INT69675

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Context Info
Confidence 0.32
First Reported 1997
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.69
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rel) cytoplasm (Rel)
Anatomy Link Frequency
neuronal 1
neurons 1
Rel (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 8 97.44 Very High Very High Very High
Inflammation 16 97.04 Very High Very High Very High
Nerve growth factor 8 93.96 High High
Inflammatory response 2 92.28 High High
Hyperalgesia 1 89.92 High High
Spinal cord 6 83.92 Quite High
Analgesic 5 82.04 Quite High
Enkephalin 2 76.28 Quite High
Opioid 2 75.00 Quite High
Pain 5 74.64 Quite High
Disease Link Frequency Relevance Heat
Necrosis 1 98.32 Very High Very High Very High
Cancer 2 97.96 Very High Very High Very High
INFLAMMATION 20 97.04 Very High Very High Very High
Frailty 12 93.20 High High
Hyperalgesia 1 89.92 High High
Nociception 1 89.24 High High
Pain 7 74.64 Quite High
Nervous System Injury 2 73.76 Quite High
Inflammatory Pain 1 52.16 Quite High
Infection 76 51.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, DADLE at 1 pM selectively increases c-Jun and c-Fos, but not c-Rel.
Positive_regulation (increases) of c-Rel
1) Confidence 0.32 Published 2005 Journal Synapse Section Abstract Doc Link 15945062 Disease Relevance 0 Pain Relevance 0.65
The increase in NF-kappa B/Rel binding within 24 hr following sRBC sensitization is consistent with the positive influence TGF-beta 1 exerts on Th1 cytokines such as IL-2 and IFN-gamma.
Positive_regulation (increase) of Rel associated with cytokine
2) Confidence 0.20 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.12
B family member c-Rel, which is not activated by acetylation, is expressed in cultured DRG neurons (Fig 2B).
Neg (not) Positive_regulation (activated) of c-Rel in neurons
3) Confidence 0.13 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0.35 Pain Relevance 0.59
, and Toll-like receptors lead to the release of p50:cRel and p50:relA dimers through the classic pathway.
Positive_regulation (lead) of cRel
4) Confidence 0.12 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.34 Pain Relevance 0.10
There were decreases in neuronal c-Rel levels and inverse increases in p65 and p50 levels.
Positive_regulation (increases) of c-Rel in neuronal
5) Confidence 0.02 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 17918744 Disease Relevance 1.00 Pain Relevance 0.25

General Comments

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