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Context Info
Confidence 0.45
First Reported 1997
Last Reported 1998
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.06
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc) plasma membrane (OPRL1) signal transducer activity (OPRL1)
OPRL1 (Homo sapiens)
Pnoc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 9 100.00 Very High Very High Very High
Kappa opioid receptor 5 100.00 Very High Very High Very High
Dynorphin 5 99.80 Very High Very High Very High
Opioid 5 95.52 Very High Very High Very High
opioid receptor 4 93.48 High High
opiate 1 81.16 Quite High
Enkephalin 3 78.44 Quite High
Endogenous opioid 1 74.24 Quite High
Disease Link Frequency Relevance Heat
Nociception 1 61.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nociceptin, a novel heptadecapeptide, interacts with ORL1 a G protein-coupled receptor whose sequence is closely related to that of the kappa opioid receptor but has no opioid activity.
ORL1 Binding (interacts) of Nociceptin associated with orphanin, kappa opioid receptor and opioid
1) Confidence 0.45 Published 1997 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9168905 Disease Relevance 0.06 Pain Relevance 0.61
Different domains of the ORL1 and kappa-opioid receptors are involved in recognition of nociceptin and dynorphin A.
ORL1 Binding (recognition) of nociceptin associated with dynorphin, orphanin and kappa opioid receptor
2) Confidence 0.06 Published 1998 Journal FEBS Lett. Section Title Doc Link 9607332 Disease Relevance 0 Pain Relevance 1.06

General Comments

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