor is a novel member of the opioid receptor family, which was not bound by any of the typical opioid receptor ligands but bound by the recently discovered nociceptin (also termed orphanin FQ) with high affinity.
Opioid receptor Binding (bound) of nociceptin associated with orphanin and opioid receptor
2) Confidence 0.24 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10963896 Disease Relevance 0.07 Pain Relevance 0.40
Nociceptin (NOC), also known as orphanin FQ, is a newly discovered endogenous ligand for the opioid receptor-like1 (ORL1) receptor.
opioid receptor Binding (ligand) of Nociceptin associated with orphanin and opioid receptor
3) Confidence 0.10 Published 2001 Journal Neuroscience Section Abstract Doc Link 11734364 Disease Relevance 0.09 Pain Relevance 0.60
The nociceptin pharmacophore site for opioid receptor binding derived from the NMR structure and bioactivity relationships.
opioid receptor Binding (binding) of nociceptin associated with orphanin and opioid receptor
4) Confidence 0.01 Published 2005 Journal J. Biol. Chem. Section Title Doc Link 15596448 Disease Relevance 0.09 Pain Relevance 0.44
Nociceptin, a novel heptadecapeptide, interacts with ORL1 a G protein-coupled receptor whose sequence is closely related to that of the kappa opioid receptor but has no opioid activity.
opioid receptor Binding (interacts) of Nociceptin associated with orphanin, kappa opioid receptor and opioid
5) Confidence 0.01 Published 1997 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9168905 Disease Relevance 0.07 Pain Relevance 0.66

General Comments

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