INT69681

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Context Info
Confidence 0.51
First Reported 1997
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 42
Total Number 44
Disease Relevance 22.28
Pain Relevance 4.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Tgfb1) cytoplasm (Tgfb1) cell proliferation (Tgfb1)
extracellular space (Tgfb1) extracellular region (Tgfb1) cell death (Tgfb1)
Anatomy Link Frequency
neurons 2
synovial fluid 1
lymphocytes 1
B cells 1
spleen 1
Tgfb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 80 100.00 Very High Very High Very High
antagonist 12 100.00 Very High Very High Very High
Myofascial pain syndrome 2 98.16 Very High Very High Very High
fibrosis 58 97.76 Very High Very High Very High
Angina 6 97.08 Very High Very High Very High
chemokine 28 96.24 Very High Very High Very High
Neurotransmitter 44 95.60 Very High Very High Very High
Enkephalin 2 95.44 Very High Very High Very High
gABA 99 94.88 High High
Dopamine 3 93.56 High High
Disease Link Frequency Relevance Heat
Hypoxia 770 100.00 Very High Very High Very High
Parkinson's Disease 5 100.00 Very High Very High Very High
Keloid Scars 55 99.88 Very High Very High Very High
Hypersensitivity 47 99.74 Very High Very High Very High
Glioma 10 99.48 Very High Very High Very High
Volume Depletion And Dehydration 2 99.48 Very High Very High Very High
Apoptosis 313 99.08 Very High Very High Very High
Metastasis 1060 98.96 Very High Very High Very High
Death 168 98.72 Very High Very High Very High
Ocular Injury 58 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aquaporin-1 and Na/H exchanger-3 deficiency enhances TGF suppression of TGF probably by volume depletion-mediated TGF sensitization.
Negative_regulation (suppression) of TGF associated with volume depletion and dehydration
1) Confidence 0.51 Published 1999 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 10589702 Disease Relevance 0.66 Pain Relevance 0.15
Conversely the decrease in NF-kappa B/Rel binding at the later time period during the AFC response (Days 2-4) coincides with the inhibitory effects TGF-beta 1 exerted on IgM production by B cells.
Negative_regulation (effects) of TGF-beta 1 in B cells
2) Confidence 0.41 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.11
Conversely, NF-kappa B/Rel binding activity was inhibited on Days 2 through 4 in sRBC-sensitized splenocytes in the presence of TGF-beta 1.
Negative_regulation (presence) of TGF-beta 1
3) Confidence 0.41 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.12
Aquaporin-1 and Na/H exchanger-3 deficiency enhances TGF suppression of TGF probably by volume depletion-mediated TGF sensitization.
Negative_regulation (suppression) of TGF associated with volume depletion and dehydration
4) Confidence 0.38 Published 1999 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 10589702 Disease Relevance 0.66 Pain Relevance 0.15
It is likely that downregulation of TGF-?
Negative_regulation (downregulation) of TGF
5) Confidence 0.26 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.54 Pain Relevance 0.03
A penetrating ocular injury 24 h and 48 h following AC injection led to a marked DTH response, a downregulation of TGF-?
Negative_regulation (downregulation) of TGF associated with hypersensitivity and ocular injury
6) Confidence 0.19 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.79 Pain Relevance 0.05
In the absence of MPTP, TGFbeta1 greatly decreased the number of dopaminergic neurons in the ventral mesencephalon of fully mature mice.
Negative_regulation (absence) of TGFbeta1 in mesencephalon associated with parkinson's disease
7) Confidence 0.19 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 12932441 Disease Relevance 0.72 Pain Relevance 0.22
Serum TNF-alpha level increased but the TGFbeta1 level decreased in CP/CPPS patients.
Negative_regulation (decreased) of TGFbeta1
8) Confidence 0.17 Published 2010 Journal Urology Section Body Doc Link 19800664 Disease Relevance 0.07 Pain Relevance 0
We previously postulated that these regressive changes in the OPC/CFU-f compartment occurred in old animals because of a reduction in the amount and/or activity of TGF-beta1, an autocrine growth factor important in the promotion of OPC/CFU-f proliferation and differentiation.
Negative_regulation (reduction) of TGF-beta1
9) Confidence 0.17 Published 1998 Journal J. Cell. Biochem. Section Abstract Doc Link 9712146 Disease Relevance 0.77 Pain Relevance 0.07
Previous studies using mouse models have shown that blockade of TGF-?
Negative_regulation (blockade) of TGF
10) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.01 Pain Relevance 0.05
Thus, combination therapy with inhibitors of hypoxia and TGF-?
Negative_regulation (inhibitors) of TGF associated with hypoxia
11) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.32 Pain Relevance 0
After 4 weeks of treatment, bortezomib decreased TGF-beta1 levels in marrow fluids and impaired marrow and spleen fibrosis development.
Negative_regulation (decreased) of TGF-beta1 in spleen associated with fibrosis
12) Confidence 0.09 Published 2007 Journal Blood Section Abstract Doc Link 17374740 Disease Relevance 1.00 Pain Relevance 0.23
In summary, both inhibitory and excitatory contribution to the network activity within the preBötC was strongly affected after the loss of TGF-?
Negative_regulation (loss) of TGF
13) Confidence 0.08 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.16
As both inhibitory and excitatory central synaptic transmission was depressed, TGF-?
Negative_regulation (depressed) of TGF
14) Confidence 0.08 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.05
To determine whether the loss of TGF-?
Spec (whether) Negative_regulation (loss) of TGF
15) Confidence 0.08 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.11
Our data demonstrate that the loss of TGF-?
Negative_regulation (loss) of TGF
16) Confidence 0.08 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.10
To study whether the loss of TGF-?
Spec (whether) Negative_regulation (loss) of TGF
17) Confidence 0.08 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0.21 Pain Relevance 0
We show for the first time that both spontaneous and miniature IPSCs and EPSCs were significantly depressed in TGF-?
Negative_regulation (depressed) of TGF
18) Confidence 0.08 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0.07 Pain Relevance 0.14
Moreover, the analysis of miniature events and hypertonic sucrose stimulation pointed to a presynaptically localized defect in TGF-?
Negative_regulation (defect) of TGF
19) Confidence 0.08 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.05
Blockade of TGF-?
Negative_regulation (Blockade) of TGF
20) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.98 Pain Relevance 0

General Comments

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