INT6969

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Context Info
Confidence 0.42
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 6.36
Pain Relevance 12.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (St8sia1) Golgi apparatus (St8sia1) lipid metabolic process (St8sia1)
Anatomy Link Frequency
plaque 1
foot 1
cerebellum 1
St8sia1 (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 71 100.00 Very High Very High Very High
antinociception 34 100.00 Very High Very High Very High
narcan 8 99.78 Very High Very High Very High
noradrenaline 4 99.16 Very High Very High Very High
tolerance 9 98.90 Very High Very High Very High
agonist 9 98.72 Very High Very High Very High
Pain 33 98.16 Very High Very High Very High
antagonist 10 98.10 Very High Very High Very High
Clonidine 10 97.92 Very High Very High Very High
Morphine 8 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 54 99.56 Very High Very High Very High
Shock 9 99.52 Very High Very High Very High
Pain 20 98.16 Very High Very High Very High
Cognitive Disorder 7 98.04 Very High Very High Very High
Amyloid Plaque 8 97.24 Very High Very High Very High
Targeted Disruption 8 96.16 Very High Very High Very High
Apoptosis 5 89.92 High High
Pheochromocytoma 1 89.32 High High
Adhesions 2 87.48 High High
Vascular Disease 1 83.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To clarify the function of b- and c-series gangliosides in pain sensation in vivo, we generated mice in whom the gene for the alpha-2,8-sialyltransferase (GD3 synthase), which is responsible for the generation of all b-series gangliosides as well as c-series gangliosides, was disrupted.
Negative_regulation (disrupted) of GD3 synthase associated with pain
1) Confidence 0.42 Published 2005 Journal Pain Section Abstract Doc Link 16150545 Disease Relevance 0.58 Pain Relevance 0.37
Moreover, it was hard to develop tolerance even by daily exposure to stress for 6 days, although SIA for 9 days decreased compared with those for 0 and 6 days.
Negative_regulation (decreased) of SIA associated with stress, antinociception and tolerance
2) Confidence 0.38 Published 2000 Journal Pharmacology Section Abstract Doc Link 10940783 Disease Relevance 0.58 Pain Relevance 1.09
A 3 min room temperature swim increased reaction times on the hot-plate and this naloxone-sensitive SIA was reduced significantly by prazosin (1-2 mg kg-1), idazoxan (0.5-1 mg kg-1) and yohimbine (0.5-1 mg kg-1) but enhanced by clonidine (0.5 mg kg-1) and noradrenaline (NA) (10 micrograms i.c.v.).
Negative_regulation (reduced) of SIA associated with antinociception, noradrenaline, narcan and clonidine
3) Confidence 0.38 Published 1990 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1982301 Disease Relevance 0.36 Pain Relevance 1.26
Levels of noradrenaline in the brain (minus the cerebellum) were decreased after the room temperature swim SIA.
Negative_regulation (decreased) of SIA in cerebellum associated with antinociception and noradrenaline
4) Confidence 0.38 Published 1990 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1982301 Disease Relevance 0.35 Pain Relevance 1.23
At the peak of SIA, incorporation of 3H-leucine was not changed in FS-SIA, but significantly inhibited in IW-SIA, and these effects were not modified by the pretreatment with CYH.
Negative_regulation (inhibited) of IW-SIA associated with shock and analgesia
5) Confidence 0.20 Published 1985 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3999472 Disease Relevance 0.58 Pain Relevance 1.74
Subanalgesic dose, 0.01 to 0.25 mg/kg, of clonidine (CLO), an alpha 2-adrenoceptor agonist, potentiated forced swimming (SW) stress induced analgesia (SIA) and suppressed psychological (PSY)-SIA in a dose dependent manner but did not affect foot-shock (FS)-SIA.
Negative_regulation (suppressed) of SIA in foot associated with stress, shock, agonist, analgesia and clonidine
6) Confidence 0.20 Published 1991 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 1667019 Disease Relevance 0.75 Pain Relevance 1.42
Thus inhibition of GD3-synthase can be a novel therapeutic target to combat the cognitive deficits, amyloid plaque formation and neurodegeneration seen in AD.
Negative_regulation (inhibition) of GD3-synthase in plaque associated with cognitive disorder and amyloid plaque
7) Confidence 0.15 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2948441 Disease Relevance 0.58 Pain Relevance 0
Muscimol, a GABAA receptor agonist, at doses of 0.25 to 1.0 mg/kg, affected each SIA differently, suppressed PSY-SIA at 0.25 mg/kg but tended to potentiate it at 1.0 mg/kg, potentiated SW-SIA dose-dependently and did not affect FS-SIA at the doses employed.
Negative_regulation (suppressed) of SIA associated with agonist and analgesia
8) Confidence 0.07 Published 1992 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1336079 Disease Relevance 0.16 Pain Relevance 1.29
Both bicuculline, a GABAA receptor antagonist, 0.5 to 2.0 mg/kg, and picrotoxin, a Cl- channel blocker, 0.25 to 1.0 mg/kg, dose-dependently suppressed PSY- and FS-SIA.
Negative_regulation (suppressed) of SIA associated with antagonist and analgesia
9) Confidence 0.05 Published 1992 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1336079 Disease Relevance 0.15 Pain Relevance 1.59
and b-series gangliosides (GQ1b, GT1b, GD3 and GD1b) and GD1a have higher affinities for A?
Negative_regulation (gangliosides) of GD3
10) Confidence 0.05 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2838405 Disease Relevance 0.25 Pain Relevance 0
Our results demonstrated that mice lacking NTS2 exhibit significantly reduced SIA following cold-water swim stress.
Negative_regulation (reduced) of SIA associated with stress and analgesia
11) Confidence 0.04 Published 2010 Journal Neuroscience Section Abstract Doc Link 20035838 Disease Relevance 1.19 Pain Relevance 1.52
Especially, NT-deficient mice were shown to exhibit reduced SIA following water avoidance or restraint stress.
Negative_regulation (reduced) of SIA associated with stress and analgesia
12) Confidence 0.03 Published 2010 Journal Neuroscience Section Abstract Doc Link 20035838 Disease Relevance 0.82 Pain Relevance 1.45

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