INT69680

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.04
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Tgfb1) cytoplasm (Tgfb1) cell proliferation (Tgfb1)
extracellular space (Tgfb1) extracellular region (Tgfb1) cell death (Tgfb1)
Anatomy Link Frequency
liver 2
epithelium 2
Tgfb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 1 98.20 Very High Very High Very High
fibrosis 3 94.32 High High
Chronic pancreatitis 1 88.08 High High
anesthesia 1 50.04 Quite High
cytokine 1 27.84 Quite Low
Disease Link Frequency Relevance Heat
Injury 5 100.00 Very High Very High Very High
Fibrosis 4 97.00 Very High Very High Very High
Targeted Disruption 3 91.80 High High
Pancreatitis 1 88.08 High High
Primary Sclerosing Cholangitis 3 76.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar increases in TGF-beta 1 transcripts scripts in the liver were also induced by an acute hepatotoxic dose (600 mg/kg) of acetaminophen.
Positive_regulation (induced) of Positive_regulation (increases) of TGF-beta 1 in liver associated with paracetamol
1) Confidence 0.67 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.10
At this time, mRNA levels of TGF-beta1 were increased.
Positive_regulation (increased) of Positive_regulation (levels) of TGF-beta1
2) Confidence 0.41 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11123210 Disease Relevance 0.86 Pain Relevance 0.20
Additionally, cell proliferation increased in epithelium infected with Smad7 adv consistent with suppression of injury-induced upregulation of TGFbeta1 in epithelium.
Positive_regulation (injury-induced) of Positive_regulation (upregulation) of TGFbeta1 in epithelium associated with injury
3) Confidence 0.14 Published 2004 Journal Lab. Invest. Section Abstract Doc Link 15258599 Disease Relevance 0.17 Pain Relevance 0.05

General Comments

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