INT6967

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1992
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 28
Total Number 32
Disease Relevance 3.37
Pain Relevance 4.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNMA1) transmembrane transport (KCNMA1)
Anatomy Link Frequency
myometrium 10
blood 1
uterus 1
pore 1
vestibule 1
KCNMA1 (Homo sapiens)
KCNMA1 - D387N (1)
Pain Link Frequency Relevance Heat
potassium channel 239 100.00 Very High Very High Very High
sodium channel 39 100.00 Very High Very High Very High
bradykinin 12 100.00 Very High Very High Very High
lidocaine 7 100.00 Very High Very High Very High
tetrodotoxin 268 99.42 Very High Very High Very High
Nav1.2 3 99.16 Very High Very High Very High
addiction 59 93.84 High High
Neuronal excitability 5 90.64 High High
dorsal root ganglion 62 89.76 High High
Mechanotransduction 5 86.44 High High
Disease Link Frequency Relevance Heat
Cancer 40 99.40 Very High Very High Very High
Disease 26 98.76 Very High Very High Very High
Breast Cancer 10 97.94 Very High Very High Very High
Pressure And Volume Under Development 2 97.68 Very High Very High Very High
Hereditary Angioedema 1 92.76 High High
Ganglion Cysts 66 89.76 High High
Apoptosis 27 88.56 High High
Metastasis 3 87.76 High High
Hypoxia 1 85.52 High High
Pre-term Labor 44 85.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, alteration of KCNMA1 function has been associated with several complex human disorders including cancer.
Regulation (alteration) of KCNMA1 associated with cancer
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.99 Pain Relevance 0
Further direct evidence for the role of alternate splicing of the maxi-K transcript in altering maxi-K protein function in myometrium is provided by the finding of up-regulation of maxi-K splice variants known to alter channel current through alterations in calcium and voltage sensitivity in pregnant mouse myometrium [19].
Regulation (altering) of maxi-K protein in myometrium
2) Confidence 0.54 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
Further evidence of the role of alternate splicing of the maxi-K transcript in altering maxi-K protein function in myometrium is provided by the finding of up-regulation of maxi-K splice variants known to alter channel current through alterations in calcium and voltage sensitivity in pregnant mouse myometrium [19].
Regulation (altering) of maxi-K protein in myometrium
3) Confidence 0.54 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0.04
There is a substantial body of evidence indicating that alternate splicing of the maxi-K transcript plays a major role in regulating potassium channel conductance [7,15].
Regulation (regulating) of channel in body associated with potassium channel
4) Confidence 0.47 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0.05
Further evidence of the role of alternate splicing of the maxi-K transcript in altering maxi-K protein function in myometrium is provided by the finding of up-regulation of maxi-K splice variants known to alter channel current through alterations in calcium and voltage sensitivity in pregnant mouse myometrium [19].
Regulation (alter) of channel in myometrium
5) Confidence 0.47 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0.04
Further direct evidence for the role of alternate splicing of the maxi-K transcript in altering maxi-K protein function in myometrium is provided by the finding of up-regulation of maxi-K splice variants known to alter channel current through alterations in calcium and voltage sensitivity in pregnant mouse myometrium [19].
Regulation (regulation) of maxi-K in myometrium
6) Confidence 0.47 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
Further direct evidence for the role of alternate splicing of the maxi-K transcript in altering maxi-K protein function in myometrium is provided by the finding of up-regulation of maxi-K splice variants known to alter channel current through alterations in calcium and voltage sensitivity in pregnant mouse myometrium [19].
Regulation (alter) of channel in myometrium
7) Confidence 0.47 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
Further evidence of the role of alternate splicing of the maxi-K transcript in altering maxi-K protein function in myometrium is provided by the finding of up-regulation of maxi-K splice variants known to alter channel current through alterations in calcium and voltage sensitivity in pregnant mouse myometrium [19].
Regulation (regulation) of maxi-K in myometrium
8) Confidence 0.47 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0.04
-subunit attachment and modulation of the calcium bowl, and their input to regulation of Maxi-K channels during human pregnancy and labour.
Regulation (regulation) of Maxi-K
9) Confidence 0.34 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
5 dilutions (5 fold dilutions) were set up for beta actin control and KCNMA1 target in separate duplicate wells.
Regulation (target) of KCNMA1
10) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0 Pain Relevance 0
AKAP6, located on the ER/SR, acts as an adapter molecule in co-localization of the PKA, which also phosphorylates and regulates the activity of KCNMA1 [44], [45].
Regulation (regulates) of KCNMA1
11) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.18 Pain Relevance 0
Previous studies provide evidence that alternate splicing effects calcium and voltage sensitivity of the maxi-K channel and thus channel function in myometrium [16], surface expression [17], and sensitivity to protein phosphorylation of the maxi-K channel [18].
Regulation (sensitivity) of maxi-K channel in myometrium
12) Confidence 0.21 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
While it is entirely likely that the time needed to see a fall in protein following changes in gene expression may not be provided for in laboring tissues, it is also possible that we do not detect labor-associated regulation of channel function such that continued presence of the protein is not inconsistent with labor.
Regulation (regulation) of channel
13) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0 Pain Relevance 0.07
Secondly, it is possible that it is the influence of the BK channel on the membrane potential that is critical, as it is in vascular tissue (Ledoux et al., 2006).
Spec (possible) Regulation (influence) of BK channel associated with potassium channel
14) Confidence 0.05 Published 2010 Journal Journal of Cellular Physiology Section Body Doc Link PMC2883078 Disease Relevance 0.09 Pain Relevance 0.22
Thus, the mechanisms that interfere with BK liberation or degradation would lead to blood pressure dysfunction.
Regulation (interfere) of BK in blood associated with bradykinin
15) Confidence 0.05 Published 2009 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 19689262 Disease Relevance 0.59 Pain Relevance 0.58
Potassium channel internalization (a state of the channel not reflected by gene or protein expression), has been shown to be affected by post-translational modifications which can be differentially regulated depending on metabolic states [43]–[45].
Neg (not) Regulation (reflected) of channel associated with potassium channel
16) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0 Pain Relevance 0.13
Because GsMTx-4 affects all stretch-activated channels and thus in myometrium blocks both TREK-1 and TRAAK, we further tested the hypothesis that a TREK-1 more specific stretch-activated potassium channel inhibitor would diminish the ability of the myometrium to relax.
Regulation (affects) of stretch-activated in myometrium associated with potassium channel
17) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0 Pain Relevance 0.05
To verify the significance of stretch-activated channels to the physiological function of the myometrium, we explored the effects of inhibiting stretch-activated channels.
Regulation (effects) of stretch-activated in myometrium
18) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.06 Pain Relevance 0
This dysregulation may be the result of changes in channel expression levels, post-translational modulation and/or variant channel expression and dysfunctional channel assembly.
Regulation (changes) of channel
19) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.08 Pain Relevance 0.12
We were therefore interested in elucidating the role and possible regulation of the stretch-activated channels, TREK and TRAAK.
Spec (possible) Regulation (regulation) of stretch-activated
20) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.09 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox