INT69676

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Context Info
Confidence 0.47
First Reported 1997
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.16
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rel) cytoplasm (Rel)
Anatomy Link Frequency
B cells 1
Rel (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 156 99.44 Very High Very High Very High
cytokine 129 97.32 Very High Very High Very High
Inflammation 14 87.44 High High
Paracetamol 3 81.56 Quite High
chemokine 22 66.32 Quite High
opiate 36 5.00 Very Low Very Low Very Low
Central nervous system 14 5.00 Very Low Very Low Very Low
opioid receptor 12 5.00 Very Low Very Low Very Low
Opioid 8 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 87.44 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 64 50.00 Quite Low
General Immunology 2 12.52 Low Low
Dementia 4 5.00 Very Low Very Low Very Low
Drug Dependence 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Viral Meningitis 4 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Opportunistic Infections 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely the decrease in NF-kappa B/Rel binding at the later time period during the AFC response (Days 2-4) coincides with the inhibitory effects TGF-beta 1 exerted on IgM production by B cells.
Rel Binding (binding) of in B cells
1) Confidence 0.47 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.11
The increase in NF-kappa B/Rel binding within 24 hr following sRBC sensitization is consistent with the positive influence TGF-beta 1 exerts on Th1 cytokines such as IL-2 and IFN-gamma.
Rel Binding (binding) of associated with cytokine
2) Confidence 0.47 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.12
Concomitantly, TGF-beta 1 induced a rapid increase in NF-kappa B/Rel trans-acting factor binding within the first 24 hr post-sRBC sensitization of splenocytes.
Rel Binding (binding) of
3) Confidence 0.36 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.12
B (p50/p65), p50 homodimer, and c-Rel DNA binding activity compared to cells that lacked the inhibitor.
c-Rel Binding (activity) of
4) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.44
Unlike the results with combined treatment, morphine treatment alone suppressed c-Rel DNA binding activity to levels below the limit of detection at 4 h, but not at 24 h (0.63±0.01) (Table 1).
c-Rel Neg (not) Binding (activity) of associated with morphine
5) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.16 Pain Relevance 0.59

General Comments

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