INT69677

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Context Info
Confidence 0.41
First Reported 1997
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.17
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rel) cytoplasm (Rel)
Anatomy Link Frequency
B cells 2
Rel (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 78 99.66 Very High Very High Very High
cytokine 64 98.24 Very High Very High Very High
Inflammation 7 87.88 High High
chemokine 11 66.32 Quite High
Paracetamol 1 64.12 Quite High
opiate 18 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
opioid receptor 6 5.00 Very Low Very Low Very Low
Opioid 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 11 87.88 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 32 50.00 Quite Low
General Immunology 1 12.96 Low Low
Dementia 2 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Viral Meningitis 2 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Opportunistic Infections 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely the decrease in NF-kappa B/Rel binding at the later time period during the AFC response (Days 2-4) coincides with the inhibitory effects TGF-beta 1 exerted on IgM production by B cells.
Negative_regulation (decrease) of Rel Binding (binding) of in B cells
1) Confidence 0.41 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.11
Unlike the results with combined treatment, morphine treatment alone suppressed c-Rel DNA binding activity to levels below the limit of detection at 4 h, but not at 24 h (0.63±0.01) (Table 1).
Neg (not) Negative_regulation (suppressed) of c-Rel Neg (not) Binding (activity) of associated with morphine
2) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.17 Pain Relevance 0.60

General Comments

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