INT69683

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 1997
Negated 1
Speculated 0
Reported most in Title
Documents 1
Total Number 7
Disease Relevance 0
Pain Relevance 0.53

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enzyme binding (Tgfb1) cytoplasm (Tgfb1) cell proliferation (Tgfb1)
extracellular space (Tgfb1) extracellular region (Tgfb1) cell death (Tgfb1)
Anatomy Link Frequency
liver 12
spleen 2
Tgfb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 7 99.80 Very High Very High Very High
cytokine 7 38.32 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of liver-associated transforming growth factor beta 1 (TGF-beta 1) mRNA expression by carbon tetrachloride leads to the inhibition of T helper 2 cell-associated lymphokines.
Positive_regulation (Induction) of Transcription (expression) of transforming growth factor beta 1 in liver
1) Confidence 0.67 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.07
Acute treatment of B6C3F1 mice with a hepatotoxic dose (500 mg/kg) of carbon tetrachloride (CCl4) produced a marked but transient increase in transforming growth factor beta 1 (TGF-beta 1) mRNA expression in the liver within 24 hr.
Positive_regulation (increase) of Transcription (expression) of TGF-beta 1 in liver
2) Confidence 0.58 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.07
Induction of liver-associated transforming growth factor beta 1 (TGF-beta 1) mRNA expression by carbon tetrachloride leads to the inhibition of T helper 2 cell-associated lymphokines.
Positive_regulation (liver-associated) of Transcription (expression) of transforming growth factor beta 1 in liver
3) Confidence 0.48 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.07
Induction of liver-associated transforming growth factor beta 1 (TGF-beta 1) mRNA expression by carbon tetrachloride leads to the inhibition of T helper 2 cell-associated lymphokines.
Positive_regulation (Induction) of Transcription (expression) of TGF-beta 1 in liver
4) Confidence 0.48 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.07
Acute treatment of B6C3F1 mice with a hepatotoxic dose (500 mg/kg) of carbon tetrachloride (CCl4) produced a marked but transient increase in transforming growth factor beta 1 (TGF-beta 1) mRNA expression in the liver within 24 hr.
Positive_regulation (increase) of Transcription (expression) of transforming growth factor beta 1 in liver
5) Confidence 0.48 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.07
Induction of liver-associated transforming growth factor beta 1 (TGF-beta 1) mRNA expression by carbon tetrachloride leads to the inhibition of T helper 2 cell-associated lymphokines.
Positive_regulation (liver-associated) of Transcription (expression) of TGF-beta 1 in liver
6) Confidence 0.48 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.07
No increase in TGF-beta 1 mRNA expression was detected in the spleen following treatment with either agent.
Neg (No) Positive_regulation (increase) of Transcription (expression) of TGF-beta 1 in spleen
7) Confidence 0.45 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.10

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